Tilmetamine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
Tilmetamine (2-(methylamino)-2-(thiophen-2-yl)cyclohexan-1-one) is the N-methyl homolog of Til-ET-amine that reached grey-market vendors in 2024. Community reports place potency roughly five to seven times that of ketamine: 2-5 mg insufflated already produces dissociation, while 10-20 mg has left users with vertigo, tremor, depersonalisation, and dysphoria lasting days. The powder is hygroscopic and clings electrostatically, so volumetric dosing in PG or an ethanol-water mix (for example 10 mg/mL) is far safer than chasing individual milligram shards.
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
Dose basis. Ranges below are inferred primarily from user reports; large inter-batch variability and frequent mislabeling (tilmetamine vs tiletamine) have been documented. Use an accurate 0.1 mg scale and strongly consider volumetric dosing for sub-10 mg accuracy. Start at the lowest end and do not redose for at least 24 hours until delayed adverse effects are ruled out. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 2-5mg | 5-10mg | 10-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 5-15 min | 20-40 min | 0.5-2 hrs | 6-12 hrs | 6.91-14.92 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth and motor impairment with mild mania, low insight
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Tilmetamine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Tilmetamine Source: SubstanceSearch (substancesearch.com) Insufflated dose (mg): threshold 1-2 · light 2-5 · common 5-10 · strong 10-20 · heavy 20+ Insufflated duration: onset 5-15m · come-up 20-40m · peak 0.5-2h · offset 6-12h · total 6.91-14.92h · after-effects 24-72h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 7.5 mg (Insufflated).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Rapid tolerance buildup is frequently reported with arylcyclohexylamines; figures are qualitative and based on community patterns rather than formal PK. Space sessions by several weeks to reduce risk of lingering adverse effects.
Cross-Tolerances
Effects
- Analgesia
- Physical euphoria
- Stimulation
- Vertigo
- Muscle tremors
- Numbness
- Loss of balance
- Nausea
- Physical disconnection
- Sedation
- Conceptual thinking
- Cognitive euphoria
- Motor control loss
- Depersonalization
- Derealization
- Cognitive fog
- Amnesia
- Dissociation
- Physical autonomy
- Time distortion
- Auditory enhancement
- Increased music appreciation
- Spatial disorientation
- Derealization
- Disinhibition
- Tactile suppression
- Double vision
- Visual distortions
- Auditory distortion
- Visual disconnection
Combinations
Cross-Check Tilmetamine with another substanceHelpful Links
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