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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Dextromethorphan

    Aliases: Dm, Dxm, Dex, Robo, Syrup, robotussin, robitussin

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    Dextromethorphan structure

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    DXM polistirex is an extended-release formulation where dextromethorphan is bound to a sulfonated styrene-divinylbenzene copolymer complex (an edible plastic), resulting in significantly slower absorption and prolonged effects compared to DXM HBr. Duration can extend 12-24 hours with residual effects lasting up to 48 hours. The extended-release mechanism increases the ratio of unconverted DXM to dextrorphan (DXO) in the bloodstream, producing more physical/sedating effects and less intense psychedelic/dissociative effects compared to immediate-release DXM HBr. It is more difficult to reach third plateau with polistirex preparations. Users report that approximately 1.5-2x the dose of DXM HBr may be needed to achieve equivalent effects.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral BA ~11% 100-200mg 200-400mg 400-700mg 700mg+
    Light Common Strong Heavy

    DXM Plateau Calculator TripSit

    DXM dosing is weight-based β€” the same dose can produce very different effects depending on your body weight. DXM experiences are categorised into four distinct plateaus, each with progressively more intense dissociative effects.

    1st Plateau (1.5 – 2.5 mg/kg)

    Mild stimulation, music enhancement, and a light mood lift. Often compared to a mild alcohol buzz with added euphoria. Most social of the plateaus.

    2nd Plateau (2.5 – 7.5 mg/kg)

    Euphoria, closed-eye visuals, and noticeable dissociation. Impaired motor coordination, slurred speech. Similar to being cross-faded. The most commonly explored plateau.

    3rd Plateau (7.5 – 15 mg/kg)

    Strong dissociation, altered perception of time and gravity, flanging of vision and sound, intense closed-eye hallucinations. Motor control is significantly impaired β€” you should remain seated or lying down.

    4th Plateau (15 – 20 mg/kg)

    Full dissociation comparable to a high-dose ketamine "hole". Complete out-of-body experiences, loss of contact with external reality. Dangerous β€” risk of unconsciousness, respiratory depression, and medical emergency.

    taking

    ⚠️ Deaths have been reported at doses above 25 mg/kg. Always start low. Make sure your product contains only DXM as the active ingredient β€” no acetaminophen, guaifenesin, antihistamines, or pseudoephedrine.

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-60 min 30-90 min 2.0-3.0 hrs 2.0-4.0 hrs 2.0-48.0 hrs 6.0-8.0 hrs

    Tolerance

    Build-up develops slowly over weeks of regular use; enzyme inhibition can paradoxically increase effects
    Reset 2–4 weeks for noticeable reduction

    Effects TheDrug.Wiki TripSit

    Positive
    • Physical euphoria
    • Cough suppression
    • Creativity enhancement
    Negative
    • Nausea
    • Increased perspiration
    Neutral
    • Impaired motor control
    • Sedation
    • Out-of-body experiences
    • Spontaneous bodily sensations
    • Physical disconnection
    • Itchiness
    • Difficulty urinating
    • Tactile disconnection
    Positive
    • Euphoria
    • Cognitive euphoria
    • Immersion enhancement
    • Conceptual thinking
    • Unity and interconnectedness
    Negative
    • Confusion
    • Cognitive impairment
    • Motor control loss
    • Memory suppression
    • Depersonalization
    • Derealization
    • Cognitive disconnection
    • Dizziness
    • Information processing suppression
    • Thought deceleration
    Neutral
    • Dissociation
    • Altered time perception
    • Time distortion
    • Ego death
    • Consciousness disconnection
    • Personal bias suppression
    • Perspective alterations
    • Perspective distortions
    • Physical autonomy
    Positive
    • Visual geometry
    • Increased music appreciation
    • Perception of bodily lightness
    • Auditory enhancement
    Negative
    • Spatial disorientation
    • Visual acuity suppression
    • Double vision
    • Frame rate suppression
    • Acuity suppression
    • Auditory suppression
    • Pattern recognition suppression
    • Tactile suppression
    Neutral
    • Visual and auditory hallucinations
    • Internal hallucination
    • Visual disconnection
    • External hallucination
    • Optical sliding
    • Auditory distortion
    • Auditory hallucinations
    • Autonomous entities
    • Environmental cubism
    • Environmental orbism
    • External hallucinations
    • Internal hallucinations
    • Perception of decreased weight
    • Scenery slicing
    • Visual sliding

    Combinations TripSit

    Trip Reports Effect Index

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