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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Tiletamine

    Aliases: O-tce, Ci-634, Cl-399, Telazol, Zoletil

    Categories

    Depressant Dissociative Research-chemical
    Tiletamine structure

    Summary TheDrug.Wiki Erowid TripSit

    Tiletamine is typically supplied as the veterinary anaesthetic Telazol (1:1 with zolazepam); pure API crystals now circulate on the grey market and are at least 2-3x the potency of ketamine by weight. Human pharmacokinetics are poorly studied, but polar bear and porcine data place the elimination half-life at approximately 1.8 hours with rapid hepatic N-deethylation. Nasal administration burns sharply due to low pH, so users dilute in 0.9% saline or switch to IM for harm reduction. Repeated use has produced prolonged tremor syndromes, cerebellar ataxia, choreiform movements and week-long cognitive depersonalisation even at doses under 30 mg insufflated. Forum consensus caps single doses at 30 mg or below and total session load at 60 mg or below to minimise neuro-excitation.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral / Sublingual 10-25mg 25-50mg 50-100mg 100mg+
    Intramuscular 2.5-5mg 5-10mg 10-20mg 20mg+
    Oral 10-25mg 25-50mg 50-100mg 100mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral / Sublingual 15-30 min 30-45 min 30-90 min 1-2 hrs 4-24 hrs
    Insufflated 5-10 min 10-20 min 30-90 min 1-2 hrs 4-24 hrs
    Intramuscular 2-5 min 5-10 min 30-90 min 1-2 hrs 4-24 hrs
    Rectal 5-15 min 15-30 min 30-90 min 1-2 hrs 4-24 hrs
    Oral 15-45 min - 6.0-12.0 hrs - 1.0-72.0 hrs

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction
    Cross-tolerance
    Ketamine PCP Methoxetamine

    Effects TheDrug.Wiki

    Positive
    • Physical euphoria
    • Stimulation
    • Pain relief
    Negative
    • Nystagmus
    • Muscle spasms
    • Motor impairment
    • Nausea
    Neutral
    • Physical disconnection
    • Anesthesia
    • Sedation
    Positive
    • Euphoria
    • Cognitive euphoria
    • Conceptual thinking
    Negative
    • Cognitive disconnection
    • Depersonalization
    • Derealization
    • Motor control loss
    • Memory suppression
    • Amnesia
    Neutral
    • Time distortion
    Positive
    • Immersive dissociative geometry
    • Increased music appreciation
    Negative
    • Tactile suppression
    • Disinhibition
    • Spatial disorientation
    • Double vision
    Neutral
    • Visual disconnection
    • Auditory hallucinations
    • Dulled perception
    • Auditory distortion

    Combinations TripSit

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