Summary
3-CAF is a positional isomer of the neurotoxic para-chloramphetamine (PCA). In vitro work (Urban et al., 2012) indicates potent serotonin and moderate dopamine/noradrenaline release (EC50 ≈ 35 nM for 5-HT, 280 nM for DA). Neurotoxicity appears reduced compared with PCA but long-term serotonergic depletion has been observed in rat cortex at ≥10 mg/kg (Kindred et al., 2015). Human use reports are extremely scarce; users describe a ‘clean’, MDMA-lite empathy with typical amphetamine stimulation and minimal visuals. Marked hyperthermia and bruxism were noted at >30 mg.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 35mg+(notadvised)+ |
| Insufflated | - | - | - | 20mg+(notadvised)+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 20-45 min | 1.5-3 hrs | 1-2 hrs | 1-4 min |
| Insufflated | 20-45 min | 1.5-3 hrs | 1-2 hrs | 1-4 min |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Effects
Positive
- Increased energy and talkativeness
- Mild entactogenic body high
- Stimulation
Negative
- Pupil dilation
- Bruxism, jaw tension
- Mild hyperthermia, sweating
- Insomnia at higher doses
- Possible mild comedown dysphoria
- Increased heart rate
- Teeth grinding
Positive
- Euphoria
- Heightened empathy/sociability
- Alertness enhancement
- Wakefulness
- Motivation enhancement
Negative
- Anxiety
- Compulsive redosing
- Talkativeness
- Time distortion
- Thought acceleration
Positive
- Tactile enhancement
- Increased libido
- Increased music appreciation
- Tracers
- Color enhancement
Negative
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Tactile intensification