Butylone - Substance Search

Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

Butylone is a synthetic cathinone structurally related to MDMA and methylone, but with milder entactogenic effects and stronger stimulation. It was first synthesized in 1967 but remained obscure until 2005. Reported to be less potent than methylone, with more dopaminergic stimulation and less serotonergic euphoria.

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	40-80mg	80-125mg	125-225mg	225mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	20-40 min	30-60 min	1-2 hrs	2-3 hrs	1-4 hrs	3.8-6.7 hrs

Effect Profile

31 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 31 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Empathogen 8.7

Intense+ 9/10

Strong euphoria, stimulation, and sensory enhancement with moderate empathy

Empathy / Social Openness ×3

7

empathy, love, and sociability enhancement

Euphoria / Mood Elevation ×2

10

physical euphoria cognitive euphoria

Stimulation ×1

10

stimulation teeth grinding increased heart rate

Sensory Enhancement ×1

10

tactile enhancement increased libido

Stimulant 7.8

Intense 8/10

Strong euphoria, anxiety/jitters, focus, and stimulation

Stimulation / Energy ×3

8

stimulation

Euphoria / Mood Lift ×2

10

physical euphoria cognitive euphoria motivation enhancement

Focus / Productivity ×2

9

analysis enhancement thought acceleration motivation enhancement

⚠ Anxiety / Jitters ×1

10

anxiety teeth grinding increased heart rate

Based on reports from:

Erowid Experience Reports PsychonautWiki Butylone

Tolerance

Build-up develops rapidly, often within a single session; compulsive redosing common

Reset a few days for acute tolerance

Tolerance Decay

Full tolerance 12h Half tolerance 4d Baseline ~14d

Evidence for tolerance kinetics in butylone is limited to user reports and extrapolation from other serotonergic cathinones. Acute tolerance develops within a session and across consecutive days; perceived effects drop markedly on day 2–3, with partial recovery over 1–2 weeks and closer to baseline by ~3–4 weeks. Cross‑tolerance is likely with MDMA/methylone due to overlapping transporter mechanisms. Data quality: anecdotal/theoretical.

Cross-Tolerances

MDMA

50%

Methylone

60%

Other substituted cathinones

40%

Effects Erowid

Aggregated from 31 Erowid experience reports

Positive Effects 9

Euphoria 64.5% 70%

Stimulation 58.1% 70%

Empathy 38.7% 70%

Music Enhancement 35.5% 70%

Tactile Enhancement 32.3% 70%

Focus Enhancement 25.8% 70%

Introspection 25.8% 70%

Body High 16.1% 70%

Color Enhancement 16.1% 70%

Adverse Effects 10

Anxiety 38.7% 70%

Jaw Clenching 32.3% 70%

Confusion 25.8% 70%

Increased Heart Rate 19.4% 70%

Nausea 19.4% 70%

Appetite Suppression 12.9% 70%

Memory Suppression 12.9% 70%

Headache 12.9% 70%

Pupil Dilation 9.7% 70%

Sweating 9.7% 70%

Combinations TripSit

Butylone's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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