25I-NBOMe - Substance Search

Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

2C-I is a Schedule I controlled substance in the United States and many other countries. Use precise dosing methods like volumetric dosing due to dose sensitivity. 2C-I is distinct from 25I-NBOMe (2C-I-NBOMe), which is significantly more potent and dangerous.

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Sublingual	200-500µg	500-700µg	700-1000µg	1000µg+
Buccal	200-500µg	500-700µg	700-1000µg	1000µg+
Insufflated	200-500µg	500-700µg	700µg+	-

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Sublingual	0.25-2 hrs	0.5-2 hrs	2-4 hrs	1-4 hrs	72-144 hrs	5-10 hrs
Buccal	0.25-2 hrs	0.5-2 hrs	2-4 hrs	1-4 hrs	72-144 hrs	3.8-12 hrs
Oral	15-45 min	45-90 min	3-5 hrs	2-3 hrs	6-24 hrs	5-10 hrs
Insufflated	6-12 min	12-30 min	1-2 hrs	2-3 hrs	1-7 hrs	4-6 hrs

Effect Profile

288 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 226 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 8.8

Intense+ 9/10

Strong visuals, headspace, auditory effects, and body load

Visual Intensity ×3

10

internal hallucinations colour enhancement autonomous entities drifting tracers synaesthesia +9 more

Headspace Depth ×3

10

conceptual thinking introspection thought connectivity recursion emotion enhancement perspective alterations +3 more

Auditory Effects ×1

10

auditory distortion auditory enhancement auditory hallucinations auditory hallucination synaesthesia

⚠ Body Load / Somatic Effects ×1

10

nausea vasoconstriction temperature regulation suppression muscle tension increased heart rate

Based on reports from:

Effect Index Ego Death and a Total Breakthrough in the Snow Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 25I-NBOMe

Tolerance

Build-up develops rapidly after a single use; redosing is especially dangerous

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 0h Half tolerance 3d Baseline ~7d

Tolerance builds rapidly after a single dose and partially recovers over 3–7 days; near‑baseline typically returns after 1–2 weeks. Cross‑tolerance with other serotonergic psychedelics is expected. Values are heuristic (community/HR synthesis). Data quality: low/anecdotal.

Cross-Tolerances

LSD

70%

Psilocybin

60%

2C-x

50%

DOx

50%

Other NBOMe compounds

80%

Effects Erowid Bluelight

Aggregated from 226 Erowid and 62 Bluelight experience reports

Positive Effects 61

Visual Distortions 72.1% 82%

Color Enhancement 59.8% 85%

Music Enhancement 46.4% 84%

Euphoria 45.0% 85%

Stimulation 38.0% 79%

Empathy 31.2% 80%

Closed-Eye Visuals 30.1% 89%

Focus Enhancement 28.8% 70%

Auditory Effects 27.2% 82%

Tactile Enhancement 26.4% 82%

Introspection 23.9% 78%

Open-Eye Visuals 19.9% 87%

Body High 19.6% 84%

Surface Breathing 18.0% 84%

Patterning 18.0% 84%

Visual Trails 16.0% 87%

Geometric Imagery 16.0% 85%

Thought Acceleration 14.0% 80%

Awe 12.0% 82%

Melting/flowing 10.0% 85%

Adverse Effects 56

Anxiety 61.2% 83%

Confusion 41.7% 80%

Nausea 26.1% 88%

Body Load 18.0% 83%

Muscle Tension 15.2% 85%

Fear 14.0% 85%

Vomiting 14.0% 91%

Panic 14.0% 91%

Thought Loops 13.4% 81%

Depersonalization 12.0% 83%

Increased Heart Rate 10.6% 70%

Paranoia 10.0% 78%

Tingling 10.0% 81%

Thought Disorganization 10.0% 79%

Sweating 9.4% 87%

Entity Imagery 8.0% 81%

Tremor 8.0% 80%

Headache 8.0% 78%

Insomnia 8.0% 82%

Jaw Clenching 7.9% 80%

Combinations TripSit

Trip Reports Effect Index

Ego Death and a Total Breakthrough in the Snow Anonymous Reader

25I-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit 📖 Bluelight