Summary
4-CMC is a synthetic cathinone structurally similar to mephedrone (4-MMC) and para-chloromethamphetamine. Research indicates it is neurotoxic through oxidative stress mechanisms and is more cytotoxic than 4-MMC. Common adverse effects include increased blood pressure, tachycardia, hyperthermia, anxiety, and paranoia. Fatalities have been reported in cases of overdose and polydrug use. The substance has been placed in Schedule II by the UNODC and is controlled in many countries.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-50mg | 50mg-100mg | 100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-3 hrs | 1-2 hrs | 24 hrs |
| Insufflated | 2-10 min | 10-20 min | 1-2 hrs | 1-2 hrs | 24 hrs |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Stimulation
- Increased energy/alertness
Negative
- Teeth grinding
- Increased heart rate
- Vasoconstriction
- Insomnia
- Weight loss
- Sweating
- Bruxism
- Decreased need for sleep
- Decreased appetite
- Disturbed sleep patterns
- Itchiness
Positive
- Euphoria
- Empathy
- Increased sociability
- Focus enhancement
- Motivation enhancement
- Mood lift
Negative
- Anxiety
- Paranoia
- Compulsive redosing
- Aggressiveness
- Excessive talking
- Moodiness
Positive
- Increased libido
- Tactile enhancement
- Increased music appreciation
- Tracers
Negative
- Appetite suppression
- Dehydration
- Light sensitivity
- Disinhibition
- Increased sexuality
- Visual and auditory hallucinations