Tiletamine - Substance Search

Summary TheDrug.Wiki Erowid TripSit

Tiletamine is typically supplied as the veterinary anaesthetic Telazol (1:1 with zolazepam); pure API crystals now circulate on the grey market and are at least 2-3x the potency of ketamine by weight. Human pharmacokinetics are poorly studied, but polar bear and porcine data place the elimination half-life at approximately 1.8 hours with rapid hepatic N-deethylation. Nasal administration burns sharply due to low pH, so users dilute in 0.9% saline or switch to IM for harm reduction.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral / Sublingual	10-25mg	25-50mg	50-100mg	100mg+
Intramuscular	2.5-5mg	5-10mg	10-20mg	20mg+
Oral	10-25mg	25-50mg	50-100mg	100mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects
Oral / Sublingual	15-30 min	30-45 min	30-90 min	1-2 hrs	4-24 hrs
Insufflated	5-10 min	10-20 min	30-90 min	1-2 hrs	4-24 hrs
Intramuscular	2-5 min	5-10 min	30-90 min	1-2 hrs	4-24 hrs
Rectal	5-15 min	15-30 min	30-90 min	1-2 hrs	4-24 hrs
Oral	15-45 min	-	6-12 hrs	-	1-72 hrs

Effect Profile

13 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Dissociative 5.7

Strong 6/10

Strong dissociative depth and motor impairment with moderate mania, low insight

Dissociative Depth ×3

10

depersonalization derealization physical disconnection cognitive disconnection visual disconnection spatial disorientation +2 more

⚠ Mania / Compulsion ×1

6

disinhibition stimulation euphoria

Insight / Novel Thought ×2

3

conceptual thinking

⚠ Motor / Sensory Impairment ×1

10

motor control loss physical disconnection tactile suppression spatial disorientation visual disconnection double vision

Based on reports from:

Erowid Experience Reports PsychonautWiki Tiletamine

Tolerance

Build-up develops with repeated use over days to weeks

Reset 2–4 weeks for noticeable reduction

Tolerance Decay

Full tolerance 1d Half tolerance 3d Baseline ~10d

Tolerance to dissociatives can develop rapidly over a single session and decays over ~7–14 days; values reflect anecdotal community observations and general dissociative patterns rather than controlled human data.

Cross-Tolerances

ketamine

70%

PCP analogues (e.g., O-PCE)

60%

MXE

60%

Effects Erowid

Aggregated from 13 Erowid experience reports

Positive Effects 3

Euphoria 38.5% 70%

Color Enhancement 30.8% 70%

Sedation 30.8% 70%

Adverse Effects 0

Combinations TripSit

Tiletamine's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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