Summary
Tilmetamine (2-(methylamino)-2-(thiophen-2-yl)cyclohexan-1-one) is the N-methyl homolog of Til-ET-amine that reached grey-market vendors in 2024. Community reports place potency roughly five to seven times that of ketamine: 2-5 mg insufflated already produces dissociation, while 10-20 mg has left users with vertigo, tremor, depersonalisation, and dysphoria lasting days. The powder is hygroscopic and clings electrostatically, so volumetric dosing in PG or an ethanol-water mix (for example 10 mg/mL) is far safer than chasing individual milligram shards. Vendors advertise rapid onset (1-10 minutes IM/IN) and a 1-2 hour elimination half-life, yet many users describe a heavier body-load than ketamine with little euphoria and pronounced after-effects. Stacking doses easily leads to ataxia and next-day fatigue; start with micro-doses, avoid redosing, and assume full cross-tolerance with other arylcyclohexylamines.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Insufflated | 5-15 min | 20-40 min | 0.5-2 hrs | 6-12 hrs | 24-72 hrs |
Tolerance
Effects
- Analgesia
- Physical euphoria
- Stimulation
- Vertigo
- Muscle tremors
- Numbness
- Loss of balance
- Nausea
- Physical disconnection
- Sedation
- Conceptual thinking
- Cognitive euphoria
- Motor control loss
- Depersonalization
- Derealization
- Cognitive fog
- Amnesia
- Dissociation
- Physical autonomy
- Time distortion
- Auditory enhancement
- Increased music appreciation
- Spatial disorientation
- Derealization
- Disinhibition
- Tactile suppression
- Double vision
- Visual distortions
- Auditory distortion
- Visual disconnection