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    Diethylpropion Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Tenuate, Tepanil, Regenon, Amfepramone, Tenuate dospan

    Stimulant

    Summary dose.wiki

    Formerly marketed for short-term (12 weeks) weight loss as Tenuate/Tepanil. EMA recommended withdrawal in 2022 due to pulmonary hypertension and valvular heart disease risk. Functions as prodrug to ethcathinone, a preferential norepinephrine releaser with weaker dopaminergic activity.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Medical dosing is 25 mg immediate‑release three times daily (1 h before meals) or 75 mg sustained‑release once daily; usual total daily dose 75 mg. Non‑medical ranges below reflect anecdotal reports and exceed labeled daily totals—higher doses increase cardiovascular and neuropsychiatric risk. Short‑term use (≤12 weeks) is the historical recommendation. Not a recommended medical route. Values reflect anecdotal reports from user communities; powders/tablets contain insoluble excipients that irritate/damage nasal mucosa and increase cardiovascular strain. Avoid extended‑release products and do not share snorting implements. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 25-50mg 50-100mg 100-150mg 150mg+
    Insufflated 10-20mg 20-40mg 40-60mg 60mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-60 min 30-60 min 1-3 hrs 1-2 hrs 1-3 hrs 2.83-7 hrs
    Insufflated 5-15 min 15-30 min 1-2 hrs 1-2 hrs 1-3 hrs 2.33-4.75 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.1
    Moderate 4/10

    Strong anxiety/jitters with moderate euphoria, mild stimulation, low focus

    Stimulation / Energy ×3
    5
    increased energy stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    2
    motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate sweating
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Diethylpropion there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Diethylpropion (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Diethylpropion
    Unit
    mg
    Description 
    Diethylpropion
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10 · light 25-50 · common 50-100 · strong 100-150 · heavy 150+
Insufflated dose (mg): threshold 5 · light 10-20 · common 20-40 · strong 40-60 · heavy 60+

Oral duration: onset 0.33-1h · come-up 0.5-1h · peak 1-3h · offset 1-2h · total 2.83-7h · after-effects 1-3h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-2h · offset 1-2h · total 2.33-4.75h · after-effects 1-3h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 75 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 7d Half tolerance 3d Baseline ~14d

    Stimulant tolerance generalizes across catecholaminergic agents and decays over days to weeks; values reflect community reports and stimulant physiology rather than controlled trials.

    Cross-Tolerances

    Amphetamines
    50%
    Synthetic cathinones
    60%

    Effects dose.wiki

    Positive
    • Increased energy
    • Stimulation
    Negative
    • Dry mouth
    • Sweating
    • Increased heart rate
    • Insomnia
    • Pupil dilation
    • Tremor
    • Headache
    • Restlessness
    Neutral
    • Elevated blood pressure
    Positive
    • Motivation enhancement
    • Euphoria
    • Cognitive euphoria
    • Anxiety suppression
    Negative
    • Anxiety
    • Irritability
    • Compulsive redosing
    Neutral
    • Increased focus
    • Talkativeness
    • Time distortion
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    • Double vision
    Neutral
    • Dulled perception

    Combinations

    Cross-Check Diethylpropion with another substance

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
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    Diethylpropion's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki