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    Disclaimer
    ⚠ PCP and its analogues are potent dissociatives with significant risk of psychosis, violent behavior, and overdose. Effects are highly unpredictable and dose-sensitive.
    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-HO-PCP

    Aliases: 3-oh-pcp, Hydroxyphencyclidine, 3hopcp

    Summary TheDrug.Wiki TripSit PsychonautWiki

    3-HO-PCP is a potent dissociative first synthesized in 1978. Uniquely among arylcyclohexylamines, it has appreciable ΞΌ-opioid receptor activity in animal models, though the extent of opioid effects in humans remains unclear. Reports suggest it may produce more physical side effects (muscle soreness, flu-like symptoms) than related dissociatives, especially at higher doses.

    Perspectives

    “Unlike every other exclusively 3-substituted arylcyclohexamine I’ve tried, this was not functional or stimulating in the least. It was a powerful, all encompassing, annihilating experience that thrashed me about like a raft in a hurricane.”

    “This was in fact quite a decent experience, tempting a potential return.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 2-4mg 4-6mg 6-8mg 8mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-45 min 60-90 min 2-4 hrs 1-2 hrs 12-12 hrs 3-4 hrs
    Insufflated 4-19 min 30-60 min 2-3 hrs 1-2 hrs 12-12 hrs 3-4 hrs

    Effect Profile

    22 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.6
    Strong+ 7/10

    Strong dissociative depth, motor impairment, and mania with moderate insight

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection cognitive disconnection visual disconnection changes in felt gravity +4 more
    Mania / Compulsion ×1
    8
    compulsive redosing disinhibition stimulation
    Insight / Novel Thought ×2
    7
    conceptual thinking thought connectivity creativity enhancement
    Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression spatial disorientation visual disconnection double vision

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 2d Half tolerance 3d Baseline ~14d

    Tolerance builds rapidly with repeated use over days and decays over 1–2+ weeks; numbers are approximate and largely anecdotal for this specific analogue.

    Effects Erowid Bluelight

    Aggregated from 17 Erowid and 5 Bluelight experience reports

    Positive Effects 20

    Color Enhancement 52.9% 70%
    Music Enhancement 52.9% 70%
    Tactile Enhancement 47.1% 70%
    Stimulation 45.5% 80%
    Euphoria 40.9% 90%
    Introspection 40.0% 82%
    Focus Enhancement 35.3% 70%
    Empathy 35.3% 70%
    Emotional Openness 20.0% 80%
    Tinnitus 20.0% 90%
    Joy 20.0% 85%
    Mystical Quality 20.0% 90%
    Revelatory Insight 20.0% 85%
    Oneness 20.0% 85%
    Gratitude 20.0% 85%
    Peace 20.0% 90%
    Contentment 20.0% 85%
    Empathogenic Connection 20.0% 80%
    Insight 20.0% 90%
    Pain Relief 17.6% 70%

    Adverse Effects 24

    Dissociation 77.3% 90%
    Fear 60.0% 87%
    Visual Distortions 59.1% 80%
    Confusion 45.5% 92%
    Anxiety 45.4% 90%
    Vomiting 40.0% 85%
    Memory Suppression 31.8% 85%
    Psychosis 23.5% 70%
    Amnesia 20.0% 95%
    Dry Mouth 20.0% 90%
    Involuntary Movements 20.0% 85%
    Numbness 20.0% 95%
    Dizziness 20.0% 90%
    Blurred Vision 20.0% 85%
    Chills 20.0% 85%
    Body Temperature Change 20.0% 80%
    Headache 20.0% 85%
    Pressure 20.0% 90%
    Jaw Clenching 20.0% 75%
    Delusion 20.0% 95%

    Combinations TripSit

    Trip Reports Effect Index

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