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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    DOEF

    Aliases: Dimethoxyfluoroethylamphetamine

    Summary TheDrug.Wiki

    Extremely limited human data exists for DOEF beyond Shulgin's PiHKAL entry. Identity verification is essential as DOEF has been mis-sold as DOI or other DOx compounds. Use precise milligram scales and reagent testing for harm reduction.

    Perspectives

    “Somewhere between the first and second hour, I grew into a world that was slightly unworldly. Why? That is hard to say, as there was no appreciable visual component. I just knew that the place I was in was not completely familiar, and it was not necessarily friendly. But it was fascinating, and the music around me was magical. Time was moving slowly. I had to drive across the bay at about ten hours into this, and I was comfortable. That evening I slept well, but my dreams were pointless.”

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 30-90 min 1-3 hrs 3-6 hrs 4-6 hrs 2-4 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.8
    Moderate 4/10

    Strong body load with moderate headspace, mild auditory effects, low visuals

    Visual Intensity ×3
    2
    drifting
    Headspace Depth ×3
    6
    thought connectivity emotion enhancement time distortion
    Auditory Effects ×1
    4
    music enhancement
    Body Load / Somatic Effects ×1
    8
    vasoconstriction nausea teeth grinding increased heart rate
    Stimulant 4.6
    Moderate+ 5/10

    Strong anxiety/jitters and euphoria with mild stimulation, low focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    9
    physical euphoria cognitive euphoria euphoria
    Focus / Productivity ×2
    2
    analysis enhancement
    Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 5d Baseline ~14d

    Tolerance patterns are inferred from classical serotonergic psychedelics (rapidly acquired after one dose; substantial decay within 5–7 days; near-baseline by ~2 weeks). No DOEF-specific human pharmacology; interindividual variability can be large.

    Cross-Tolerances

    LSD
    60%
    mescaline
    50%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Increased heart rate
    • Vasoconstriction
    • Pupil dilation
    • Increased perspiration
    • Nausea
    • Teeth grinding
    • Insomnia
    Neutral
    • Decreased appetite
    Positive
    • Cognitive Euphoria
    • Analysis Enhancement
    • Thought Connectivity
    • Mindfulness
    • Emotion Enhancement
    • Wakefulness
    • Euphoria
    Negative
    • Anxiety
    Neutral
    • Time Distortion
    • Time distortion
    Positive
    • Music Enhancement
    • Bodily Control Enhancement
    • Increased music appreciation
    • Tactile enhancement
    • Increased libido
    Negative
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    Neutral
    • Tactile intensification
    • Drifting

    Combinations TripSit

    PiHKAL / TiHKAL Shulgin

    PiHKAL #65: DOEF

    “Somewhere between the first and second hour, I grew into a world that was slightly unworldly. Why? That is hard to say, as there was no appreciable visual component. I just knew that the place I was in was not completely familiar, and it was not necessarily friendly. But it was fascinating, and the music around me was magical. Time was moving slowly. I had to drive across the bay at about ten hours into this, and I was comfortable. That evening I slept well, but my dreams were pointless.”

    β€” Alexander Shulgin, PiHKAL (with 2.2 mg)

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