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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Canket Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical

    Aliases: 2-fxe, 2f-o-pce, 2f-nendck, 2'-fluoro-2-oxo-pce

    Dissociative Research-chemical

    Summary TheDrug.Wiki

    2F-NENDCK is a novel dissociative first identified in Canberra, Australia in August 2022. It is a positional isomer of FXE (3'-Fluoro-2-oxo-PCE), differing only by fluorine position. In April 2023, DrugsData.org revealed that all samples previously identified as FXE actually contained 2F-NENDCK.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral BA unknown 10-25mg 25-85mg 85-130mg 130mg+
    Insufflated BA unknown 20-50mg 50-90mg 90-145mg 145mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak After Effects Total
    Oral 15-35 min 20-40 min 50-80 min - 1.5-2.5 hrs
    Insufflated 1-3 min 5-15 min 45-65 min 8-18 hrs 60-90 min

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 5.1
    Moderate+ 5/10

    Strong dissociative depth and motor impairment with mild mania

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection visual disconnection physical autonomy perception of bodily lightness +1 more
    ⚠ Mania / Compulsion ×1
    4
    disinhibition stimulation
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Canket
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 2d Half tolerance 14d Baseline ~28d

    ACHs show rapid within‑session tachyphylaxis and short‑term upregulation of tolerance; spacing use by 2–4+ weeks is commonly reported to restore responsiveness. Figures are heuristic aggregates of community data; high individual variability.

    Cross-Tolerances

    Ketamine
    70%
    DXM
    50%
    Other arylcyclohexylamines (e.g., 3‑MeO‑PCP/‑PCE, DMXE)
    60%

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    • Stimulation
    • Physical euphoria
    • Pain relief
    Negative
    • Nausea
    • Numbness
    • Loss of balance
    Neutral
    • Physical disconnection
    • Difficulty urinating
    • Sedation
    Positive
    • Minimal euphoria
    Negative
    • Cognitive impairment
    • Disorientation
    • Motor control loss
    • Dizziness
    • Confusion
    • Depersonalization
    • Derealization
    Neutral
    • Dissociation
    • Physical autonomy
    Positive
    • Perception of bodily lightness
    Negative
    • Double vision
    • Pattern recognition suppression
    • Tactile suppression
    • Dehydration
    • Spatial disorientation
    • Disinhibition
    Neutral
    • Visual distortions
    • Visual disconnection
    • Auditory distortion

    Combinations TripSit

    Cross-Check Canket with another substance

    Canket's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki