Summary
Methiodone replaces methadone's ketone with a sulfone bioisostere, preserving ฮผ-agonism but with variable potency reported at approximately 0.5-1.0ร methadone. Users describe a slow, maintenance-like warmth rather than sharp euphoria. The caustic powder is best administered in oral capsules or dilute solutions. Accumulates over successive days; wait at least 12 hours before redosing. QT prolongation risk is assumed comparable to methadone; ECG monitoring is advised for chronic use.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-35mg | 35mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 1-3 hrs | 2-6 hrs | 6-12 hrs | 24 hrs | 360-0 min |
| Rectal | 15-45 min | 30 min | 2-6 hrs | 6-12 hrs | 24 hrs | 360-0 min |
| Insufflated (Very Caustic; Discouraged) | 10-30 min | 20 min | 2-6 hrs | 6-12 hrs | 24 hrs | 360-0 min |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Effects
Positive
- Physical Euphoria
- Pain Relief
- Cough Suppression
- Reduced Opioid Cravings
Negative
- Respiratory Depression
- Nausea
- Sedation
- Itchiness
- Pupil Constriction
- Difficulty Urinating
Positive
- Anxiety Suppression
- Relaxation
- Motivation Enhancement
- Euphoria
- Mood lift
- Reduced anxiety
Negative
- Constipation
- Dream Suppression
- Anxiety
- Time distortion
Positive
- Increased music appreciation
- Color enhancement
- Tactile enhancement
- Increased libido
Negative
- Appetite Suppression
- Light sensitivity
- Dehydration
- Appetite suppression
- Disinhibition
- Dulled perception