Diethylpropion - Substance Search

Summary TheDrug.Wiki

Formerly marketed for short-term (12 weeks) weight loss as Tenuate/Tepanil. EMA recommended withdrawal in 2022 due to pulmonary hypertension and valvular heart disease risk. Functions as prodrug to ethcathinone, a preferential norepinephrine releaser with weaker dopaminergic activity.

Dose Information TheDrug.Wiki

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki

ROA	Onset	Comeup	Peak	Offset	After Effects
Oral	20-60 min	30-60 min	1-3 hrs	1-2 hrs	1-3 hrs
Insufflated	5-15 min	15-30 min	1-2 hrs	1-2 hrs	1-3 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Stimulant 4.1

Moderate 4/10

Strong anxiety/jitters with moderate euphoria, mild stimulation, low focus

Stimulation / Energy ×3

5

increased energy stimulation

Euphoria / Mood Lift ×2

7

euphoria cognitive euphoria motivation enhancement

Focus / Productivity ×2

2

motivation enhancement

⚠ Anxiety / Jitters ×1

10

anxiety restlessness increased heart rate sweating

Based on reports from:

Erowid Experience Reports PsychonautWiki Diethylpropion

Tolerance

Build-up develops rapidly, often within a single session; compulsive redosing common

Reset a few days for acute tolerance

Tolerance Decay

Full tolerance 7d Half tolerance 3d Baseline ~14d

Stimulant tolerance generalizes across catecholaminergic agents and decays over days to weeks; values reflect community reports and stimulant physiology rather than controlled trials.