IC-26
Aliases: Win 1161-3
Summary
Methiodone replaces methadone's ketone with a sulfone bioisostere, preserving ฮผ-agonism but with variable potency reported at approximately 0.5-1.0ร methadone. Users describe a slow, maintenance-like warmth rather than sharp euphoria. The caustic powder is best administered in oral capsules or dilute solutions.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-35mg | 35mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 1-3 hrs | 2-6 hrs | 6-12 hrs | 9.5-23 hrs |
| Rectal | 15-45 min | 30 min | 2-6 hrs | 6-12 hrs | 8.8-19.2 hrs |
| Insufflated (Very Caustic; Discouraged) | 10-30 min | 20 min | 2-6 hrs | 6-12 hrs | 8.5-18.8 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
5.4
Moderate+
5/10
Moderate euphoria and itching/nausea with mild sedation and pain relief
Euphoria / Warmth
×3
7
physical euphoria
euphoria
mood lift
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
5
sedation
relaxation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
7d
Half tolerance
10d
Baseline
~21d
Estimates reflect typical opioid tolerance patterns and user reports: daily use for ~7 days reaches high tolerance; partial reversal over 10โ14 days; near-baseline by 3โ4 weeks. Data quality is low and based on analogy to methadone plus community reports.
Cross-Tolerances
Effects
Positive
- Physical Euphoria
- Pain Relief
- Cough Suppression
- Reduced Opioid Cravings
Negative
- Respiratory Depression
- Nausea
- Sedation
- Itchiness
- Pupil Constriction
- Difficulty Urinating
Positive
- Anxiety Suppression
- Relaxation
- Motivation Enhancement
- Euphoria
- Mood lift
- Reduced anxiety
Negative
- Constipation
- Dream Suppression
- Anxiety
- Time distortion
Positive
- Increased music appreciation
- Color enhancement
- Tactile enhancement
- Increased libido
Negative
- Appetite Suppression
- Light sensitivity
- Dehydration
- Appetite suppression
- Disinhibition
- Dulled perception
Combinations
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