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    Disclaimer
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25iP-NBOMe

    Aliases: 25ip, 2c-ip-nbome, Nbome-2c-ip

    Psychedelic Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    25iP-NBOMe is extremely potent and dangerous. NBOMes have been associated with numerous deaths and hospitalizations at doses that users believed to be safe. Always use a 0.001 g analytical scale or volumetric dosing for accuracy.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Buccal 300-750ug 750-1000ug 1000-1500ug 1500ug+(highrisk)+
    Intranasal - - - 900ug+(highrisk)+
    Oral - - - 2500ug+(unpredictable)+
    Sublingual 300-750ug 750-1000ug 1000-1500ug 1500ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Buccal 20-45 min 30-60 min 2-4 hrs 2-3 hrs 6-12 hrs 4.8-8.8 hrs
    Intranasal 5-15 min 15-30 min 2-4 hrs 2-3 hrs 6-12 hrs 4.3-7.8 hrs
    Oral 45-90 min 60-90 min 2-4 hrs 2-3 hrs 6-12 hrs 5.8-10 hrs
    Sublingual 30-60 min - 5-7 hrs - 1-12 hrs 5.5-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.4
    Moderate+ 5/10

    Strong visuals and body load with mild auditory effects, low headspace

    Visual Intensity ×3
    10
    visual geometry internal hallucinations color enhancement drifting tracers pattern recognition enhancement +4 more
    Headspace Depth ×3
    3
    thought loops time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    10
    vasoconstriction nausea temperature regulation suppression muscle tension teeth grinding increased heart rate
    Stimulant 2.6
    Light+ 3/10

    Strong anxiety/jitters with moderate euphoria, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    6
    physical euphoria euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate teeth grinding vasoconstriction muscle tension +1 more
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25iP-NBOMe
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 0h Half tolerance 7d Baseline ~14d

    Acute tolerance develops rapidly after a single strong session (typical of 5‑HT2A agonists). Substantial tolerance persists for days and decays over 1–3+ weeks; precise kinetics for 25iP‑NBOMe are not characterized. Cross‑tolerance with other psychedelics is expected but unquantified; ratios are heuristic. Data quality relies on class‑level evidence and user reports, not controlled human studies.

    Cross-Tolerances

    LSD
    50%
    Psilocybin
    40%
    Other 5-HT2A psychedelics (NBOMe/phenethylamine)
    60%

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Physical Euphoria
    • Mental/physical stimulation
    Negative
    • Vasoconstriction
    • Increased Heart Rate
    • Increased Blood Pressure
    • Muscle Tension
    • Nausea
    • Temperature Regulation Suppression
    • Teeth Grinding
    • Insomnia
    • Pupil dilation
    • Restlessness
    • Sweating/chills
    Neutral
    • Difficulty Urinating
    • Decreased appetite
    Positive
    • Euphoria
    • Empathy Enhancement
    • Empathy
    • Insight
    Negative
    • Anxiety
    • Confusion
    • Thought Loops
    Neutral
    • Time Distortion
    • Change in perception
    • Ego softening
    Positive
    • Visual Geometry
    • Color Enhancement
    • Pattern Recognition Enhancement
    • Acuity Enhancement
    • Tracers
    • Tactile Enhancement
    • Bodily Control Enhancement
    • Brightened colour
    • Enhanced tactile sensation
    Neutral
    • Drifting
    • After Images
    • Symmetrical Texture Repetition
    • Scenery Slicing
    • Internal Hallucinations
    • Auditory Distortion
    • Closed/Open eye visuals

    Combinations TripSit

    25iP-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki