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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-CAF Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 30 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 3-chloroamphetamine

    Psychedelic Stimulant Research-chemical

    Summary dose.wiki

    3-CAF is a positional isomer of the neurotoxic para-chloramphetamine (PCA). In vitro work (Urban et al., 2012) indicates potent serotonin and moderate dopamine/noradrenaline release (EC50 ≈ 35 nM for 5-HT, 280 nM for DA). Neurotoxicity appears reduced compared with PCA but long-term serotonergic depletion has been observed in rat cortex at ≥10 mg/kg (Kindred et al., 2015).

    Dose Information Drugs.Wiki

    Dose basis. Oral: Human data are scarce; ranges largely derive from scattered user reports. Always use an accurate 0.001 g scale, consider an allergy test (≈1–2 mg), and titrate cautiously. Insufficient evidence to support frequent redosing. Insufflated: Faster onset with steeper cardiovascular load and more local irritation. Volumetric dosing recommended to avoid overestimation from hygroscopic powders; avoid repeated lines due to mucosal injury risk. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-20mg 20-35mg 35mg+ (not advised)
    Insufflated 2-5mg 5-12mg 12-20mg 20mg+ (not advised)
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-45 min 1.5-3 hrs 1-2 hrs 1-4 min 2.83-5.75 hrs
    Insufflated 20-45 min 1.5-3 hrs 1-2 hrs 1-4 min 2.83-5.75 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 2.8
    Light+ 3/10

    Mild visuals with low body load and headspace

    Visual Intensity ×3
    4
    color enhancement tracers
    Headspace Depth ×3
    1
    time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    3
    teeth grinding increased heart rate
    Empathogen 4.1
    Moderate 4/10

    Moderate stimulation and sensory enhancement with low empathy and euphoria

    Empathy / Social Openness ×3
    3
    heightened empathy/sociability
    Euphoria / Mood Elevation ×2
    3
    euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 4.5
    Moderate 4/10

    Moderate stimulation with strong anxiety/jitters, mild euphoria, low focus

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    3
    thought acceleration motivation enhancement
    ⚠ Anxiety / Jitters ×1
    8
    anxiety increased heart rate teeth grinding
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 2d Half tolerance 7d Baseline ~30d

    Based on general entactogen/stimulant patterns: acute tolerance develops within a session; partial tolerance persists days to weeks, decaying roughly over 2–6 weeks depending on use intensity, sleep, and nutrition.

    Cross-Tolerances

    MDMA
    MDA
    5‑APB/6‑APB
    Mephedrone (4‑MMC)

    Effects dose.wiki

    Positive
    • Increased energy and talkativeness
    Negative
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 3-CAF with another substance

    3-CAF's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3-CAF there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "3-CAF (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    3-CAF
    Unit
    mg
    Description 
    3-CAF
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5 · light 5-10 · common 10-20 · strong 20-35 · heavy 35+ (not advised)
Insufflated dose (mg): threshold 2 · light 2-5 · common 5-12 · strong 12-20 · heavy 20+ (not advised)

Oral duration: onset 20-45m · peak 1.5-3h · offset 1-2h · total 2.83-5.75h · after-effects 1-4m
Insufflated duration: onset 20-45m · peak 1.5-3h · offset 1-2h · total 2.83-5.75h · after-effects 1-4m

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.