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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Methoxetamine

    Aliases: Mxe, Mexxy, M-ket, Roflcopter, 3-meo-2'oxo-pce

    Categories

    Dissociative Research-chemical
    Methoxetamine structure

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Methoxetamine exhibits pharmacokinetics similar to ketamine with an elimination half-life of 3-6 hours and active metabolites (O-desmethyl and N-desethyl) that may prolong subjective effects. Clinical reports document reversible cerebellar ataxia, sensorimotor gating disruption, and bladder toxicity resembling ketamine cystitis. The substance is four times more potent than ketamine, significantly reducing the dose needed for equivalent effects. Users report high variability in potency between batches. Harm reduction practices include volumetric dosing, nasal saline rinses after insufflation, setting strict session caps, and avoiding daily or weekly use to prevent urinary tract damage.

    Perspectives

    “I was sorry not to have sampled it earlier.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral / Sublingual BA ~50% 15-25mg 25-35mg 35-65mg 65-80mg+
    Insufflated BA ~60% 10-20mg 20-35mg 35-60mg 60mg+
    Oral BA ~50% 10-25mg 25-45mg 45-70mg 70mg+
    Sublingual 10-20mg 40-60mg 60-75mg 75mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral / Sublingual 15-45 min 45-90 min 1.0-3.0 hrs 2.0-3.0 hrs 2.0-48.0 hrs 3.0-5.0 hrs
    Insufflated 4-19 min 30-75 min 1.0-3.0 hrs 1.0-3.0 hrs 2.0-48.0 hrs 3.0-6.0 hrs
    Intramuscular 4-10 min 15-30 min 1.0-3.0 hrs 2.0-3.0 hrs 2.0-48.0 hrs 3.0-6.0 hrs
    Rectal 15-30 min 30-60 min 1.0-3.0 hrs 2.0-3.0 hrs 2.0-48.0 hrs 3.0-6.0 hrs
    Oral 12-30 min 48-90 min 1.5-2.5 hrs 60-90 min 6.0-48.0 hrs 3.0-6.0 hrs
    Sublingual 15-45 min - 3.0-6.0 hrs - 2.0-48.0 hrs 3.0-6.0 hrs

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction
    Cross-tolerance
    Ketamine Dextromethorphan PCP 3-MeO-PCP 3-HO-PCP 3-MeO-PCE 3-HO-PCE O-PCE

    Effects TheDrug.Wiki TripSit

    Positive
    • Pain relief
    • Creativity enhancement
    • Physical euphoria
    • Spontaneous tactile sensations
    • Stimulation
    Negative
    • Nausea
    • Numbness
    Neutral
    • Sedation
    • Tactile disconnection
    • Physical disconnection
    Positive
    • Cognitive euphoria
    • Conceptual thinking
    • Immersion enhancement
    • Introspection
    • Anxiety suppression
    • Analysis enhancement
    • Unity and interconnectedness
    Negative
    • Motor control loss
    • Depersonalization
    • Derealization
    • Compulsive redosing
    • Amnesia
    • Memory suppression
    • Dizziness
    • Information processing suppression
    • Mania
    • Thought deceleration
    Neutral
    • Consciousness disconnection
    • Time distortion
    • Ego death
    • Perspective alterations
    • Perspective distortions
    • Physical autonomy
    Positive
    • Perception of bodily lightness
    • Increased music appreciation
    Negative
    • Spatial disorientation
    • Tactile suppression
    • Visual acuity suppression
    • Double vision
    • Acuity suppression
    • Auditory suppression
    • Disinhibition
    • Frame rate suppression
    • Pattern recognition suppression
    Neutral
    • Visual disconnection
    • Auditory distortion
    • Auditory hallucinations
    • Autonomous entities
    • Environmental cubism
    • Environmental orbism
    • External hallucinations
    • Internal hallucinations
    • Perception of decreased weight
    • Scenery slicing
    • Visual sliding

    Combinations TripSit

    Trip Reports Effect Index

    The Expedition nervewing

    Helpful Links

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