Summary
Potency is in the microgram range; calibrated 0.1 mg precision scale or volumetric dosing is mandatory. Subjective duration (20-48 h) far exceeds the 2 h rat plasma half-life because of high receptor affinity and slow dissociation. Animal studies show rapid formation of Olney's lesions in the retrosplenial cortex at equivalent doses to 1 mg/kg; human relevance unknown but caution advised. Users commonly report pronounced macropsia/micropsia, spatial warping and auditory hallucinations rather than classic dissociative euphoria. Severe amnesia, insomnia and thought-disorder are typical above 100 ug.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | - | 50-100ug | - | - |
| Oral | - | 50-100ug | - | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral / Sublingual | 15-60 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 24-72 hrs | 1200-0 min |
| Insufflated | 10-30 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 24-72 hrs | 1200-0 min |
| Intramuscular | 5-15 min | 30-90 min | 4-10 hrs | 8-24 hrs | 24-72 hrs | 1200-0 min |
| Rectal | 15-45 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 24-72 hrs | 1200-0 min |
| Oral | 15-30 min | - | 20.0-36.0 hrs | - | 1.0-72.0 hrs | 1200-0 min |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Nystagmus
- Numbness
- Loss of balance
- Nausea
- Increased heart rate
- Pupil dilation
- Insomnia
- Sedation
Positive
- Euphoria
Negative
- Motor Control Loss
- Cognitive Impairment
- Memory Suppression
- Thought Disorganization
- Anxiety
- Profound Dissociation
- Time Dilation
- Ego Fragmentation
- Time distortion
Positive
- Tracers
- Color enhancement
- Increased music appreciation
- Tactile enhancement
- Enhanced tactile sensation
Negative
- Derealization
- Auditory Hallucinations
- Visual Distortions
- Drifting
- Auditory distortion