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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-MeO-Ketamine

    Aliases: Dinoket, Methoxyketamine, 2-meo-2-deschloroketamine

    Dissociative Research-chemical

    Summary TheDrug.Wiki TripSit

    Very limited formal pharmacology or toxicology data exists. Potency appears roughly comparable to racemic ketamine but with a steeper dose-response curve and slightly shorter duration. Users report it is smoother intranasally and considerably more active orally than ketamine, suggesting higher oral bioavailability.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 15-60mg 60-130mg 130-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Insufflated 4-10 min 10-19 min 19-60 min 30-60 min 2-4 hrs 1-2 hrs
    Oral 19-40 min 19-40 min 19-60 min 30-60 min 2-4 hrs 1-2 hrs
    Intramuscular 1-4 min 4-10 min 19-60 min 30-60 min 2-4 hrs 1-2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 4.9
    Moderate+ 5/10

    Strong dissociative depth and motor impairment with moderate mania

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection visual disconnection physical autonomy spatial disorientation +2 more
    ⚠ Mania / Compulsion ×1
    6
    disinhibition stimulation euphoria
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 2-MeO-Ketamine
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~30d

    Dissociatives develop tolerance rapidly with repeated use; spacing multi‑week breaks helps. Cross‑tolerance is expected across NMDA‑antagonists. Data for 2‑MeO‑K specifically are anecdotal; figures above extrapolate from ketamine user data.

    Cross-Tolerances

    Ketamine
    70%
    DXM
    50%
    MXE
    60%
    Other NMDA‑antagonist dissociatives
    50%

    Effects TheDrug.Wiki

    Positive
    • Pain relief
    • Physical euphoria
    • Stimulation
    • Analgesia
    Negative
    • Nausea
    • Numbness
    • Loss of balance
    • Increased heart rate
    Neutral
    • Physical disconnection
    • Sedation
    Positive
    • Euphoria
    • Cognitive euphoria
    Negative
    • Motor control loss
    • Thought disorganization
    • Depersonalization
    • Derealization
    • Memory suppression
    • Amnesia
    Neutral
    • Physical autonomy
    • Time distortion
    Positive
    • Increased music appreciation
    • Tactile enhancement
    Negative
    • Tactile suppression
    • Spatial disorientation
    • Double vision
    • Cognitive dysphoria
    • Disinhibition
    Neutral
    • Visual disconnection
    • Internal hallucination
    • Auditory distortion

    Combinations TripSit

    2-MeO-Ketamine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 Bluelight 📖 PsychonautWiki