Preface: TMA-2 is a psychedelic amphetamine closely related to mescaline. TMA-2 is just one of a series of the compounds known as the TMAs- short for TriMethoxy Amphetamine. As the name suggests, these are amphetamines with 3-methoxy groups.
TMA-2
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: Domeo, 2,5-dimethoxy-4-methoxyamphetamine
Summary
TMA-2 (2,5-dimethoxy-4-methoxyamphetamine) is a synthetic psychedelic amphetamine. It is notably more potent than its positional isomer TMA (3,4,5-trimethoxyamphetamine) and has a limited history of human use. TMA-2 is known for producing unique stimulating effects with less pronounced visual distortions compared to mescaline. Anecdotal reports indicate it is dose-sensitive and can produce uncomfortable body load, nausea, and overstimulation.
Perspectives
“TMA-2 is a challenging but rewarding experience, worthwhile for those willing to suffer the massive lingering bodyload and the overwrought, nonstop stimulation.”
“I took it in two 10 milligram doses, spaced by two hours. There was a slight movement of surface textures, my hearing was deepened and spatially defined. The body was relaxed and stretching seemed necessary. The further I got into it the more I realized that I was totally lazy. Very lethargic, to the point of laughter. At the sixth hour, I was seeing more life in the woodwork, and the wooden angel hanging on the ceiling was flesh and feathers when I stared at it. Great vision. But by no means overwhelming. Sleep was fine.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-20mg | 20-40mg | 40-60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.33-2 hrs | 1.5-3 hrs | 4-6 hrs | 2-4 hrs | 6-12 hrs |
| Insufflated | 10-30 min | 30-60 min | 4-6 hrs | 2-4 hrs | 6-12 hrs |
| Rectal | 10-30 min | 30-60 min | 4-7 hrs | 3-5 hrs | 6-12 hrs |
| Vaporized | 5-15 min | 20-40 min | 3-6 hrs | 2-4 hrs | 6-12 hrs |
Effect Profile
32 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 32 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.8
Intense+
9/10
Strong visuals, headspace, auditory effects, and body load
Visual Intensity
×3
10
color enhancement
drifting
pattern recognition enhancement
color shifting
after images
brightened colour
+1 more
Headspace Depth
×3
10
conceptual thinking
thought connectivity
emotion enhancement
time distortion
confusion
Auditory Effects
×1
10
auditory distortion
music appreciation enhancement
Body Load / Somatic Effects
×1
10
vasoconstriction
nausea
muscle tension
Stimulant
7.0
Strong+
7/10
Strong stimulation, anxiety/jitters, and focus with mild euphoria
Stimulation / Energy
×3
10
stimulation
wakefulness
Euphoria / Mood Lift
×2
5
euphoria
Focus / Productivity
×2
8
analysis enhancement
thought acceleration
Anxiety / Jitters
×1
10
restlessness
vasoconstriction
muscle tension
Based on reports from:
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has TMA-2, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "TMA-2 (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Dose & duration (reference)
TMA-2: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Insufflated dose (mg): threshold 5-10 Rectal dose (mg): threshold 5-10 Vaporized dose (mg): threshold 5-10 Insufflated duration: onset 10-30m ยท come-up 0.5-1h ยท peak 4-6h ยท offset 2-4h ยท total 6-12h ยท after-effects 6-12h Rectal duration: onset 10-30m ยท come-up 0.5-1h ยท peak 4-7h ยท offset 3-5h ยท total 6-12h ยท after-effects 6-12h Vaporized duration: onset 5-15m ยท come-up 20-40m ยท peak 3-6h ยท offset 2-4h ยท total 6-12h ยท after-effects 4-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3โ7 days for acute; 1โ3 weeks for full reset
Tolerance Decay
Full tolerance
6h
Half tolerance
3d
Baseline
~21d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Acute tolerance develops within hours like other serotonergic psychedelics; functional tolerance typically halves over ~3 days and largely resolves within ~7โ14 days. Crossโtolerance with other classical psychedelics is expected via 5โHT2A downregulation; ratios are rough heuristic values from general psychedelic literature, not TMAโ2 specific measurements.
Cross-Tolerances
Effects
Aggregated from 32 Erowid experience reports
Positive Effects 9
Stimulation
59.4%
70%
Color Enhancement
56.2%
70%
Music Enhancement
56.2%
70%
Tactile Enhancement
31.2%
70%
Euphoria
28.1%
70%
Empathy
28.1%
70%
Focus Enhancement
28.1%
70%
Introspection
25.0%
70%
Body High
18.8%
70%
Adverse Effects 11
Nausea
50.0%
70%
Anxiety
37.5%
70%
Muscle Tension
34.4%
70%
Pupil Dilation
18.8%
70%
Confusion
15.6%
70%
Increased Heart Rate
12.5%
70%
Headache
9.4%
70%
Sweating
9.4%
70%
Psychosis
9.4%
70%
Jaw Clenching
9.4%
70%
Motor Impairment
9.4%
70%
Combinations
Cross-Check TMA-2 with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 3 positive 5 neutral visit
**I didnยt change much from the original notes I made during the trip so you have a better understanding of how I felt during the trip. My conclusion is at the bottom.** ยยยยยยยยยยยยยยยยยยยยยยยยย **Preface:** After having tried 3,4,5-trimethoxyamphetamine (TMA) in February, I decided to check off the other trimethoxyla...
I recently tried TMA-2 for the first time, at 30mg. I'm male, 22, and ~150lbs. I have previous experience with 2C-I,B,E,T2, and Mescaline. I hadn't ingested any psychoactive in almost a year, following a few difficult experiences. This was my first experience with a psychedelic amphetamine.
Relevant Personal Experience: Considerable experience with LSD, MDMA, psilocybin, and various forms of DMT, plus flips and other combinations. Minimal experience with mescaline and analogues: one positive San Pedro ceremony, one okay 2C-B experience (22mg), positive nexus flip and allie flip.
Dissolved Into Life, TMA-2 Recently, I was able to try a compound that I've had a lot of interest in since I ever read Pihkal almost 20 years ago. This compound is TMA-2 (HCL).
I was not expecting much. My boyfriend Z had acquired four TMA-2 capsules the previous year, and had tried a capsule out together with a mutual friend. His only comment afterwards was that the sunset had been particularly stunning, and I had not pressed for further details.
I'd always been interested in TMA-2, its been on the top of my list of RC's to sample for awhile, so when i came into 200mg i was stoked. It is very chemically similar to mescaline, however my interest stemmed from working with an extract of acorus gramineus last year.
[Erowid Note: Driving while intoxicated, tripping, or extremely sleep deprived is dangerous and irresponsible because it endangers other people. Don't do it! ] To 'All the Presidents Men' - with no clear visual distortion. I MUST REMEMBER - an ASC need not have visual disruption as a symptom!.
PiHKAL / TiHKAL
PiHKAL #158: TMA-2
“I took it in two 10 milligram doses, spaced by two hours. There was a slight movement of surface textures, my hearing was deepened and spatially defined. The body was relaxed and stretching seemed necessary. The further I got into it the more I realized that I was totally lazy. Very lethargic, to the point of laughter. At the sixth hour, I was seeing more life in the woodwork, and the wooden angel hanging on the ceiling was flesh and feathers when I stared at it. Great vision. But by no means overwhelming. Sleep was fine.”
TMA-2's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for TMA-2? Let us know. Reports are reviewed by moderators — this is not posted publicly.