biostats: male, 36, 150#, hyper metabolism. set : great headspace; highly active day(s); flurry of activity getting packed and ready for a large gathering. setting : On road to and at a 3 day musical gathering in the mountains. Weather was warm and rainy.
DOET
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: Doe, Dmea, Hecate
Summary
Extremely long duration and very slow onset can lead to inadvertent redosing. Vasoconstriction, tachycardia, and anxiety reported above 5 mg. Clinical trials in the 1960s studied sub-hallucinogenic doses (0.75-4 mg) as a potential 'psychic energizer' before development was terminated.
Perspectives
“This was a very gentle, relaxing level, but there were no psychedelic effects that were apparent. Easy, and relaxed, and I am in no way intoxicated or turned on. But I was in the throes of my menstrual period, and the cramps (and the accompanying irritability) were completely knocked out. Perhaps this is why I felt so relaxed and at peace.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-4mg | 4-6mg | 6-10mg | 10mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-3 hrs | 1-2 hrs | 3-5 hrs | 10-14 hrs | 12-30 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.1
Light+
3/10
Mild visuals with low body load and headspace
Visual Intensity
×3
4
color enhancement
open-eye visual distortions
brightened colour
Headspace Depth
×3
2
time distortion
confusion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
3
muscle tension
increased heart rate
Stimulant
2.6
Light+
3/10
Strong anxiety/jitters with moderate euphoria, low stimulation
Stimulation / Energy
×3
3
stimulation
Euphoria / Mood Lift
×2
6
cognitive euphoria
euphoria
Focus / Productivity
×2
0
Anxiety / Jitters
×1
10
anxiety
restlessness
increased heart rate
muscle tension
Based on reports from:
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Name
DOET
Unit
mg
Description
DOET Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 1 · light 2-4 · common 4-6 · strong 6-10 · heavy 10+ Oral duration: onset 1-3h · come-up 1-2h · peak 3-5h · offset 10-14h · total 12-30h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
5d
Baseline
~21d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance to 5‑HT2A agonists develops quickly and decays over 1–2 weeks; cross‑tolerance across serotonergic psychedelics is expected. Data are inferred from human/animal LSD literature and community experience; specific DOET kinetics are sparsely characterized.
Cross-Tolerances
Effects
Positive
- Stimulation
- Mental/physical stimulation
Negative
- Pupil dilation
- Restlessness
- Sweating/chills
- Muscle tension
- Insomnia
- Increased heart rate
- Body image awareness
- Decreased appetite
Positive
- Cognitive euphoria
- Enhanced self-awareness
- Emotional enhancement
- Euphoria
- Empathy
- Insight
Negative
- Anxiety
- Confusion
- Time distortion
- Talkativeness
- Change in perception
- Ego softening
Positive
- Color enhancement
- Increased tactile sensation
- Brightened colour
- Enhanced tactile sensation
- Increased music appreciation
Negative
- Light sensitivity
- Disinhibition
- Closed-eye visuals
- Open-eye visual distortions
- Closed/Open eye visuals
Combinations
Cross-Check DOET with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 neutral visit
Bluelight 1 thread 1 neutral visit
At a festival of sorts (imagine a festival in Royston Vasey - a local festival for local people!) and around the 7pm mark it's time to start the proceedings with 2.5mg of DOET down the hatch. Onset was very smooth over 2 hours, with all the same telltale alerts as DOM, only not as in your face.
PiHKAL / TiHKAL
PiHKAL #66: DOET
“This was a very gentle, relaxing level, but there were no psychedelic effects that were apparent. Easy, and relaxed, and I am in no way intoxicated or turned on. But I was in the throes of my menstrual period, and the cramps (and the accompanying irritability) were completely knocked out. Perhaps this is why I felt so relaxed and at peace.”
DOET's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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