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    Disclaimer
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    โš  Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    IC-26 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical

    Aliases: Win 1161-3

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Methiodone replaces methadone's ketone with a sulfone bioisostere, preserving ฮผ-agonism but with variable potency reported at approximately 0.5-1.0ร— methadone. Users describe a slow, maintenance-like warmth rather than sharp euphoria. The caustic powder is best administered in oral capsules or dilute solutions.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-20mg 20-35mg 35mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 0.5-2 hrs 1-3 hrs 2-6 hrs 6-12 hrs 24 hrs 6-24 hrs
    Rectal 15-45 min 30 min 2-6 hrs 6-12 hrs 24 hrs 6-24 hrs
    Insufflated (Very Caustic; Discouraged) 10-30 min 20 min 2-6 hrs 6-12 hrs 24 hrs 6-24 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 5.4
    Moderate+ 5/10

    Moderate euphoria and itching/nausea with mild sedation and pain relief

    Euphoria / Warmth ×3
    7
    physical euphoria euphoria mood lift
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    5
    sedation relaxation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki IC-26
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7โ€“14 days for partial reset; full reset may take weeks โ€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 7d Half tolerance 10d Baseline ~35d

    Estimates reflect typical opioid tolerance patterns and user reports: daily use for ~7 days reaches high tolerance; partial reversal over 10โ€“14 days; near-baseline by 3โ€“4 weeks. Data quality is low and based on analogy to methadone plus community reports.

    Cross-Tolerances

    Methadone
    100%
    Other full ฮผ-agonists (e.g., morphine, oxycodone)
    70%
    Kratom/7-OH-mitragynine
    50%

    Effects TheDrug.Wiki

    Positive
    • Physical Euphoria
    • Pain Relief
    • Cough Suppression
    • Reduced Opioid Cravings
    Negative
    • Respiratory Depression
    • Nausea
    Neutral
    • Sedation
    • Itchiness
    • Pupil Constriction
    • Difficulty Urinating
    Positive
    • Anxiety Suppression
    • Relaxation
    • Motivation Enhancement
    • Euphoria
    • Mood lift
    • Reduced anxiety
    Negative
    • Constipation
    • Dream Suppression
    • Anxiety
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Color enhancement
    • Tactile enhancement
    • Increased libido
    Negative
    • Appetite Suppression
    • Light sensitivity
    • Dehydration
    • Appetite suppression
    • Disinhibition
    Neutral
    • Dulled perception

    Combinations TripSit

    Cross-Check IC-26 with another substance

    IC-26's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– TripSit ๐Ÿ“– PsychonautWiki