3-CAF
Aliases: 3-chloroamphetamine
Summary
3-CAF is a positional isomer of the neurotoxic para-chloramphetamine (PCA). In vitro work (Urban et al., 2012) indicates potent serotonin and moderate dopamine/noradrenaline release (EC50 ≈ 35 nM for 5-HT, 280 nM for DA). Neurotoxicity appears reduced compared with PCA but long-term serotonergic depletion has been observed in rat cortex at ≥10 mg/kg (Kindred et al., 2015).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 35mg+(notadvised)+ |
| Insufflated | - | - | - | 20mg+(notadvised)+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 20-45 min | 1.5-3 hrs | 1-2 hrs |
| Insufflated | 20-45 min | 1.5-3 hrs | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild visuals with low body load and headspace
Moderate stimulation and sensory enhancement with low empathy and euphoria
Strong anxiety/jitters with moderate stimulation, mild euphoria, low focus
Tolerance
Tolerance Decay
Based on general entactogen/stimulant patterns: acute tolerance develops within a session; partial tolerance persists days to weeks, decaying roughly over 2–6 weeks depending on use intensity, sleep, and nutrition.
Cross-Tolerances
Effects
- Increased energy and talkativeness
- Mild entactogenic body high
- Stimulation
- Pupil dilation
- Bruxism, jaw tension
- Mild hyperthermia, sweating
- Insomnia at higher doses
- Possible mild comedown dysphoria
- Increased heart rate
- Teeth grinding
- Euphoria
- Heightened empathy/sociability
- Alertness enhancement
- Wakefulness
- Motivation enhancement
- Anxiety
- Compulsive redosing
- Talkativeness
- Time distortion
- Thought acceleration
- Tactile enhancement
- Increased libido
- Increased music appreciation
- Tracers
- Color enhancement
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Tactile intensification