O-PCE
Aliases: 2-dcnek, 2-oxo-pce, Eticyclidone, N-ethyldeschloroketamine, Deschloro-n-ethyl-ketamine, 2'-oxo-pce, opce
Summary
2'-Oxo-PCE (also known as as Eticyclidone, and O-PCE) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, stimulating and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like MXE, 3-MeO-PCE, and deschloroketamine and is speculated to produce its effects through its activity as an NMDA receptor antagonist. The structural similarities O-PCE shares with DCK and ketamine which has been speculated to have antibacterial properties, has raised some concern as to whether it also shares these properties as well.
Perspectives
“This is a spooky substance. It is one of the blankest and most neutral feeling dissociatives I have ever taken. It robs me entirely of emotions, it is neither euphoric nor dysphoric just incredibly blank and grey.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated BA ~70% | 3-6mg | 6-12mg | 12-20mg | 20mg+ |
| Oral BA ~50% | 3-5mg | 5-15mg | 15-25mg | 25mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 1-4 min | 4-15 min | 1-2 hrs | 1-2 hrs | 4-6 hrs |
| Oral | 19-40 min | 30-60 min | 2-3 hrs | 1-2 hrs | - |
Effect Profile
18 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth, mania, and motor impairment with low insight
Tolerance
Tolerance Decay
Rapid tolerance build and partial cross‑tolerance across arylcyclohexylamines are widely reported; values above are heuristic and based on anecdotal patterns. Space sessions 10–14 days when possible to reduce escalation risk.
Cross-Tolerances
Effects
Aggregated from 18 Erowid experience reports