Summary
Ephenidine is a potent NMDA receptor antagonist with dissociative effects similar to ketamine but with longer duration. Heavy doses readily cause amnesia, blackouts, and loss of motor control. Start with low doses as it has the highest NMDA receptor affinity among diarylethylamines. Vaporization is suspected to be carcinogenic and requires only 20% of oral doses. Limited human pharmacokinetic data exists; approach with caution and employ harm reduction practices.
Perspectives
“Whilst this is probably my favourite member of this class, its status as a relatively unknown research chemical has deterred anything other than very occasional use.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-70mg | 70-100mg | 100-150mg | 150mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 10-30 min | 30-60 min | 1.0-3.0 hrs | 2.0-4.0 hrs | 2.0-6.0 hrs | 5.0-7.0 hrs |
| Rectal | 10-19 min | 19-40 min | 1.0-3.0 hrs | 2.0-4.0 hrs | 2.0-6.0 hrs | 3.0-6.0 hrs |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Cross-tolerance
Effects
Positive
- Pain relief
- Spontaneous tactile sensations
- Stimulation
- Physical euphoria
Negative
- Nystagmus
- Increased heart rate
- Numbness
- Loss of balance
- Tactile disconnection
- Physical disconnection
Positive
- Cognitive euphoria
- Conceptual thinking
- Analysis enhancement
- Anxiety suppression
- Motivation enhancement
- Unity and interconnectedness
Negative
- Depersonalization
- Derealization
- Motor control loss
- Memory suppression
- Analysis suppression
- Amnesia
- Compulsive redosing
- Information processing suppression
- Thought deceleration
- Dissociation
- Time distortion
- Consciousness disconnection
- Ego inflation
- Perspective alterations
- Perspective distortions
- Physical autonomy
- Thought acceleration
Positive
- Perception of bodily lightness
- Music enhancement
- Auditory enhancement
Negative
- Tactile suppression
- Double vision
- Pattern recognition suppression
- Spatial disorientation
- Acuity suppression
- Auditory suppression
- Disinhibition
- Frame rate suppression
- Visual drifting
- Visual disconnection
- Spontaneous physical sensations
- Auditory distortion
- Auditory hallucinations
- Autonomous entities
- Drifting
- Internal hallucinations
- Perception of decreased weight
- Scenery slicing