Summary
Pharmacology is presumed to involve mixed monoamine reuptake inhibition and releasing action with NET≈DAT>SERT, similar to 4-MEC but slightly less potent and longer lasting due to the ethyl para-substitution. Limited formal toxicology data exists; acute risks mirror other cathinones including tachycardia, hypertension, hyperthermia, vasoconstriction, bruxism, and potential serotonin syndrome when mixed with serotonergics. Hydration, temperature monitoring, and magnesium supplementation for jaw tension are advisable. Avoid consecutive-day use. Very little peer-reviewed data exists; all dosage and duration figures are extrapolated from seizure reports and small user samples—start with low doses.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 10-30 min | 20-40 min | 1-3 hrs | 1-2 hrs | 2-24 hrs |
| Insufflated | 1-5 min | 5-15 min | 1-3 hrs | 1-2 hrs | 2-24 hrs |
| Rectal | 5-15 min | 15-30 min | 1-3 hrs | 1-2 hrs | 2-24 hrs |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Stimulation
- Physical Euphoria
Negative
- Teeth Grinding
- Vasoconstriction
- Pupil Dilation
- Increased Heart Rate
- Temperature Regulation Suppression
- Increased heart rate
- Teeth grinding
- Pupil dilation
Positive
- Cognitive Euphoria
- Empathy, Affection, and Sociability Enhancement
- Motivation Enhancement
- Focus Enhancement
Negative
- Compulsive Redosing
- Anxiety
- Motivation Suppression
- Thought Deceleration
- Irritability
- Thought Acceleration
Positive
- Increased Libido
- Tactile enhancement
- Increased music appreciation
- Increased libido
- Tracers
Negative
- Appetite Suppression
- Dehydration
- Light sensitivity
- Appetite suppression
- Disinhibition