4-CMC
Aliases: Clephedrone, 4-chloromethcathinone, 4cmc
Summary
4-CMC is a synthetic cathinone structurally similar to mephedrone (4-MMC) and para-chloromethamphetamine. Research indicates it is neurotoxic through oxidative stress mechanisms and is more cytotoxic than 4-MMC. Common adverse effects include increased blood pressure, tachycardia, hyperthermia, anxiety, and paranoia.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-50mg | 50mg-100mg | 100mg | 100mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-3 hrs | 1-2 hrs |
| Insufflated | 2-10 min | 10-20 min | 1-2 hrs | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild empathy, euphoria, stimulation, and sensory enhancement
Strong anxiety/jitters with moderate euphoria, mild focus, low stimulation
Tolerance
Tolerance Decay
Anecdotal stimulant/entactogen pattern: tolerance rises rapidly with repeated dosing across days and decays over 1–2 weeks. Data quality is low; spacing at least 7–14 days is prudent to reduce tolerance and adverse effects.
Cross-Tolerances
Effects
- Stimulation
- Increased energy/alertness
- Teeth grinding
- Increased heart rate
- Vasoconstriction
- Insomnia
- Weight loss
- Sweating
- Bruxism
- Decreased need for sleep
- Decreased appetite
- Disturbed sleep patterns
- Itchiness
- Euphoria
- Empathy
- Increased sociability
- Focus enhancement
- Motivation enhancement
- Mood lift
- Anxiety
- Paranoia
- Compulsive redosing
- Aggressiveness
- Excessive talking
- Moodiness
- Increased libido
- Tactile enhancement
- Increased music appreciation
- Tracers
- Appetite suppression
- Dehydration
- Light sensitivity
- Disinhibition
- Increased sexuality
- Visual and auditory hallucinations