Methoxphenidine Limited data

Limited data

Sparse data. Doses and effects may be unreliable or untested.

6 corroborating sources

1 ROA with full dose ladder

duration data present

18 combo interactions documented

classified Tentative

classified Research-chemical

dose data not in PW/TripSit (unverifiable)

dose ladder unverifiable and undisclosed — capped

Aliases: Mxp, 2-mxp, Methoxyphenidine, 2-meo-diphenidine

Summary dose.wiki Erowid TripSit PsychonautWiki

Methoxphenidine (commonly called MXP or 2-MXP) is a long-acting dissociative of the diarylethylamine class with particularly extended duration. Oral onset can take 1-2 hours, leading inexperienced users to redose prematurely and experience severe intoxication. Doses above 150 mg have produced severe confusion, blackouts, urinary tract irritation similar to ketamine cystitis, and hospitalizations.

Perspectives

“Perhaps it’s the addition of cannabis, or my setting, but overall it provides an exciting and interesting experience that almost feels like an abraded and dulled down psychedelic, devoid of color and with a mysterious damper taking hold of my thoughts and moving them uncontrollably along some predetermined track. Overall it is very buzzy and vibrate-y.”

— Nervewing, nervewing.blogspot.com 150 mg oral

Dose Information dose.wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	50-75mg	75-120mg	120-150mg	150mg+

Light Common Strong Heavy

Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	0.5-2 hrs	30-60 min	2-5 hrs	2-3 hrs	6-24 hrs	6-8 hrs
Insufflated	10-45 min	15-30 min	2-4 hrs	1-2 hrs	6-24 hrs	6-8 hrs
Intravenous	30-60 min	-	2-3 hrs	1-2 hrs	6-12 hrs	6-8 hrs

Effect Profile

30 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 30 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Dissociative 6.0

Strong 6/10

Strong dissociative depth, mania, and motor impairment with moderate insight

Dissociative Depth ×3

depersonalization derealization consciousness disconnection tactile disconnection physical disconnection visual disconnection +6 more

⚠ Mania / Compulsion ×1

thought acceleration disinhibition stimulation euphoria

Insight / Novel Thought ×2

conceptual thinking perspective alterations perspective distortions

⚠ Motor / Sensory Impairment ×1

motor control loss tactile disconnection physical disconnection tactile suppression numbness spatial disorientation +2 more

Based on reports from:

Effect Index The Great Vibration Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki Methoxphenidine The Drug Users Bible Methoxphenidine

Add missing routes to PsychonautWiki Journal

The PsychonautWiki Journal app already has Methoxphenidine, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

⬇ Download import file Import this file as custom substances and you get "Methoxphenidine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Dose & duration (reference)

Methoxphenidine: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Insufflated dose (mg): threshold 5-10
Intravenous dose (mg): threshold 5

Insufflated duration: onset 10-45m · come-up 15-30m · peak 2-4h · offset 1-2h · total 6-8h · after-effects 6-24h
Intravenous duration: onset 0.5-1h · peak 2-3h · offset 1-2h · total 6-8h · after-effects 6-12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.

Tolerance

Build-up develops with repeated use over days to weeks

Reset 2–4 weeks for noticeable reduction

Tolerance Decay

Full tolerance 2d Half tolerance 7d Baseline ~21d

Rapid tolerance build is commonly reported with frequent dissociative use; decay back to baseline typically requires weeks. Values are heuristic aggregates from user reports across dissociatives; specific MXP kinetics are poorly characterized. Avoid consecutive-day use to limit escalation and compulsive redosing.

Cross-Tolerances

Ketamine

50%

DXM

40%

3-MeO-PCP and related arylcyclohexylamines

60%

Effects Erowid

Aggregated from 30 Erowid experience reports

Positive Effects 9

Music Enhancement 56.7% 70%

Empathy 46.7% 70%

Euphoria 40.0% 70%

Stimulation 40.0% 70%

Focus Enhancement 33.3% 70%

Tactile Enhancement 33.3% 70%

Introspection 30.0% 70%

Color Enhancement 26.7% 70%

Body High 26.7% 70%

Adverse Effects 8

Anxiety 56.7% 70%

Confusion 36.7% 70%

Memory Suppression 23.3% 70%

Increased Heart Rate 13.3% 70%

Headache 13.3% 70%

Nausea 13.3% 70%

Motor Impairment 10.0% 70%

Psychosis 10.0% 70%

Combinations TripSit

Cross-Check Methoxphenidine with another substance

Trip Reports Effect Index

The Great Vibration nervewing

Bluelight Reference Guide Bluelight

☛ Official ☚ The Big & Dandy Methoxphenidine / MXP Thread - Part 2 - 'Foxphenny Methoxphenny'?

The Methoxphenidine (2-MeO-Diphenidine) Thread iupac = 1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine ; (±)-1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine; (R/S)-1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine Link to the previous Big & Dandy thread Warnings - MUST read before use: - Long winded Duration: The duratio...

Read full thread on Bluelight →

Methoxphenidine's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki 📖 TripSit 📖 Bluelight 📖 The Drug Users Bible

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