For the better part of a decade, I've been fascinated by dissociatives. In high school I had a DXM habit that turned into daily use for over 3 months, which took a while for my brain to recover from. In my adult life, I took a liking to Ketamine and later Nitrous Oxide.
3-HO-PCP
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: 3-oh-pcp, Hydroxyphencyclidine, 3hopcp
Summary
3-HO-PCP is a potent dissociative first synthesized in 1978. Uniquely among arylcyclohexylamines, it has appreciable ΞΌ-opioid receptor activity in animal models, though the extent of opioid effects in humans remains unclear. Reports suggest it may produce more physical side effects (muscle soreness, flu-like symptoms) than related dissociatives, especially at higher doses.
Perspectives
“Unlike every other exclusively 3-substituted arylcyclohexamine Iβve tried, (3-HO-PCE, 3-MeO-PCE, 3-MeO-PCP), this was not functional or stimulating in the least. It was a powerful, all encompassing, annihilating experience that thrashed me about like a raft in a hurricane.”
“This was in fact quite a decent experience, tempting a potential return.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-4mg | 4-6mg | 6-8mg | 8mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — Drugs.Wiki, PsychonautWikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 60-90 min | 2-4 hrs | 1-2 hrs | 3-4 hrs |
| Insufflated | 4-19 min | 30-60 min | 2-3 hrs | 1-2 hrs | 3-4 hrs |
Effect Profile
12 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.6
Strong+
7/10
Strong dissociative depth with strong motor impairment and mania, moderate insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
changes in felt gravity
+4 more
Mania / Compulsion
×1
8
compulsive redosing
disinhibition
stimulation
Insight / Novel Thought
×2
7
conceptual thinking
thought connectivity
creativity enhancement
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
spatial disorientation
visual disconnection
double vision
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2β4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
2d
Half tolerance
7d
Baseline
~14d
Tolerance builds rapidly with repeated use over days and decays over 1β2+ weeks; numbers are approximate and largely anecdotal for this specific analogue.
Cross-Tolerances
Effects
Aggregated from 7 single-substance Erowid and 5 Bluelight experience reports; 10 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Too few reports for bars: these effects come from 7 single-substance Erowid and 5 Bluelight reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
Effect glossary — · full glossary
Positive Effects 17
4 of 7
–
4 of 7
–
3 of 7
–
5 of 12
90%
2 of 5
80%
2 of 5
82%
1 of 5
80%
1 of 5
90%
1 of 5
85%
1 of 5
90%
1 of 5
85%
1 of 5
85%
1 of 5
85%
1 of 5
90%
1 of 5
85%
1 of 5
80%
1 of 5
90%
Adverse Effects 22
10 of 12
90%
3 of 5
87%
7 of 12
92%
7 of 12
80%
2 of 5
85%
4 of 12
90%
1 of 5
95%
1 of 5
90%
1 of 5
85%
1 of 5
95%
1 of 5
90%
1 of 5
85%
1 of 5
85%
1 of 5
80%
1 of 5
85%
1 of 5
90%
1 of 5
85%
1 of 5
75%
1 of 5
95%
1 of 5
90%
Show 2 more adverse effects
1 of 5
90%
1 of 5
85%
Also reported in combinations. In the 10 3-HO-PCP reports where another drug was taken too, 2 mention hospital, emergency services or an overdose, 0 a seizure and 2 psychosis (too few reports for percentages). In the 7 single-substance reports: 0, 0 and 2. These are not in the figures above: they cannot be put down to 3-HO-PCP alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check 3-HO-PCP with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 7 reports 1 positive 3 neutral 3 cautionary visit
In the time since my last report regarding 3-HO-PCP, I have dabbled with it many times at generally low doses. Generally, I am familiar and comfortable with 6-8mg oral doses. These provide functional and manageable dissociation that is generally predictable and never overwhelming.
It's the middle of the week and I've just come back from a long and tiring day chock full of lectures. What better way to unwind than with a worryingly large dose of 3-HO-PCP? T0:00 - I measure some 3-HO-PCP solution in propylene glycol and swallow a 16mg dose.
I got a sample of etizolam from a vendor the morning before this night. Took the etizolam early in the day, fell asleep and woke up at good old 1:00 AM. Well fuck, here I am wide away at 1:00 AM. What to do? Might as well take a high dose of 3-HO-PCP. t :00 I dose 15mg orally at 1:30 AM.
[Erowid Note: Two samples of powder (even of the same chemical) with equivalent volumes won't necessarily weigh the same. For this reason, eyeballing is an inaccurate and potentially dangerous method of measuring, particularly for substances that are active in very small amounts.
Little background with me and dissociatives: The only dissociative I've tried before was Ketamine and I found it pretty boring , I always ended up walking funny because I felt so heavy, but I didnt like anything from it, really. Even music sounded weird to me. Well theres my little experiment with 3-HO-PCP.
We ordered 1g of 3-HO-PCP from an on-line vendor. We didn't test it, but I'm pretty sure it was the real deal. We (wife and I) started off with a moderate dose, sniffing a little less than 10mg. After 15-20 minutes I could feel it but it was mild.
Dose.wiki 2 reports 2 neutral visit
Unlike every other exclusively 3-substituted arylcyclohexamine Iβve tried, (3-HO-PCE, 3-MeO-PCE, 3-MeO-PCP), this was not functional or stimulating in the least. It was a powerful, all encompassing, annihilating experience that thrashed me about like a raftβ¦
I spent most of the day relaxing and programming afterwards, feeling very rejuvenated and in a wonderful mood. I feel like this was the perfect substance for getting settled back home after a month long vacation, and feel it was a good choice despite notβ¦
Bluelight Reference Guide
Dissociatives The Big & Dandy 3-HO-PCP Thread
3-HO- PCP Dosing Graph ________________________ Graph courtesy of @sernyl Here's another post on 3-HO-PCP from an intrepid psychonaut (post is 2/3 of the way down this page): Hugo24 said: My first 1mg dose of 3-HO-PCP produced mostly placebo effects,but then, I was sure something went on.
Read full thread on Bluelight β
3-HO-PCP's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has 3-HO-PCP, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "3-HO-PCP (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Duration (reference)
3-HO-PCP: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Insufflated duration: onset 4-19m Β· come-up 0.5-1h Β· peak 2-3h Β· offset 1-2h Β· total 3-4h Β· after-effects 12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Ranges are harm-reduction guidance, not a prescription.
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