Canket - Substance Search

Summary TheDrug.Wiki

2F-NENDCK is a novel dissociative first identified in Canberra, Australia in August 2022. It is a positional isomer of FXE (3'-Fluoro-2-oxo-PCE), differing only by fluorine position. In April 2023, DrugsData.org revealed that all samples previously identified as FXE actually contained 2F-NENDCK.

Dose Information TheDrug.Wiki

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki

ROA	Onset	Comeup	Peak	Offset	After Effects
Oral	20-40 min	30-60 min	1.5-2.5 hrs	2-3 hrs	4-12 hrs
Insufflated	5-15 min	15-30 min	1.5-2 hrs	1.5-2 hrs	4-12 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Dissociative 5.1

Moderate+ 5/10

Strong dissociative depth and motor impairment with mild mania

Dissociative Depth ×3

10

depersonalization derealization physical disconnection visual disconnection physical autonomy perception of bodily lightness +1 more

⚠ Mania / Compulsion ×1

4

disinhibition stimulation

Insight / Novel Thought ×2

0

⚠ Motor / Sensory Impairment ×1

10

motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more

Based on reports from:

Erowid Experience Reports PsychonautWiki Canket

Tolerance

Build-up develops with repeated use over days to weeks

Reset 2–4 weeks for noticeable reduction

Tolerance Decay

Full tolerance 2d Half tolerance 7d Baseline ~14d

ACHs show rapid within‑session tachyphylaxis and short‑term upregulation of tolerance; spacing use by 2–4+ weeks is commonly reported to restore responsiveness. Figures are heuristic aggregates of community data; high individual variability.