2-MeO-Ketamine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
Aliases: Dinoket, Methoxyketamine, 2-meo-2-deschloroketamine
Summary
Very limited formal pharmacology or toxicology data exists. Potency appears roughly comparable to racemic ketamine but with a steeper dose-response curve and slightly shorter duration. Users report it is smoother intranasally and considerably more active orally than ketamine, suggesting higher oral bioavailability.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 15-60mg | 60-130mg | 130-200mg | 200mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 4-10 min | 10-19 min | 19-60 min | 30-60 min | 1-2 hrs |
| Oral | 19-40 min | 19-40 min | 19-60 min | 30-60 min | 1-2 hrs |
| Intramuscular | 1-4 min | 4-10 min | 19-60 min | 30-60 min | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth and motor impairment with moderate mania
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Dissociatives develop tolerance rapidly with repeated use; spacing multi‑week breaks helps. Cross‑tolerance is expected across NMDA‑antagonists. Data for 2‑MeO‑K specifically are anecdotal; figures above extrapolate from ketamine user data.
Cross-Tolerances
Effects
- Pain relief
- Physical euphoria
- Stimulation
- Analgesia
- Nausea
- Numbness
- Loss of balance
- Increased heart rate
- Physical disconnection
- Sedation
- Euphoria
- Cognitive euphoria
- Motor control loss
- Thought disorganization
- Depersonalization
- Derealization
- Memory suppression
- Amnesia
- Physical autonomy
- Time distortion
- Increased music appreciation
- Tactile enhancement
- Tactile suppression
- Spatial disorientation
- Double vision
- Cognitive dysphoria
- Disinhibition
- Visual disconnection
- Internal hallucination
- Auditory distortion
Combinations
Cross-Check 2-MeO-Ketamine with another substanceBluelight Reference Guide
The Big & Dandy Methoxyketamine Thread
Note that the correct full name is 2-MeO-Deschloroketamine Also called 2-MeO-Ketamine I have heared that the ketamine derivate 2-MeO-Ketamine (i.e. ketamine with the 2-chlorine group replaced by a 2-MeO-group, or more precisely, according to IUPAC, 2-(2-methoxyphenyl)-2-(methylamino)cyclohexanone) may have interesting...
Read full thread on Bluelight →Helpful Links
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