Pleasant, Then Unpleasant... A Likely Underdose First Ephenidine Trial 8-7-2019 by Xorkoth 12:50pm (T+0:00) - Ingested 60mg orally of a fine white powder. It tastes rather pleasant actually, I can't quite put my finger on what it's like, but it's not bitter.
Ephenidine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Aliases: Epe, Nedpa
Summary
Ephenidine is a potent NMDA receptor antagonist with dissociative effects similar to ketamine but with longer duration. Heavy doses readily cause amnesia, blackouts, and loss of motor control. Start with low doses as it has the highest NMDA receptor affinity among diarylethylamines.
Perspectives
“I love this stuff. It is like dissociative 2C-B or LSD. It is easily the most psychedelic and most visual dissociative I have taken, and I love it! The visuals are spectacular, colorful, beautiful, complex and organic.”
“Whilst this is probably my favourite member of this class, its status as a relatively unknown research chemical has deterred anything other than very occasional use.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-70mg | 70-100mg | 100-150mg | 150mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 10-30 min | 30-60 min | 1-3 hrs | 2-4 hrs | 5-7 hrs |
| Rectal | 10-19 min | 19-40 min | 1-3 hrs | 2-4 hrs | 3-6 hrs |
Effect Profile
16 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
7.1
Strong+
7/10
Strong dissociative depth, mania, insight, and motor impairment
Dissociative Depth
×3
10
depersonalization
derealization
consciousness disconnection
tactile disconnection
physical disconnection
visual disconnection
+6 more
Mania / Compulsion
×1
10
compulsive redosing
thought acceleration
disinhibition
stimulation
Insight / Novel Thought
×2
10
conceptual thinking
analysis enhancement
perspective alterations
unity and interconnectedness
perspective distortions
Motor / Sensory Impairment
×1
10
motor control loss
tactile disconnection
physical disconnection
tactile suppression
numbness
spatial disorientation
+2 more
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
3d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Estimates reflect strong, rapid cross-tolerance typical of NMDA antagonists; values are extrapolated from dissociative literature and user reports rather than controlled human PK studies.
Cross-Tolerances
Effects
Aggregated from 16 Erowid experience reports
Positive Effects 9
Stimulation
68.8%
70%
Euphoria
56.2%
70%
Color Enhancement
50.0%
70%
Music Enhancement
50.0%
70%
Focus Enhancement
43.8%
70%
Empathy
37.5%
70%
Body High
31.2%
70%
Tactile Enhancement
25.0%
70%
Pain Relief
18.8%
70%
Adverse Effects 5
Anxiety
50.0%
70%
Confusion
43.8%
70%
Nausea
31.2%
70%
Motor Impairment
31.2%
70%
Memory Suppression
18.8%
70%
Combinations
Cross-Check Ephenidine with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 5 reports 2 positive 2 neutral 1 cautionary visit
So to begin, I have been very ill for quite some time due to a very high dose benzodiazepine addiction and am in a very slow and painful withdrawal period. As is quite well known, dissociatives help ease the withdrawal symptoms, and due to lack of access to 'safer' chemicals, I chose Ephenidine to ease my pain, and hav...
So a little background, me and my Girlfriend (I'll call her G from now on) have lived together for around 2 years, and both of us are inexperienced with drugs. Our experience consists of trying weed a couple of times and probably not even getting high.
Me and My Addiction to Ephenidine I had been experimenting with ketamine for my first time, absolutely loving the high and going deeper and deeper into the hole over the space of a couple of weeks, our town went DRY! So I ordered 10g of ephenidine from a reputable RC vendor.
[Erowid Note: The doses described in this report are potentially life threatening. The amount taken is beyond a heavy dose and could pose serious health risks or result in unwanted, extreme effects. Doses such as this have been known to cause hospitalizations and/or deaths.
Bluelight 2 threads 1 positive 1 neutral visit
Pleasant, Then Unpleasant... A Likely Underdose First Ephenidine Trial 8-7-2019 by Xorkoth 12:50pm (T+0:00) - Ingested 60mg orally of a fine white powder. It tastes rather pleasant actually, I can't quite put my finger on what it's like, but it's not bitter.
Age: 26 Weight: 130 lbs Dosage: 200 mg oral in gel cap Setting: The house where I grew up Preface: Isopropylphenidine (aka NPDPA, Isophenidine) (different from isopropylpheniDATE/IPPH, the stimulant methylphenidate analogue) is a dissociative in the Diarylethylamine class, similar to Diphenidine and Ephenidine.
Bluelight Reference Guide
☛ Official ☚ The Big & Dandy Ephenidine (N-ethyl-1,2-diphenylethylamine) Thread
Welcome to the Big & Dandy Ephenidine Thread iupac = N-ethyl-1,2-diphenylethylamine (NEDPA) Introduction Ephenidine is a dissociative anesthetic of the diarylethylamine class, which emerged after the arylcyclohexylamine ban in the UK.
Read full thread on Bluelight →
Ephenidine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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