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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-CMC Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical

    Aliases: Clephedrone, 4-chloromethcathinone, 4cmc

    Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    4-CMC is a synthetic cathinone structurally similar to mephedrone (4-MMC) and para-chloromethamphetamine. Research indicates it is neurotoxic through oxidative stress mechanisms and is more cytotoxic than 4-MMC. Common adverse effects include increased blood pressure, tachycardia, hyperthermia, anxiety, and paranoia.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 30-50mg 50mg-100mg 100mg 100mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 20-60 min 30-60 min 1-3 hrs 1-2 hrs 24 hrs
    Insufflated 2-10 min 10-20 min 1-2 hrs 1-2 hrs 24 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 5.0
    Moderate+ 5/10

    Mild empathy, euphoria, stimulation, and sensory enhancement

    Empathy / Social Openness ×3
    5
    empathy increased sociability
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    5
    stimulation teeth grinding increased heart rate
    Sensory Enhancement ×1
    5
    tactile enhancement increased libido
    Stimulant 4.1
    Moderate 4/10

    Strong anxiety/jitters with moderate euphoria, mild focus, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria mood lift motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety paranoia teeth grinding increased heart rate bruxism vasoconstriction +1 more
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4-CMC
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 2d Half tolerance 3d Baseline ~7d

    Anecdotal stimulant/entactogen pattern: tolerance rises rapidly with repeated dosing across days and decays over 1–2 weeks. Data quality is low; spacing at least 7–14 days is prudent to reduce tolerance and adverse effects.

    Cross-Tolerances

    Other cathinones
    60%
    MDMA
    50%
    Amphetamines
    40%

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Increased energy/alertness
    Negative
    • Teeth grinding
    • Increased heart rate
    • Vasoconstriction
    • Insomnia
    • Weight loss
    • Sweating
    • Bruxism
    Neutral
    • Decreased need for sleep
    • Decreased appetite
    • Disturbed sleep patterns
    • Itchiness
    Positive
    • Euphoria
    • Empathy
    • Increased sociability
    • Focus enhancement
    • Motivation enhancement
    • Mood lift
    Negative
    • Anxiety
    • Paranoia
    • Compulsive redosing
    • Aggressiveness
    Neutral
    • Excessive talking
    • Moodiness
    Positive
    • Increased libido
    • Tactile enhancement
    • Increased music appreciation
    • Tracers
    Negative
    • Appetite suppression
    • Dehydration
    • Light sensitivity
    • Disinhibition
    Neutral
    • Increased sexuality
    • Visual and auditory hallucinations

    Combinations TripSit

    Cross-Check 4-CMC with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Bluelight 1 thread 1 neutral visit
    4 Cmc Two Tests 50mgs 100mg 100mg First Time 4 Cmc Test Runs neutral

    Posting this for a friend. For clarity he is 24, male, 130lbs/59kg's. Enjoy. 4-CMC Test #1 Dose: 50mg Time of dose 11:56pm on August 1st, 2014 Oral dose (Parachute) (Times listed are based off the time since I dosed.) ~20 minutes in feel very low level of body temp changing, head feeling warm but very very slight.

    scraped 2026-03-14
    4-CMC's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki