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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-MeO-Ketamine Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 4 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical

    Aliases: Dinoket, Methoxyketamine, 2-meo-2-deschloroketamine

    Dissociative Research-chemical

    Summary dose.wiki TripSit

    Very limited formal pharmacology or toxicology data exists. Potency appears roughly comparable to racemic ketamine but with a steeper dose-response curve and slightly shorter duration. Users report it is smoother intranasally and considerably more active orally than ketamine, suggesting higher oral bioavailability.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 15-60mg 60-130mg 130-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Insufflated 4-10 min 10-19 min 19-60 min 30-60 min 2-4 hrs 1-2 hrs
    Oral 19-40 min 19-40 min 19-60 min 30-60 min 2-4 hrs 1-2 hrs
    Intramuscular 1-4 min 4-10 min 19-60 min 30-60 min 2-4 hrs 1-2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 4.9
    Moderate+ 5/10

    Strong dissociative depth and motor impairment with moderate mania

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection visual disconnection physical autonomy spatial disorientation +2 more
    ⚠ Mania / Compulsion ×1
    6
    disinhibition stimulation euphoria
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Based on reports from:
    Bluelight Big & Dandy Thread
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-MeO-Ketamine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2-MeO-Ketamine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2-MeO-Ketamine
    Unit
    mg
    Description 
    2-MeO-Ketamine
Source: SubstanceSearch (substancesearch.com)

Insufflated dose (mg): threshold 5-15 · light 15-60 · common 60-130 · strong 130-200 · heavy 200+
Oral dose (mg): threshold 20-30
Intramuscular dose (mg): threshold 10

Insufflated duration: onset 4-10m · come-up 10-19m · peak 0.32-1h · offset 0.5-1h · total 1-2h · after-effects 2-4h
Oral duration: onset 19-40m · come-up 19-40m · peak 0.32-1h · offset 0.5-1h · total 1-2h · after-effects 2-4h
Intramuscular duration: onset 1-4m · come-up 4-10m · peak 0.32-1h · offset 0.5-1h · total 1-2h · after-effects 2-4h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 95 mg (Insufflated).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~30d

    Dissociatives develop tolerance rapidly with repeated use; spacing multi‑week breaks helps. Cross‑tolerance is expected across NMDA‑antagonists. Data for 2‑MeO‑K specifically are anecdotal; figures above extrapolate from ketamine user data.

    Cross-Tolerances

    Ketamine
    70%
    DXM
    50%
    MXE
    60%
    Other NMDA‑antagonist dissociatives
    50%

    Effects dose.wiki

    Positive
    • Pain relief
    • Physical euphoria
    • Stimulation
    • Analgesia
    Negative
    • Nausea
    • Numbness
    • Loss of balance
    • Increased heart rate
    Neutral
    • Physical disconnection
    • Sedation
    Positive
    • Euphoria
    • Cognitive euphoria
    Negative
    • Motor control loss
    • Thought disorganization
    • Depersonalization
    • Derealization
    • Memory suppression
    • Amnesia
    Neutral
    • Physical autonomy
    • Time distortion
    Positive
    • Increased music appreciation
    • Tactile enhancement
    Negative
    • Tactile suppression
    • Spatial disorientation
    • Double vision
    • Cognitive dysphoria
    • Disinhibition
    Neutral
    • Visual disconnection
    • Internal hallucination
    • Auditory distortion

    Combinations TripSit

    Cross-Check 2-MeO-Ketamine with another substance

    Bluelight Reference Guide Bluelight

    The Big & Dandy Methoxyketamine Thread

    Note that the correct full name is 2-MeO-Deschloroketamine Also called 2-MeO-Ketamine I have heared that the ketamine derivate 2-MeO-Ketamine (i.e. ketamine with the 2-chlorine group replaced by a 2-MeO-group, or more precisely, according to IUPAC, 2-(2-methoxyphenyl)-2-(methylamino)cyclohexanone) may have interesting...

    Read full thread on Bluelight →
    2-MeO-Ketamine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 TripSit 📖 Bluelight 📖 PsychonautWiki