I will skip how I got onto MMT (Methadone Maintanence Treatment) since that isn't the point here. The program I got on had me go to 3 day a week 3 hour a day group meetings with a counselor. Plus I got my methadone which I started at 30mg and went to 175mg. I have since come down to 145mg.
Methadone
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 6 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 6 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Aliases: Mud, Dolls, Metho, Juice, Wafers
Summary
Methadone (sold under trade names such as Dolophine and Methadose) is a synthetic opioid analgesic used for the treatment of moderate to severe pain and for the treatment of opioid addiction. It is commonly used to treat and manage the symptoms of opioid addiction. The subjective effects are similar to those of other synthetic opioids such as fentanyl, however, most users note a significantly stronger euphoria.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 3-5mg | 5-15mg | 15-30mg | 30mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 20-90 min | 2-4 hrs | 4-6 hrs | 4-6 hrs |
| Intravenous | 1-5 min | 5-15 min | 2-4 hrs | 12-36 hrs |
Opioid MME Calculator
⚠ Citation & Disclaimer:
Conversion factors sourced from the
NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025),
the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain,
and the MDCalc MME Calculator.
These are approximate equianalgesic ratios for educational reference only.
Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration.
This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.
mg
2.1
mg
Methadone
≈
—
mg
Morphine
| Substance | Equivalent Dose | MME Factor |
|---|
⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
159 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 149 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
8.3
Intense
8/10
Strong euphoria, pain relief, itching/nausea, and sedation
Euphoria / Warmth
×3
10
physical euphoria
euphoria
mood lift
Analgesia
×2
10
pain relief
analgesia
Sedation / Relaxation
×1
8
sedation
relaxation
Itching / Nausea
×1
10
nausea
constipation
dry mouth
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
7d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance to sedative/respiratory effects builds with daily use over 1–2 weeks but decays slowly; after ≥3–4 missed doses, clinically significant loss of tolerance can occur and resumption doses should be reduced and retitrated.
Cross-Tolerances
Effects
Aggregated from 149 Erowid and 10 Bluelight experience reports
Positive Effects 26
Contentment
50.0%
79%
Euphoria
34.0%
91%
Sedation
29.5%
86%
Anxiety Suppression
27.7%
85%
Empathy
26.4%
90%
Stimulation
23.9%
90%
Heaviness
20.0%
85%
Muscle Relaxation
20.0%
85%
Emotional Openness
20.0%
80%
Tactile Enhancement
13.4%
70%
Body High
11.3%
88%
Music Enhancement
10.1%
70%
Visual Trails
10.0%
70%
Joy
10.0%
80%
Scene Replacement
10.0%
85%
Melting/flowing
10.0%
80%
Love
10.0%
85%
Introspection
10.0%
75%
Physical Energy Burst
10.0%
70%
Tingling
10.0%
90%
Adverse Effects 21
Nausea
29.0%
85%
Confusion
20.7%
80%
Ataxia
20.0%
82%
Dizziness
20.0%
85%
Blurred Vision
10.0%
90%
Body Temperature Change
10.0%
75%
Depersonalization
10.0%
80%
Temporal Disorientation
10.0%
75%
Vomiting
10.0%
90%
Panic
10.0%
80%
Fear
10.0%
85%
Sweating
8.7%
70%
Memory Suppression
6.7%
70%
Motor Impairment
4.7%
70%
Increased Heart Rate
4.0%
70%
Headache
3.4%
70%
Pupil Dilation
3.4%
70%
Seizure
3.4%
70%
Appetite Suppression
3.2%
80%
Psychosis
2.7%
70%
Combinations
Cross-Check Methadone with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 3 positive 3 neutral 2 cautionary visit
I began abusing drugs when I was 16, and by the time I graduated high school, I was an addict. I soon began experimenting with opiates (Percocet, etc.) and eventually found Oxycontin and then later moved on to heroin. In the end of my addiction, I was using heroin intravenously and was homeless.
Hello everyone. I am an 19 year old guy from a small town in Ontario. I was always a 'good' kid growing up, I got good grades, I was respected by my family and friends, never got into much trouble. I was introduced to drugs at age 12. I knew alot about most drugs and I hadn't even used yet.
Where to begin, I guess the best place to start is the beginning. In the beginning I was normal, well, as normal as any freshman college girl from a small town in the near college town (the city).
INTRODUCTION: My true love kicked methadone (and opiates for good) after a couple of years being a junkie. I thought it might be helpful to share his/our story of how we did it. I say we because he could do this alone.
This is meant as a documentation of how my life was directly affected by methadone/methadose. I am still not sure whether or not my decisions were the right ones but I do know that my life has been changed for the better due to the effects of methadone and due to how it changed my perception of my surroundings even whe...
I'm in no ways a regular user of opiates, opioids or any other substances, besides alcohol - I do not enjoy cannabis. I indulge in alcohol 1-2 times a week, usually by drinking the equivalent of 16-20 bottles of beer and buzzing hard as a result.
This experience took place in 1994, at that time I had had a poly substance abuse problem for 5 years. Although I indulged vigorously in various psychedelics and stimulants I had a fairly substantial heroin habit. I had maintained my addiction to heroin for 3 years with no major negative drawbacks.
Bluelight 6 threads 6 neutral visit
I've done a long lists of various opioids, but one important one was still missing, methadone. I aquired 3 pills of 20mg and 1 pill of 10mg from a friend and fellow bluelighter by trading some coke for his methadone.
So at the time of the experience I was 16. It was a weekend and I was headed to my friends house to do the usual. We're gonna call him Kyle. We would sit in his room and get baked out of our minds (and high on plenty of other things), watch trailer park boys, go out to eat, or hang out with girls.
I guess I should start with the basics. I was spending the evening with my friend S and his girlfriend J in S's motel room. J (19-years-old, 6'1", 165 lbs) S (16-years-old, 5'3", 105 lbs) Me(19-years-old, 5'7", 118 lbs) Yesterday the three of us were hoping to find some speed because J had just got some money early in...
Through My Other Mouth A Tale of Light, and a Dark, Dark, Tunnel Brought to You by Znegative So I was sitting around this Sunday morning, finishing up the last sip of my coffee, feeling lethargic as I looked hopelessly out my window.
New here just to post this. What happened: Going to make this concise and as scientific as possible to help others. I took 50 mg methadone liquid recently for my first time. I did NOT do this on purpose, as I was told the concentration was 1mg/mL but was in fact 10 mg/mL.
Methadone Trip Report 80mg (16mL) intravenous injection 10am (T=0:00) - I am dispensed my 80mg methadone dose as usual from the chemist, and since the pharmacist on duty is known to just leave one's dose on the counter and go back to business, I take the opportunity to hold in in my mouth and spit it into an empty Coke...
Pill Identifiers
13
known pill identifiers on record — view imprints, colors, shapes, and images
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Methadone's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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