IC-26
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Research-chemical
Aliases: Win 1161-3
Summary
Methiodone replaces methadone's ketone with a sulfone bioisostere, preserving ฮผ-agonism but with variable potency reported at approximately 0.5-1.0ร methadone. Users describe a slow, maintenance-like warmth rather than sharp euphoria. The caustic powder is best administered in oral capsules or dilute solutions.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-35mg | 35mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 1-3 hrs | 2-6 hrs | 6-12 hrs | 6-24 hrs |
| Rectal | 15-45 min | 30 min | 2-6 hrs | 6-12 hrs | 6-24 hrs |
| Insufflated (Very Caustic; Discouraged) | 10-30 min | 20 min | 2-6 hrs | 6-12 hrs | 6-24 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate euphoria and itching/nausea with mild sedation and pain relief
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IC-26 Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 5-10 ยท light 5-10 ยท common 10-20 ยท strong 20-35 ยท heavy 35+ Rectal dose (mg): threshold 3-8 Insufflated (Very Caustic; Discouraged) dose (mg): threshold 5-15 Oral duration: onset 0.5-2h ยท come-up 1-3h ยท peak 2-6h ยท offset 6-12h ยท total 6-24h ยท after-effects 24h Rectal duration: onset 15-45m ยท come-up 30m ยท peak 2-6h ยท offset 6-12h ยท total 6-24h ยท after-effects 24h Insufflated (Very Caustic; Discouraged) duration: onset 10-30m ยท come-up 20m ยท peak 2-6h ยท offset 6-12h ยท total 6-24h ยท after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Estimates reflect typical opioid tolerance patterns and user reports: daily use for ~7 days reaches high tolerance; partial reversal over 10โ14 days; near-baseline by 3โ4 weeks. Data quality is low and based on analogy to methadone plus community reports.
Cross-Tolerances
Effects
- Physical Euphoria
- Pain Relief
- Cough Suppression
- Reduced Opioid Cravings
- Respiratory Depression
- Nausea
- Sedation
- Itchiness
- Pupil Constriction
- Difficulty Urinating
- Anxiety Suppression
- Relaxation
- Motivation Enhancement
- Euphoria
- Mood lift
- Reduced anxiety
- Constipation
- Dream Suppression
- Anxiety
- Time distortion
- Increased music appreciation
- Color enhancement
- Tactile enhancement
- Increased libido
- Appetite Suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Dulled perception
Combinations
Cross-Check IC-26 with another substanceHelpful Links
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