**Preface:** 2,5-dimethoxy-4-nitrophenethylamine is an unpopular member of the 2CΒ family. It was made available for a short period of time by some RC vendor(s) many years ago but never reached the popularity of other analogs such as 2C-E, 2C-I or 2C-T-7.
2C-N
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 4-nitro-2,5-dimethoxyphenethylamine, 2cn
Summary
2C-N is a rare psychedelic of the 2C-x family with significantly higher dosage requirements than other 2C compounds (100-150 mg vs 10-30 mg for most 2Cs). It is characterized by its distinctive orange to yellow color due to the nitro group. User reports describe mild-moderate psychedelic effects with notable body load and physical discomfort.
Perspectives
“This came on very fastβI was aware of it within a half hour, and it got as far as it would go by an hour. There are similarities to MDMA, but missing is the benign anti-stress component. I am light-headed, and there just might be a little eye wiggling. And then it dropped right off to nothing within a couple of hours.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100mg | 100-125mg | 125-150mg | 150mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 19-60 min | 30-60 min | 1-3 hrs | 2-3 hrs | 4-6 hrs |
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
5.0
Moderate+
5/10
Strong visuals with moderate body load, low headspace
Visual Intensity
×3
10
color enhancement
drifting
tracers
visual enhancement
pattern recognition enhancement
color shifting
+1 more
Headspace Depth
×3
2
confusion
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
6
nausea
muscle tension
bodily pressure
Based on reports from:
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Name
2C-N
Unit
mg
Description
2C-N Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 100 Β· common 100-125 Β· strong 125-150 Β· heavy 150+ Oral duration: onset 0.32-1h Β· come-up 0.5-1h Β· peak 1-3h Β· offset 2-3h Β· total 4-6h Β· after-effects 1-2h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 112.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops rapidly after a single use
Reset
7β14 days for baseline
Tolerance Decay
Full tolerance
3d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Rapid tolerance and crossβtolerance typical of 5βHT2A agonists; model based on human/animal literature for classical psychedelics rather than 2CβN-specific trials; spacing 10β14 days is a prudent rule-of-thumb.
Cross-Tolerances
Effects
Aggregated from 3 Erowid experience reports
Positive Effects 0
Adverse Effects 1
Nausea
100.0%
70%
Combinations
Cross-Check 2C-N with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 3 reports 1 positive 2 cautionary visit
Sunday, May 9, 2004 140mg of 2, 5-dimethoxy-4-nitrophenethylamine I awoke, and without prior planning I went to my cabinet to retrieve and swallow a capsule containing beautiful pumpkin-colored crystals of 2C-N hcl. I had nothing in my stomach but a little bit of an apple when I ate with the pill.
I recently had a trip on 2C-N. I dont remember too many details; the trip itself was about 5 weeks ago. The trip lasted a fairly short while - after about 4 hours I was well and more than able to function. The trip started slowly but as it started to pick up, the come up was exponential.
Bluelight 5 threads 5 neutral visit
Subtle Grace, Gentle Power First 2C-N Trial, at 60mg, Oral 3-20-2022 by Xorkoth β About a week ago, I was very fortunate to receive a gift in the mail from the drug fairies' chemistry division.
Head On Second 2C-N Trial, at 130mg, Oral 4-2-2022 by Xorkoth (Link to my first trial for reference) β Recently I had the good fortune to be gifted with 350mg of 2C-N nitrate. It is a bright, beautiful yellow powder, similar otherwise in appearance and texture to the other 2C-Xs.
Preface: 2,5-dimethoxy-4-nitrophenethylamine is an unpopular member of the 2Cβ family. It was made available for a short period of time by some RC vendor(s) many years ago but never reached the popularity of other analogs such as 2C-E, 2C-I or 2C-T-7.
2C-N - First Time - Childhood Memories Sunday, May 9, 2004 140mg of 2, 5-dimethoxy-4-nitrophenethylamine I awoke, and without prior planning I went to my cabinet to retrieve and swallow a capsule containing beautiful pumpkin-colored crystals of 2C-N hcl.
2C-N - first time - 100mg Took 100mg (hcl salt) in a gelcap around 8:30pm, started feeling something slightly within 15-20 minutes. Its now an hour later and has developed into something not sure if it will go up any higher, enhanced colors, minor trails, no bad body load or anything although the "body buzz" is quite s...
Bluelight Reference Guide
Phenethylamines The Big & Dandy 2C-N Thread - The Long-Lost Family Member.
2,5-dimethoxy-4-nitrophenethylamine (2C-N) is an uncommon phenethylamine and member of the 2C-family, most of which were created by our beloved Alexander Shulgin. Shulgin stated that the common dose range for 2C-N hydrochloride is somewhere between 100-150 mg, and the duration is around 4-6 hours.
Read full thread on Bluelight βPiHKAL / TiHKAL
PiHKAL #34: 2C-N
“This came on very fastβI was aware of it within a half hour, and it got as far as it would go by an hour. There are similarities to MDMA, but missing is the benign anti-stress component. I am light-headed, and there just might be a little eye wiggling. And then it dropped right off to nothing within a couple of hours.”
2C-N's nerd page
Pharmacology, chemical data, effect profiles, and more
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