DOET
Aliases: Doe, Dmea, Hecate
Summary
Extremely long duration and very slow onset can lead to inadvertent redosing. Vasoconstriction, tachycardia, and anxiety reported above 5 mg. Clinical trials in the 1960s studied sub-hallucinogenic doses (0.75-4 mg) as a potential 'psychic energizer' before development was terminated.
Perspectives
“This was a very gentle, relaxing level, but there were no psychedelic effects that were apparent. Easy, and relaxed, and I am in no way intoxicated or turned on. But I was in the throes of my menstrual period, and the cramps (and the accompanying irritability) were completely knocked out. Perhaps this is why I felt so relaxed and at peace.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-4mg | 4-6mg | 6-10mg | 10mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-3 hrs | 1-2 hrs | 3-5 hrs | 10-14 hrs | 15-24 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild visuals with low body load and headspace
Strong anxiety/jitters with moderate euphoria, low stimulation
Tolerance
Tolerance Decay
Tolerance to 5‑HT2A agonists develops quickly and decays over 1–2 weeks; cross‑tolerance across serotonergic psychedelics is expected. Data are inferred from human/animal LSD literature and community experience; specific DOET kinetics are sparsely characterized.
Cross-Tolerances
Effects
- Stimulation
- Mental/physical stimulation
- Pupil dilation
- Restlessness
- Sweating/chills
- Muscle tension
- Insomnia
- Increased heart rate
- Body image awareness
- Decreased appetite
- Cognitive euphoria
- Enhanced self-awareness
- Emotional enhancement
- Euphoria
- Empathy
- Insight
- Anxiety
- Confusion
- Time distortion
- Talkativeness
- Change in perception
- Ego softening
- Color enhancement
- Increased tactile sensation
- Brightened colour
- Enhanced tactile sensation
- Increased music appreciation
- Light sensitivity
- Disinhibition
- Closed-eye visuals
- Open-eye visual distortions
- Closed/Open eye visuals
Combinations
PiHKAL / TiHKAL
“This was a very gentle, relaxing level, but there were no psychedelic effects that were apparent. Easy, and relaxed, and I am in no way intoxicated or turned on. But I was in the throes of my menstrual period, and the cramps (and the accompanying irritability) were completely knocked out. Perhaps this is why I felt so relaxed and at peace.”