Tilmetamine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
Tilmetamine (2-(methylamino)-2-(thiophen-2-yl)cyclohexan-1-one) is the N-methyl homolog of Til-ET-amine that reached grey-market vendors in 2024. Community reports place potency roughly five to seven times that of ketamine: 2-5 mg insufflated already produces dissociation, while 10-20 mg has left users with vertigo, tremor, depersonalisation, and dysphoria lasting days. The powder is hygroscopic and clings electrostatically, so volumetric dosing in PG or an ethanol-water mix (for example 10 mg/mL) is far safer than chasing individual milligram shards.
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 2-5mg | 5-10mg | 10-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Insufflated | 5-15 min | 0.5-2 hrs | 6-12 hrs | 8-24 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth and motor impairment with mild mania, low insight
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Rapid tolerance buildup is frequently reported with arylcyclohexylamines; figures are qualitative and based on community patterns rather than formal PK. Space sessions by several weeks to reduce risk of lingering adverse effects.
Cross-Tolerances
Effects
- Analgesia
- Physical euphoria
- Stimulation
- Vertigo
- Muscle tremors
- Numbness
- Loss of balance
- Nausea
- Physical disconnection
- Sedation
- Conceptual thinking
- Cognitive euphoria
- Motor control loss
- Depersonalization
- Derealization
- Cognitive fog
- Amnesia
- Dissociation
- Physical autonomy
- Time distortion
- Auditory enhancement
- Increased music appreciation
- Spatial disorientation
- Derealization
- Disinhibition
- Tactile suppression
- Double vision
- Visual distortions
- Auditory distortion
- Visual disconnection
Combinations
Cross-Check Tilmetamine with another substanceHelpful Links
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