2-MeO-Ketamine
Aliases: Dinoket, Methoxyketamine, 2-meo-2-deschloroketamine
Categories
Summary
Very limited formal pharmacology or toxicology data exists. Potency appears roughly comparable to racemic ketamine but with a steeper dose-response curve and slightly shorter duration. Users report it is smoother intranasally and considerably more active orally than ketamine, suggesting higher oral bioavailability. High doses can produce full anesthesia and complete dissociation (hole experience). Harm reduction: always confirm identity with reagent tests .
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 15-60mg | 60-130mg | 130-200mg | 200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Insufflated | 4-10 min | 10-19 min | 19-60 min | 30-60 min | 2.0-4.0 hrs | 1.0-2.0 hrs |
| Oral | 19-40 min | 19-40 min | 19-60 min | 30-60 min | 2.0-4.0 hrs | 1.0-2.0 hrs |
| Intramuscular | 1-4 min | 4-10 min | 19-60 min | 30-60 min | 2.0-4.0 hrs | 1.0-2.0 hrs |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Cross-tolerance
Effects
Positive
- Pain relief
- Physical euphoria
- Stimulation
- Analgesia
Negative
- Nausea
- Numbness
- Loss of balance
- Increased heart rate
- Physical disconnection
- Sedation
Positive
- Euphoria
- Cognitive euphoria
Negative
- Motor control loss
- Thought disorganization
- Depersonalization
- Derealization
- Memory suppression
- Amnesia
- Physical autonomy
- Time distortion
Positive
- Increased music appreciation
- Tactile enhancement
Negative
- Tactile suppression
- Spatial disorientation
- Double vision
- Cognitive dysphoria
- Disinhibition
- Visual disconnection
- Internal hallucination
- Auditory distortion