TMA-2
Aliases: Domeo, 2,5-dimethoxy-4-methoxyamphetamine
Summary
TMA-2 is a synthetic psychedelic amphetamine that is notably more potent than its positional isomer TMA (3,4,5-trimethoxyamphetamine). It has a limited history of human use and is known for producing unique stimulating effects with less pronounced visual distortions compared to mescaline. Anecdotal reports indicate TMA-2 is dose-sensitive and can produce uncomfortable body load, nausea, and overstimulation.
Perspectives
“TMA-2 is a challenging but rewarding experience, worthwhile for those willing to suffer the massive lingering bodyload and the overwrought, nonstop stimulation.”
“I took it in two 10 milligram doses, spaced by two hours. There was a slight movement of surface textures, my hearing was deepened and spatially defined. The body was relaxed and stretching seemed necessary. The further I got into it the more I realized that I was totally lazy. Very lethargic, to the point of laughter. At the sixth hour, I was seeing more life in the woodwork, and the wooden angel hanging on the ceiling was flesh and feathers when I stared at it. Great vision. But by no means overwhelming. Sleep was fine.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-20mg | 20-40mg | 40-60mg | 60mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.33-2 hrs | 1.5-3 hrs | 4-6 hrs | 2-4 hrs | 7.8-15 hrs |
| Insufflated | 10-30 min | 30-60 min | 4-6 hrs | 2-4 hrs | 6.7-11.5 hrs |
| Rectal | 10-30 min | 30-60 min | 4-7 hrs | 3-5 hrs | 7.7-13.5 hrs |
Effect Profile
32 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 32 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals, headspace, auditory effects, and body load
Strong stimulation, anxiety/jitters, and focus with mild euphoria
Tolerance
Tolerance Decay
Acute tolerance develops within hours like other serotonergic psychedelics; functional tolerance typically halves over ~3 days and largely resolves within ~7–14 days. Cross‑tolerance with other classical psychedelics is expected via 5‑HT2A downregulation; ratios are rough heuristic values from general psychedelic literature, not TMA‑2 specific measurements.
Cross-Tolerances
Effects
Aggregated from 32 Erowid experience reports
Positive Effects 9
Adverse Effects 11
Combinations
PiHKAL / TiHKAL
“I took it in two 10 milligram doses, spaced by two hours. There was a slight movement of surface textures, my hearing was deepened and spatially defined. The body was relaxed and stretching seemed necessary. The further I got into it the more I realized that I was totally lazy. Very lethargic, to the point of laughter. At the sixth hour, I was seeing more life in the woodwork, and the wooden angel hanging on the ceiling was flesh and feathers when I stared at it. Great vision. But by no means overwhelming. Sleep was fine.”