O-PCE
Aliases: 2-dcnek, 2-oxo-pce, Eticyclidone, N-ethyldeschloroketamine, Deschloro-n-ethyl-ketamine, 2'-oxo-pce, opce
Categories
Summary
O-PCE is notably more stimulating than other dissociatives like ketamine or DCK, with stimulation prominent in the first half of the experience and dissociation in the second half. The substance is highly potent and carries significant risks of hypertension, tachycardia, mania, psychosis, and urinary tract toxicity with chronic use. Compulsive redosing is common. Users should employ volumetric dosing and avoid frequent use. Structural similarities to ketamine raise concerns about potential antibacterial properties that may compromise immune function, though this remains unconfirmed.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated BA ~70% | 3-6mg | 6-12mg | 12-20mg | 20mg+ |
| Oral BA ~50% | 3-5mg | 5-15mg | 15-25mg | 25mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Insufflated | 1-4 min | 4-15 min | 1.0-2.0 hrs | 1.0-2.0 hrs | 2.0-12.0 hrs | 4.0-6.0 hrs |
| Oral | 19-40 min | 30-60 min | 2.0-3.0 hrs | 1.0-2.0 hrs | 4.0-48.0 hrs | - |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Cross-tolerance
Effects
Positive
- Stimulation
- Physical euphoria
- Pain relief
- Analgesia
Negative
- Increased heart rate
- Nausea
- Numbness
- Loss of balance
- Physical disconnection
- Sedation
Positive
- Cognitive euphoria
- Conceptual thinking
Negative
- Dizziness
- Motor control loss
- Amnesia
- Compulsive redosing
- Depersonalization
- Derealization
- Mania
- Memory suppression
- Physical autonomy
- Time distortion
Positive
- Perception of bodily lightness
- Increased music appreciation
Negative
- Tactile suppression
- Pattern recognition suppression
- Disinhibition
- Spatial disorientation
- Visual drifting
- Environmental cubism
- Auditory distortion
- Visual disconnection