MDPHP - Substance Search

Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

3,4-Methylenedioxypyrovalerone (also known as MDPV, and Monkey Dust) is a novel lesser-known stimulant substance of the cathinone and pyrrolidine classes. It is known to be one of the most powerful and potent stimulants. MDPV is thought to act primarily as a norepinephrine-dopamine reuptake inhibitor (NDRI).

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	4-8mg	8-14mg	14-25mg	25mg+
Insufflated	2-5mg	5-11mg	10-20mg	20mg+
Oral / Sublingual	10-20mg	20-35mg	35mg	35mg+
Rectal	3-8mg	6-12mg	10-25mg	25mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects
Oral	30-90 min	30-60 min	1-3 hrs	2-4 hrs	6-24 hrs
Insufflated	5-15 min	15-30 min	1-2 hrs	2-3 hrs	6-24 hrs
Oral / Sublingual	15-45 min	30-60 min	0.5-3 hrs	0.5-2 hrs	2-48 hrs
Vaporized / Smoked	0-1 min	5-15 min	0.5-2 hrs	30-60 min	2-48 hrs
Rectal	5-10 min	15-30 min	0.5-2 hrs	30-60 min	2-48 hrs

Effect Profile

107 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 107 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Empathogen 7.9

Intense 8/10

Strong euphoria and stimulation with moderate sensory enhancement and empathy

Empathy / Social Openness ×3

6

empathy, affection and sociability enhancement

Euphoria / Mood Elevation ×2

10

physical euphoria cognitive euphoria euphoria mood enhancement

Stimulation ×1

10

stimulation increased energy wakefulness alertness teeth grinding restlessness +1 more

Sensory Enhancement ×1

7

increased libido

Stimulant 8.8

Intense+ 9/10

Strong stimulation, euphoria, focus, and anxiety/jitters

Stimulation / Energy ×3

10

stimulation increased energy wakefulness alertness

Euphoria / Mood Lift ×2

10

physical euphoria cognitive euphoria euphoria mood enhancement motivation enhancement

Focus / Productivity ×2

10

focus enhancement motivation enhancement thought acceleration

⚠ Anxiety / Jitters ×1

10

anxiety restlessness paranoia teeth grinding increased heart rate vasoconstriction +1 more

Based on reports from:

Erowid Experience Reports PsychonautWiki MDPHP

Tolerance

Build-up develops over days to weeks of regular use

Reset 3–7 days for acute; 1–3 weeks for full reset

Tolerance Decay

Full tolerance 1d Half tolerance 4d Baseline ~10d

Strong acute tolerance within a session with rapidly diminishing euphoria; inter‑session tolerance decays over several days. Data are largely anecdotal from user reports across pyrrolidinophenones; individual variability is large.

Cross-Tolerances

synthetic cathinones (pyrrolidinophenones)

60%

amphetamines

30%

Effects Erowid

Aggregated from 107 Erowid experience reports

Positive Effects 10

Stimulation 57.0% 70%

Euphoria 55.1% 70%

Focus Enhancement 34.6% 70%

Empathy 25.2% 70%

Music Enhancement 20.6% 70%

Tactile Enhancement 17.8% 70%

Color Enhancement 12.1% 70%

Creativity Enhancement 10.3% 70%

Introspection 8.4% 70%

Body High 4.7% 70%

Adverse Effects 13

Anxiety 49.5% 70%

Increased Heart Rate 25.2% 70%

Confusion 19.6% 70%

Jaw Clenching 13.1% 70%

Headache 12.1% 70%

Psychosis 11.2% 70%

Nausea 11.2% 70%

Pupil Dilation 10.3% 70%

Muscle Tension 9.3% 70%

Sweating 8.4% 70%

Motor Impairment 6.5% 70%

Memory Suppression 2.8% 70%

Appetite Suppression 2.8% 70%

Combinations TripSit

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Helpful Links

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