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    Diethylpropion Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Tenuate, Tepanil, Regenon, Amfepramone, Tenuate dospan

    Stimulant

    Summary TheDrug.Wiki

    Formerly marketed for short-term (12 weeks) weight loss as Tenuate/Tepanil. EMA recommended withdrawal in 2022 due to pulmonary hypertension and valvular heart disease risk. Functions as prodrug to ethcathinone, a preferential norepinephrine releaser with weaker dopaminergic activity.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 25-50mg 50-100mg 100-150mg 150mg+
    Insufflated 10-20mg 20-40mg 40-60mg 60mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 1-3 hrs 1-2 hrs 1-3 hrs 4-6 hrs
    Insufflated - 1-3 hrs 1-2 hrs 1-3 hrs 4-6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.1
    Moderate 4/10

    Strong anxiety/jitters with moderate euphoria, mild stimulation, low focus

    Stimulation / Energy ×3
    5
    increased energy stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    2
    motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Diethylpropion
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 7d Half tolerance 3d Baseline ~14d

    Stimulant tolerance generalizes across catecholaminergic agents and decays over days to weeks; values reflect community reports and stimulant physiology rather than controlled trials.

    Cross-Tolerances

    Amphetamines
    50%
    Synthetic cathinones
    60%

    Effects TheDrug.Wiki

    Positive
    • Increased energy
    • Stimulation
    Negative
    • Dry mouth
    • Sweating
    • Increased heart rate
    • Insomnia
    • Pupil dilation
    • Tremor
    • Headache
    • Restlessness
    Neutral
    • Elevated blood pressure
    Positive
    • Motivation enhancement
    • Euphoria
    • Cognitive euphoria
    • Anxiety suppression
    Negative
    • Anxiety
    • Irritability
    • Compulsive redosing
    Neutral
    • Increased focus
    • Talkativeness
    • Time distortion
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    • Double vision
    Neutral
    • Dulled perception

    Combinations TripSit

    Cross-Check Diethylpropion with another substance

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
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    Diethylpropion's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki