IC-26
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- classified Research-chemical
Aliases: Win 1161-3
Summary
Methiodone replaces methadone's ketone with a sulfone bioisostere, preserving ฮผ-agonism but with variable potency reported at approximately 0.5-1.0ร methadone. Users describe a slow, maintenance-like warmth rather than sharp euphoria. The caustic powder is best administered in oral capsules or dilute solutions.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-35mg | 35mg+ |
Sources
Oral
Dose ladder — TripSitOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 1-3 hrs | 2-6 hrs | 6-12 hrs | 6-24 hrs |
| Rectal | 15-45 min | 30 min | 2-6 hrs | 6-12 hrs | 6-24 hrs |
| Insufflated (Very Caustic; Discouraged) | 10-30 min | 20 min | 2-6 hrs | 6-12 hrs | 6-24 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate euphoria with moderate itching/nausea, mild sedation and pain relief
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin ยท National Harm Reduction Coalition ยท WHO: opioid overdose ยท Merrall et al. 2010 ยท Binswanger et al. 2007 ยท Strang et al. 2003 ยท FDA 2019: gabapentinoids and breathing
Cross-Tolerances
Effects
Effect glossary — · full glossary
Combinations
Cross-Check IC-26 with another substanceHelpful Links
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IC-26 Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 5-10 ยท light 5-10 ยท common 10-20 ยท strong 20-35 ยท heavy 35+ Oral duration: onset 0.5-2h ยท come-up 1-3h ยท peak 2-6h ยท offset 6-12h ยท total 6-24h ยท after-effects 24h Rectal duration: onset 15-45m ยท come-up 30m ยท peak 2-6h ยท offset 6-12h ยท total 6-24h ยท after-effects 24h Insufflated (Very Caustic; Discouraged) duration: onset 10-30m ยท come-up 20m ยท peak 2-6h ยท offset 6-12h ยท total 6-24h ยท after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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