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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Methoxphenidine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 6 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • classified Tentative
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Mxp, 2-mxp, Methoxyphenidine, 2-meo-diphenidine

    Dissociative Research-chemical

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Methoxphenidine (commonly called MXP or 2-MXP) is a long-acting dissociative of the diarylethylamine class with particularly extended duration. Oral onset can take 1-2 hours, leading inexperienced users to redose prematurely and experience severe intoxication. Doses above 150 mg have produced severe confusion, blackouts, urinary tract irritation similar to ketamine cystitis, and hospitalizations.

    Perspectives

    “MXP provides an exciting and interesting experience that almost feels like an abraded and dulled down psychedelic, devoid of color and with a mysterious damper taking hold of my thoughts. Overall it is very buzzy and vibrate-y.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 50-75mg 75-120mg 120-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 0.5-2 hrs 30-60 min 2-5 hrs 2-3 hrs 6-24 hrs 6-8 hrs
    Insufflated 10-45 min 15-30 min 2-4 hrs 1-2 hrs 6-24 hrs 6-8 hrs
    Intravenous 30-60 min - 2-3 hrs 1-2 hrs 6-12 hrs 6-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.3
    Strong 6/10

    Strong dissociative depth, motor impairment, and mania with moderate insight

    Dissociative Depth ×3
    10
    depersonalization derealization consciousness disconnection tactile disconnection physical disconnection visual disconnection +6 more
    ⚠ Mania / Compulsion ×1
    8
    thought acceleration disinhibition stimulation euphoria
    Insight / Novel Thought ×2
    6
    conceptual thinking perspective alterations perspective distortions
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss tactile disconnection physical disconnection tactile suppression numbness spatial disorientation +2 more
    Based on reports from:
    Effect Index The Great Vibration Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki Methoxphenidine The Drug Users Bible Methoxphenidine
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 2d Half tolerance 7d Baseline ~21d

    Rapid tolerance build is commonly reported with frequent dissociative use; decay back to baseline typically requires weeks. Values are heuristic aggregates from user reports across dissociatives; specific MXP kinetics are poorly characterized. Avoid consecutive-day use to limit escalation and compulsive redosing.

    Cross-Tolerances

    Ketamine
    50%
    DXM
    40%
    3-MeO-PCP and related arylcyclohexylamines
    60%

    Effects TheDrug.Wiki TripSit

    Positive
    • Physical euphoria
    • Pain relief
    • Spontaneous tactile sensations
    • Stimulation
    Negative
    • Clumsiness in movement
    • Increased heart rate
    • Numbness
    • Loss of balance
    Neutral
    • Tactile disconnection
    • Physical disconnection
    Positive
    • Cognitive euphoria
    • Conceptual thinking
    • Euphoria
    • Inner calm
    • Anxiety suppression
    Negative
    • Depersonalization
    • Derealization
    • Motor control loss
    • Memory suppression
    • Anxiety
    • Confusion
    • Amnesia
    • Dizziness
    • Information processing suppression
    • Thought deceleration
    Neutral
    • Time distortion
    • Dissociation
    • Altered perception of time
    • Astral projection
    • Consciousness disconnection
    • Perspective alterations
    • Perspective distortions
    • Physical autonomy
    • Thought acceleration
    Positive
    • Increased music appreciation
    • Perception of bodily lightness
    Negative
    • Spatial disorientation
    • Acuity suppression
    • Auditory suppression
    • Disinhibition
    • Double vision
    • Frame rate suppression
    • Pattern recognition suppression
    • Tactile suppression
    Neutral
    • Visual disconnection
    • Internal hallucinations
    • Warm vibration
    • Auditory distortion
    • Auditory hallucinations
    • Autonomous entities
    • Environmental cubism
    • Environmental orbism
    • Perception of decreased weight
    • Scenery slicing

    Combinations TripSit

    Cross-Check Methoxphenidine with another substance

    Trip Reports Effect Index

    The Great Vibration nervewing

    Bluelight Reference Guide Bluelight

    ☛ Official ☚ The Big & Dandy Methoxphenidine / MXP Thread - Part 2 - 'Foxphenny Methoxphenny'?

    The Methoxphenidine (2-MeO-Diphenidine) Thread iupac = 1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine ; (±)-1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine; (R/S)-1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine Link to the previous Big & Dandy thread Warnings - MUST read before use: - Long winded Duration: The duratio...

    Read full thread on Bluelight →
    Methoxphenidine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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