Summary
Methylphenidate (also known as MPH, MPD, and the trade names Ritalin, Concerta, and Methylin, among others) is a classical potent stimulant substance of the phenidate class. It is the parent compound of the substituted phenidates, a family of stimulants that includes ethylphenidate, isopropylphenidate, and others. The mechanism of action involves increasing concentrations of the neurotransmitters dopamine and norepinephrine.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-20mg | 20-40mg | 40-60mg | 60mg+ |
| Insufflated | 2-10mg | 10-30mg | 30-60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 20-60 min | 30-90 min | 1-2 hrs | 1-2 hrs | 2-6 hrs | 240-0 min |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 1-2 hrs | 2-6 hrs | - |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Cross-tolerance
Effects
Positive
- Stimulation
- Increased alertness
Negative
- Teeth grinding
- Increased heart rate
- Dry mouth
- Nausea
- Pupil dilation
- Flushing of the face
- Tachycardia Paranoia
- Insomnia
- Increased perspiration
- Reduced appetite
- Increased body temperature
Positive
- Focus enhancement
- Motivation enhancement
- Cognitive euphoria
- Memory enhancement
- Wakefulness
- Analysis enhancement
- Euphoria
- Increased motivation
Negative
- Anxiety
- Emotion suppression
- Derealization
- Irritability
- Compulsive redosing
- Cognitive fatigue
- Depression
- Thought deceleration
- Time distortion
- Thought acceleration
- Ego inflation
- Thought organization
Positive
- Increased libido
Negative
- Appetite suppression
- Dehydration
- Light sensitivity
- Acuity Suppression
- Decreased Libido
- Appetite Suppression
- Orgasm Suppression
- Disinhibition
- Dulled perception