Summary
Data are extremely scarce: only one formal PiHKAL trial (100 mg oral produced no overt effects) and a handful of 2025 forum / Reddit self-experiments. Community consensus places active oral dosing somewhere in the low-hundreds of milligrams, broadly mirroring its ethyl homologue MBDB but requiring approximately 25-40% higher weight due to weaker serotonin release. Bluelight users describe mild 'wired but clear' stimulation, elevated heart-rate (90-110 bpm resting) and difficulty sleeping for over 8 hours after 200 mg or more. One vaper reported light euphoria, body warmth and jaw tension after 20-30 mg total free-base inhaled across an evening. Structure-activity discussion suggests Methyl-K behaves primarily as a dopamine reuptake inhibitor with limited oral bioavailability, explaining higher effective doses and the preference for intranasal / rectal routes to improve efficiency.
Perspectives
“There were no effects. I was busy and totally wound up and didn’t sleep until 3 a.m., but this was probably unrelated to the Me-K.”
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 30-60 min | 1-3 hrs | 2-3 hrs | 2-12 hrs |
| Insufflated | 5-15 min | 1-3 hrs | 2-3 hrs | 2-12 hrs |
| Rectal | - | 1-3 hrs | 2-3 hrs | 2-12 hrs |
| Vaporized / Smoked | 1-3 min | 1-3 hrs | 2-3 hrs | 2-12 hrs |
Tolerance
Effects
- Clean Mental Stimulation
- Stimulation
- Jaw Clenching
- Tachycardia
- Insomnia
- Post-use Fatigue
- Teeth grinding
- Increased heart rate
- Pupil dilation
- Vasoconstriction
- Subtle Empathogenic Warmth
- Mild Euphoria
- Increased Sociability
- Alertness enhancement
- Euphoria
- Wakefulness
- Anxiety
- Talkativeness
- Thought acceleration
- Time distortion
- Increased music appreciation
- Tactile enhancement
- Increased libido
- Tracers
- Color enhancement
- Pattern recognition enhancement
- Light sensitivity
- Dehydration
- Appetite suppression
- Disinhibition
Combinations
PiHKAL / TiHKAL
“There were no effects. I was busy and totally wound up and didn’t sleep until 3 a.m., but this was probably unrelated to the Me-K.”