Tiletamine: a fun obscure dissociative. It is legal in Canada and is able to be ordered from Research chemical Vendors. Though it is more expensive than ketamine so its not terribly popular even among those who like it.
Tiletamine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: O-tce, Ci-634, Cl-399, Telazol, Zoletil
Summary
Tiletamine is typically supplied as the veterinary anaesthetic Telazol (1:1 with zolazepam); pure API crystals now circulate on the grey market and are at least 2-3x the potency of ketamine by weight. Human pharmacokinetics are poorly studied, but polar bear and porcine data place the elimination half-life at approximately 1.8 hours with rapid hepatic N-deethylation. Nasal administration burns sharply due to low pH, so users dilute in 0.9% saline or switch to IM for harm reduction.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 10-25mg | 25-50mg | 50-100mg | 100mg+ |
| Intramuscular | 2.5-5mg | 5-10mg | 10-20mg | 20mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral / Sublingual | 15-30 min | 30-45 min | 30-90 min | 1-2 hrs |
| Insufflated | 5-10 min | 10-20 min | 30-90 min | 1-2 hrs |
| Intramuscular | 2-5 min | 5-10 min | 30-90 min | 1-2 hrs |
| Rectal | 5-15 min | 15-30 min | 30-90 min | 1-2 hrs |
Effect Profile
13 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
5.7
Strong
6/10
Strong dissociative depth and motor impairment with moderate mania, low insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
spatial disorientation
+2 more
Mania / Compulsion
×1
6
disinhibition
stimulation
euphoria
Insight / Novel Thought
×2
3
conceptual thinking
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
spatial disorientation
visual disconnection
double vision
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
14d
Baseline
~28d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance to dissociatives can develop rapidly over a single session and decays over ~7–14 days; values reflect anecdotal community observations and general dissociative patterns rather than controlled human data.
Cross-Tolerances
Effects
Aggregated from 13 Erowid experience reports
Positive Effects 3
Euphoria
38.5%
70%
Color Enhancement
30.8%
70%
Sedation
30.8%
70%
Adverse Effects 0
Combinations
Cross-Check Tiletamine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 6 neutral 2 cautionary visit
In the spirit of Halloween I decided to try something new to me and previously untested... Would this unknown candy apple be a terrible trick or a tasty treat??? The compound in question was tiletamine, a structural relative of ketamine that's also used in animals as a veterinary anesthetic.
This was arguably the most bizarre experience I've had on a drug before, I never imagined that a substance could bend the mind to such a degree. It was about 6 pm on a Friday and I had received a package of 250 mg. of Tiletamine HCl, made by a reputable research chemical distributor in my country.
30 mg of Tiletamine 3 capsules of Tiletamine were purchased in Moscow through the dead-drop system. According to the seller, one capsule contains 30 mg of pure Tiletamine. I opened one capsule and licked a couple of crumbs, they tasted a little bitter with a sour aftertaste. I decided to try it at 2 AM, at home.
This will be a short report as there isn't much information about Tiletamine on the internet and i really think people should know just how horrible this stuff is. People have been selling Tiletamine as Ketamine in my area. It is imported from China I believe and a lot easier and cheaper to get hold of.
lately i have been using special k regularly. I have been to every level obtainable from the shit. The K-h0le did not scare me it just made me think I was the universe. I was one with everything and i have been in the television shows. Then I started searching for some other type of disassociative anasthesias.
1st experience: I came across this stuff which was described to me as 'Doggy K' The person selling it to us had gotten it from a friend who had worked in a animal hospital. We figured why not try it? It was being offered at a cheaper price and there was no Ketamine to be found.
In 1993 I experienced events leading to operating as a child soldier, many of the experiences were subdued due to nuclear medicine's interest in chemical retraint of memory recall however as a human I felt a necessity to probe the memory region of my mind which I felt contained an important piece of my life.
Bluelight 1 thread 1 neutral visit
Tiletamine Experience Report To start this off, I consider myself to have pretty minimal experience with disso substances. When I say this, to be exact, I have personally only used 2 other disso substances. Those substances being DCK and O-PCE. Therefore I only have those substances to compare to.
Tiletamine's nerd page
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