Dimenhydrinate
Aliases: Dime, Drama, Drams, Gravol, Dimate, dramamine
Categories
Summary
Dimenhydrinate is commonly sold as Dramamine or Gravol for motion sickness treatment. It dissociates into diphenhydramine (53-55.5% by weight) and 8-chlorotheophylline in the body, with roughly half the potency of pure diphenhydramine. At recreational doses, it causes severe delirium, realistic hallucinations, profound confusion, and anticholinergic toxicity. The experience is typically described as highly dysphoric and unpleasant. Overdose can cause myocardial infarction, serious arrhythmias, coma, and death.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-250mg | 250mg-400mg | 400mg-600mg | 600mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-60 min | 30-60 min | 2-4 hrs | 2-4 hrs | 24 hrs | 300-0 min |
Tolerance
Build-up
varies by mechanism; therapeutic tolerance may develop over weeks of regular use
Reset
typically days to weeks after discontinuation
Effects
Positive
- Muscle relaxation
- Appetite Stimulation
- Nausea suppression
Negative
- Dry mouth
- Increased heart rate
- Muscle cramps
- Nausea
- Tremors
- Sedation
- Difficulty urinating
Positive
- Wakefulness
Negative
- Delirium
- Confusion
- Dysphoria
- Anxiety
- Paranoia
- Memory suppression
- Analysis suppression
- Motor control loss
- Dream-Like-Experiences
Positive
Negative
- Blurred vision
- Blurred Vision
- External hallucinations
- Internal hallucinations
- Visual and audio distortions
- Dulled perception
- Perception of Bodily Heaviness
- External Hallucination
- Auditory Hallucination
- External hallucination