MDPHP
Aliases: Rave, Mdpv, Nrg-1, Magic, O-2482, monkey-dust, bath_salts
Categories
Summary
MDPV is one of the most potent dopamine reuptake inhibitors known, blocking DAT with IC50 values of 4.1 nM and NET at 26 nM while having minimal serotonergic activity. This pharmacological profile makes it significantly more potent than cocaine (50-fold at DAT) and produces intense stimulation with powerful compulsive redosing. The plasma elimination half-life is approximately 80-120 minutes, though subjective effects persist 4-6 hours due to slow brain egress. Dosing accuracy below 5 mg requires a 0.001 g milligram scale or volumetric solution preparation, as eyeballing powder leads to dangerous overdoses. Acute harms include severe vasoconstriction, rhabdomyolysis, hyperthermia, and excited delirium.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 4-8mg | 8-14mg | 14-25mg | 25mg+ |
| Insufflated | 2-5mg | 5-11mg | 10-20mg | 20mg+ |
| Oral / Sublingual | 10-20mg | 20-35mg | 35mg | 35mg+ |
| Rectal | 3-8mg | 6-12mg | 10-25mg | 25mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 30-90 min | 30-60 min | 1-3 hrs | 2-4 hrs | 6-24 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 2-3 hrs | 6-24 hrs |
| Vaporized | - | 5-15 min | 30-90 min | 1-3 hrs | 6-24 hrs |
| Oral / Sublingual | 15-45 min | 30-60 min | 0.5-3 hrs | 0.5-2 hrs | 2-48 hrs |
| Vaporized / Smoked | 0-1 min | 5-15 min | 0.5-2 hrs | 30-60 min | 2-48 hrs |
| Rectal | 5-10 min | 15-30 min | 0.5-2 hrs | 30-60 min | 2-48 hrs |
Tolerance
Effects
- Stimulation
- Physical euphoria
- Increased energy
- Teeth grinding
- Vasoconstriction
- Increased heart rate
- Increased blood pressure
- Temporary erectile dysfunction
- Physical fatigue
- Temperature regulation suppression
- Dry Mouth
- Muscle Tension
- Restlessness
- Headache
- Loss of apetite
- Frequent urination
- Muscle Contractions
- Uncomfortable Stimulation
- Elevated heart rate
- Motivation enhancement
- Cognitive Euphoria
- Focus Enhancement
- Empathy, Affection and Sociability Enhancement
- Wakefulness
- Euphoria
- Alertness
- Incresed Motivation
- Mood Enhancement
- Increased mental clarity
- Compulsive redosing
- Anxiety
- Paranoia
- Thought disorganization
- Psychosis
- Cognitive impairment
- Confusion
- Delusions
- Focus intensification
- Ego inflation
- Time Distortion
- Thought Organization
- Thought Acceleration
- Increased libido
- Increased music appreciation
- Sexual Enhancement
- Disinhibition
- Appetite suppression
- Dehydration
- Light sensitivity
- Auditory Distortion
- Auditory Hallucinations
- Sexual arousal