For the better part of a decade, I've been fascinated by dissociatives. In high school I had a DXM habit that turned into daily use for over 3 months, which took a while for my brain to recover from. In my adult life, I took a liking to Ketamine and later Nitrous Oxide.
3-HO-PCP
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Aliases: 3-oh-pcp, Hydroxyphencyclidine, 3hopcp
Summary
3-HO-PCP is a potent dissociative first synthesized in 1978. Uniquely among arylcyclohexylamines, it has appreciable ฮผ-opioid receptor activity in animal models, though the extent of opioid effects in humans remains unclear. Reports suggest it may produce more physical side effects (muscle soreness, flu-like symptoms) than related dissociatives, especially at higher doses.
Perspectives
“Unlike every other exclusively 3-substituted arylcyclohexamine Iโve tried, this was not functional or stimulating in the least. It was a powerful, all encompassing, annihilating experience that thrashed me about like a raft in a hurricane.”
“This was in fact quite a decent experience, tempting a potential return.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-4mg | 4-6mg | 6-8mg | 8mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 60-90 min | 2-4 hrs | 1-2 hrs | 3-4 hrs |
| Insufflated | 4-19 min | 30-60 min | 2-3 hrs | 1-2 hrs | 3-4 hrs |
Effect Profile
22 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.6
Strong+
7/10
Strong dissociative depth, motor impairment, and mania with moderate insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
changes in felt gravity
+4 more
Mania / Compulsion
×1
8
compulsive redosing
disinhibition
stimulation
Insight / Novel Thought
×2
7
conceptual thinking
thought connectivity
creativity enhancement
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
spatial disorientation
visual disconnection
double vision
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2โ4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
2d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance builds rapidly with repeated use over days and decays over 1โ2+ weeks; numbers are approximate and largely anecdotal for this specific analogue.
Cross-Tolerances
Effects
Aggregated from 17 Erowid and 5 Bluelight experience reports
Positive Effects 20
Color Enhancement
52.9%
70%
Music Enhancement
52.9%
70%
Tactile Enhancement
47.1%
70%
Stimulation
45.5%
80%
Euphoria
40.9%
90%
Introspection
40.0%
82%
Focus Enhancement
35.3%
70%
Empathy
35.3%
70%
Emotional Openness
20.0%
80%
Tinnitus
20.0%
90%
Joy
20.0%
85%
Mystical Quality
20.0%
90%
Revelatory Insight
20.0%
85%
Oneness
20.0%
85%
Gratitude
20.0%
85%
Peace
20.0%
90%
Contentment
20.0%
85%
Empathogenic Connection
20.0%
80%
Insight
20.0%
90%
Pain Relief
17.6%
70%
Adverse Effects 24
Dissociation
77.3%
90%
Fear
60.0%
87%
Visual Distortions
59.1%
80%
Confusion
45.5%
92%
Anxiety
45.4%
90%
Vomiting
40.0%
85%
Memory Suppression
31.8%
85%
Psychosis
23.5%
70%
Amnesia
20.0%
95%
Dry Mouth
20.0%
90%
Involuntary Movements
20.0%
85%
Numbness
20.0%
95%
Dizziness
20.0%
90%
Blurred Vision
20.0%
85%
Chills
20.0%
85%
Body Temperature Change
20.0%
80%
Headache
20.0%
85%
Pressure
20.0%
90%
Jaw Clenching
20.0%
75%
Delusion
20.0%
95%
Combinations
Cross-Check 3-HO-PCP with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 8 neutral visit
In the time since my last report regarding 3-HO-PCP, I have dabbled with it many times at generally low doses. Generally, I am familiar and comfortable with 6-8mg oral doses. These provide functional and manageable dissociation that is generally predictable and never overwhelming.
T0:00- I cut a line of powder and snort it. This substance is painless, as though I wasnยt snorting anything. No pain, no bitterness, no discomfort even, it was just like breathing air. What an odd premonition of the void to come. T0:12- The first notes hit, a light and floaty feeling.
It's the middle of the week and I've just come back from a long and tiring day chock full of lectures. What better way to unwind than with a worryingly large dose of 3-HO-PCP? T0:00 - I measure some 3-HO-PCP solution in propylene glycol and swallow a 16mg dose.
I got a sample of etizolam from a vendor the morning before this night. Took the etizolam early in the day, fell asleep and woke up at good old 1:00 AM. Well fuck, here I am wide away at 1:00 AM. What to do? Might as well take a high dose of 3-HO-PCP. t :00 I dose 15mg orally at 1:30 AM.
[Erowid Note: Two samples of powder (even of the same chemical) with equivalent volumes won't necessarily weigh the same. For this reason, eyeballing is an inaccurate and potentially dangerous method of measuring, particularly for substances that are active in very small amounts.
Little background with me and dissociatives: The only dissociative I've tried before was Ketamine and I found it pretty boring , I always ended up walking funny because I felt so heavy, but I didnt like anything from it, really. Even music sounded weird to me. Well theres my little experiment with 3-HO-PCP.
We ordered 1g of 3-HO-PCP from an on-line vendor. We didn't test it, but I'm pretty sure it was the real deal. We (wife and I) started off with a moderate dose, sniffing a little less than 10mg. After 15-20 minutes I could feel it but it was mild.
Bluelight Reference Guide
Dissociatives The Big & Dandy 3-HO-PCP Thread
3-HO- PCP Dosing Graph ________________________ Graph courtesy of @sernyl Here's another post on 3-HO-PCP from an intrepid psychonaut (post is 2/3 of the way down this page): Hugo24 said: My first 1mg dose of 3-HO-PCP produced mostly placebo effects,but then, I was sure something went on.
Read full thread on Bluelight โ
3-HO-PCP's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 3-HO-PCP? Let us know. Reports are reviewed by moderators — this is not posted publicly.