MK-801
Aliases: Dizocilpine, mk801
Summary
Potency is in the microgram range; calibrated 0.1 mg precision scale or volumetric dosing is mandatory. Subjective duration (20-48 h) far exceeds the 2 h rat plasma half-life because of high receptor affinity and slow dissociation. Animal studies show rapid formation of Olney's lesions in the retrosplenial cortex at equivalent doses to 1 mg/kg; human relevance unknown but caution advised.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | - | 50-100ug | - | - |
| Oral | - | 50-100ug | - | - |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral / Sublingual | 15-60 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 13.2-37 hrs |
| Insufflated | 10-30 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 13.2-36.5 hrs |
| Intramuscular | 5-15 min | 30-90 min | 4-10 hrs | 8-24 hrs | 12.6-35.8 hrs |
| Rectal | 15-45 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 13.2-36.8 hrs |
| Oral | 15-30 min | - | 20-36 hrs | - | 20.2-36.5 hrs |
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild motor impairment, dissociative depth, and mania
Tolerance
Tolerance Decay
Dissociatives exhibit rapid, session-level tolerance with slow decay over 1–3 weeks. Frequent redosing extends duration non-linearly and can escalate confusion/insomnia. Cross-tolerance within NMDA antagonists is expected but not quantified in humans; values are heuristic based on user reports and class effects.
Cross-Tolerances
Effects
Aggregated from 3 Erowid experience reports