Summary
The (S)-enantiomer is approximately 40 times more potent at the NMDA receptor than the (R)-enantiomer; street material is racemic. Effective oral doses typically range 50-100 mg, though sensitive individuals report psychoactivity from 10 mg and dissociative holes above 150 mg. Vaporizing requires approximately 20% of an oral dose but increases lung irritation and overdose risk. The subjective profile combines MXE-like dissociation with stimulant effects. Profound anterograde amnesia and catatonia are common at strong doses.
Perspectives
“Playing exclusively in the shallow end, this was a good introduction to the world of dissociatives.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 70-85mg | 85-110mg | 110-150mg | >150mg+ |
| Vaporized / Smoked | 20mg | 20-40mg | 40-55mg | 55mg+ |
| Rectal | 10-20mg | 20-40mg | 40-80mg | 80mg+ |
| Oral | 40-65mg | 65-100mg | 100-130mg | 130mg+ |
| Smoked | 20mg | 20-40mg | 40-55mg | 55mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral / Sublingual | 15-30 min | 1.0-3.0 hrs | 2.0-3.0 hrs | 4.0-24.0 hrs | 2.0-5.0 hrs |
| Insufflated | 4-15 min | 1.0-3.0 hrs | 2.0-3.0 hrs | 4.0-24.0 hrs | 4.0-6.0 hrs |
| Vaporized / Smoked | 1 min | 1.0-3.0 hrs | 2.0-3.0 hrs | 4.0-24.0 hrs | 4.0-6.0 hrs |
| Rectal | 10-19 min | 1.0-3.0 hrs | 2.0-3.0 hrs | 4.0-24.0 hrs | 4.0-6.0 hrs |
| Oral | 12-30 min | - | - | 4.0-24.0 hrs | 4.0-6.0 hrs |
| Smoked | 0 min | 0.5-2.0 hrs | 18-42 min | 2.0-5.0 hrs | 4.0-6.0 hrs |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Cross-tolerance
Effects
Positive
- Stimulation
- Physical euphoria
- Spontaneous tactile sensations
- Pain relief
Negative
- Increased heart rate
- Nausea
- Numbness
- Loss of balance
- Tactile disconnection
- Physical disconnection
Positive
- Cognitive euphoria
- Anxiety suppression
- Conceptual thinking
- Analysis enhancement
Negative
- Motor control loss
- Depersonalization
- Derealization
- Memory suppression
- Amnesia
- Compulsive redosing
- Dizziness
- Information processing suppression
- Thought deceleration
- Dissociation
- Time distortion
- Consciousness disconnection
- Perspective alterations
- Perspective distortions
- Physical autonomy
Positive
- Perception of bodily lightness
- Visual geometry
- Auditory enhancement
Negative
- Tactile suppression
- Acuity suppression
- Auditory suppression
- Disinhibition
- Double vision
- Frame rate suppression
- Pattern recognition suppression
- Internal hallucinations
- Visual disconnection
- Auditory distortion
- Auditory hallucinations
- Autonomous entities
- Environmental cubism
- Environmental orbism
- Perception of decreased weight
- Scenery slicing