3-CAF
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 20 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 20 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 3-chloroamphetamine
Summary
3-CAF is a positional isomer of the neurotoxic para-chloramphetamine (PCA). In vitro work (Urban et al., 2012) indicates potent serotonin and moderate dopamine/noradrenaline release (EC50 ≈ 35 nM for 5-HT, 280 nM for DA). Neurotoxicity appears reduced compared with PCA but long-term serotonergic depletion has been observed in rat cortex at ≥10 mg/kg (Kindred et al., 2015).
Dose Information
Dose basis. Human data are scarce; ranges largely derive from scattered user reports. Always use an accurate 0.001 g scale, consider an allergy test (≈1–2 mg), and titrate cautiously. Insufficient evidence to support frequent redosing. Faster onset with steeper cardiovascular load and more local irritation. Volumetric dosing recommended to avoid overestimation from hygroscopic powders; avoid repeated lines due to mucosal injury risk. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-35mg | 35mg+ (not advised) |
| Insufflated | 2-5mg | 5-12mg | 12-20mg | 20mg+ (not advised) |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-45 min | 1.5-3 hrs | 1-2 hrs | 2.83-5.75 hrs |
| Insufflated | 20-45 min | 1.5-3 hrs | 1-2 hrs | 2.83-5.75 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild visuals with low body load and headspace
Moderate stimulation and sensory enhancement with low empathy and euphoria
Strong anxiety/jitters with moderate stimulation, mild euphoria, low focus
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3-CAF Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 5 · light 5-10 · common 10-20 · strong 20-35 · heavy 35+ (not advised) Insufflated dose (mg): threshold 2 · light 2-5 · common 5-12 · strong 12-20 · heavy 20+ (not advised) Oral duration: onset 20-45m · peak 1.5-3h · offset 1-2h · total 2.83-5.75h · after-effects 1-4m Insufflated duration: onset 20-45m · peak 1.5-3h · offset 1-2h · total 2.83-5.75h · after-effects 1-4m Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Based on general entactogen/stimulant patterns: acute tolerance develops within a session; partial tolerance persists days to weeks, decaying roughly over 2–6 weeks depending on use intensity, sleep, and nutrition.
Cross-Tolerances
Effects
- Increased energy and talkativeness
- Mild entactogenic body high
- Stimulation
- Pupil dilation
- Bruxism, jaw tension
- Mild hyperthermia, sweating
- Insomnia at higher doses
- Possible mild comedown dysphoria
- Increased heart rate
- Teeth grinding
- Euphoria
- Heightened empathy/sociability
- Alertness enhancement
- Wakefulness
- Motivation enhancement
- Anxiety
- Compulsive redosing
- Talkativeness
- Time distortion
- Thought acceleration
- Tactile enhancement
- Increased libido
- Increased music appreciation
- Tracers
- Color enhancement
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Tactile intensification
Combinations
Cross-Check 3-CAF with another substanceHelpful Links
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