Methadone (sold under trade names such as Dolophine and Methadose) is a synthetic opioid analgesic used for the treatment of moderate to severe pain and for the treatment of opioid addiction. It is commonly used to treat and manage the symptoms of opioid addiction. The subjective effects are similar to those of other synthetic opioids such as fentanyl, however, most users note a significantly stronger euphoria.
⚠ Equianalgesic dose ratios are approximations and do not account for
genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations.
Methadone conversion is especially variable at higher doses.
Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
159 reports
Scores (1–10) curated from multiple sources:
Effect keyword matching from PsychonautWiki catalog
Validated against 149 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)
Build-updevelops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
7dHalf tolerance
4dBaseline
~14d
Tolerance to sedative/respiratory effects builds with daily use over 1–2 weeks but decays slowly; after ≥3–4 missed doses, clinically significant loss of tolerance can occur and resumption doses should be reduced and retitrated.