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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2C-N

    Aliases: 4-nitro-2,5-dimethoxyphenethylamine, 2cn

    Summary TheDrug.Wiki TripSit

    2C-N is a rare psychedelic of the 2C-x family with significantly higher dosage requirements than other 2C compounds (100-150 mg vs 10-30 mg for most 2Cs). It is characterized by its distinctive orange to yellow color due to the nitro group. User reports describe mild-moderate psychedelic effects with notable body load and physical discomfort.

    Perspectives

    “This came on very fastβ€”I was aware of it within a half hour, and it got as far as it would go by an hour. There are similarities to MDMA, but missing is the benign anti-stress component. I am light-headed, and there just might be a little eye wiggling. And then it dropped right off to nothing within a couple of hours.”

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 100mg 100-125mg 125-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-60 min 30-60 min 1-3 hrs 2-3 hrs 1-2 hrs 4-6 hrs

    Effect Profile

    3 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.0
    Moderate+ 5/10

    Strong visuals with moderate body load, low headspace

    Visual Intensity ×3
    10
    color enhancement drifting tracers visual enhancement pattern recognition enhancement color shifting +1 more
    Headspace Depth ×3
    2
    confusion time distortion
    Auditory Effects ×1
    0
    Body Load / Somatic Effects ×1
    6
    nausea muscle tension bodily pressure

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks β€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Rapid tolerance and cross‑tolerance typical of 5‑HT2A agonists; model based on human/animal literature for classical psychedelics rather than 2C‑N-specific trials; spacing 10–14 days is a prudent rule-of-thumb.

    Cross-Tolerances

    Effects Erowid

    Aggregated from 3 Erowid experience reports

    Positive Effects 0

    Adverse Effects 1

    Nausea 100.0% 70%

    Combinations TripSit

    PiHKAL / TiHKAL Shulgin

    PiHKAL #34: 2C-N

    “This came on very fastβ€”I was aware of it within a half hour, and it got as far as it would go by an hour. There are similarities to MDMA, but missing is the benign anti-stress component. I am light-headed, and there just might be a little eye wiggling. And then it dropped right off to nothing within a couple of hours.”

    β€” Alexander Shulgin, PiHKAL (with 120 mg)

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