Methoxetamine
Aliases: Mxe, Mexxy, M-ket, Roflcopter, 3-meo-2'oxo-pce
Summary
3-MeO-2'-Oxo-PCE (commonly known as Methoxetamine, MXE, Mexxy, among others) is a dissociative substance of the arylcyclohexylamine class that produces ketamine-like dissociative effects when administered. It is structurally related to ketamine, PCE, and 3-MeO-PCP. MXE was originally developed through the use of intelligent drug design, as a potential treatment for Phantom Limb Syndrome among other ailments.
Perspectives
“MXE is one of my favorite substances. The hole experience on it is substantially more colorful than with other dissociatives, it feels like an adventure is unfolding before me. It is stimulating and slightly manic, and highly euphoric. RIP MXE, you will be missed.”
“I was sorry not to have sampled it earlier.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual BA ~50% | 15-25mg | 25-35mg | 35-65mg | 65-80mg+ |
| Insufflated BA ~60% | 10-20mg | 20-35mg | 35-60mg | 60mg+ |
| Oral BA ~50% | 10-25mg | 25-45mg | 45-70mg | 70mg+ |
| Sublingual | 10-20mg | 40-60mg | 60-75mg | 75mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral / Sublingual | 15-45 min | 45-90 min | 1-3 hrs | 2-3 hrs | 3-5 hrs |
| Insufflated | 4-19 min | 30-75 min | 1-3 hrs | 1-3 hrs | 3-6 hrs |
| Intramuscular | 4-10 min | 15-30 min | 1-3 hrs | 2-3 hrs | 3-6 hrs |
| Rectal | 15-30 min | 30-60 min | 1-3 hrs | 2-3 hrs | 3-6 hrs |
| Oral | 12-30 min | 48-90 min | 1.5-2.5 hrs | 60-90 min | 3-6 hrs |
| Sublingual | 15-45 min | - | 3-6 hrs | - | 3-6 hrs |
Effect Profile
219 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 219 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth and insight with moderate mania and motor impairment
“It made all my problems wash away, you could say that I dissociated from them… I was heartbroken as hell, but that suddenly became a passing feeling, an irrelevancy to the wide world of MXE.”
“Specifically I've noticed that when I had a lucid dream recently the quality of the experience felt nearly the same as a 'lucid hole' that I had a couple days previously.”
“To me, I've already Died in the Hospital from a Heroin OD and they brought me back to Life - I've tried to take my Life during Manic Depressive Episodes................MXE has saved me from this...”
“I feel the rushing euphoria of the coming trip.”
“That's where it gets really interesting, and I am incorporating different pre-existing models of consciousness such as The Quantum Mind, Spin-Mediated Consciousness, Orch OR theory, quantum...”
“Is there such a thing as returning to being the same person after a meaningful experience?”
“I feel cold and numb, with some nausea and burgeoning ataxia.”
User Experience
Tolerance
Tolerance Decay
A single heavy session can produce pronounced short-term tolerance. Many users report tolerance halves over ~3–5 days and returns near-baseline after ~10–14 days; data are anecdotal and vary widely by dose pattern and ROA. Cross-tolerance within the arylcyclohexylamine class is expected. Data quality: anecdotal/community reports.
Cross-Tolerances
Effects
Aggregated from 219 Erowid experience reports