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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-MAPB Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Stimulant Research-chemical

    Summary dose.wiki

    Very limited human data exist. 2-MAPB appears pharmacologically similar to MDMA based on rodent studies. Potency varies between vendors; always reagent-test samples.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Ranges are compiled from community reports on benzofurans and should be treated as approximate. Potency varies between vendors and batches; start at the low end after reagent/drug checking. Avoid redosing to reduce cardiovascular/serotonergic burden. Evidence base: user reports on benzofurans (e.g., 5‑MAPB) and harm‑reduction advisories. Insufflation increases local irritation risk and faster spikes in HR/BP; many benzofurans are reported as caustic intranasally. Prefer oral for smoother kinetics. Evidence base: community reports for benzofurans. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 20-60mg 60-110mg 110-140mg 140mg+ (not recommended)
    Insufflated 10-25mg 25-50mg 50-80mg 80mg+ (strongly discouraged)
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-80 min 30-60 min 1-3 hrs 2-3 hrs 2-24 hrs 4-8.33 hrs
    Insufflated 5-20 min 15-30 min 1-2 hrs 1-2 hrs 2-24 hrs 2.33-4.83 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 6.3
    Strong 6/10

    Moderate empathy, stimulation, and sensory enhancement with mild euphoria

    Empathy / Social Openness ×3
    7
    empathy enhancement sociability enhancement increased sociability
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    6
    tactile enhancement visual acuity enhancement increased libido
    Stimulant 3.6
    Moderate 4/10

    Strong anxiety/jitters with mild stimulation and euphoria, low focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    5
    euphoria mood lift
    Focus / Productivity ×2
    2
    thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety bruxism increased heart rate teeth grinding vasoconstriction
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-MAPB there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2-MAPB (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2-MAPB
    Unit
    mg
    Description 
    2-MAPB
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10-20 · light 20-60 · common 60-110 · strong 110-140 · heavy 140+ (not recommended)
Insufflated dose (mg): threshold 5-10 · light 10-25 · common 25-50 · strong 50-80 · heavy 80+ (strongly discouraged)

Oral duration: onset 0.5-1.33h · come-up 0.5-1h · peak 1-3h · offset 2-3h · total 4-8.33h · after-effects 2-24h
Insufflated duration: onset 5-20m · come-up 15-30m · peak 1-2h · offset 1-2h · total 2.33-4.83h · after-effects 2-24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 85 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Half tolerance 14d Baseline ~35d

    Extrapolated from MDMA/benzofuran user patterns: acute tolerance rises rapidly within a session and decays over weeks; spacing ≥4–6 weeks helps restore baseline response. Data quality is anecdotal; no controlled human tolerance studies for 2‑MAPB identified.

    Cross-Tolerances

    MDMA
    50%
    MDA
    50%
    5-APB / 6-APB
    50%
    Other MAPB/APB analogues
    50%

    Effects dose.wiki

    Positive
    • Stimulation
    Negative
    • Pupil dilation
    • Bruxism
    • Vasoconstriction
    • Increased heart rate
    • Increased blood pressure
    • Insomnia
    • Nausea
    • Teeth grinding
    Neutral
    • Difficulty urinating
    Positive
    • Empathy enhancement
    • Euphoria
    • Sociability enhancement
    • Wakefulness
    • Increased sociability
    • Mood lift
    Negative
    • Anxiety
    • Thought deceleration
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Tactile enhancement
    • Music appreciation
    • Visual acuity enhancement
    • Increased music appreciation
    • Bodily control enhancement
    • Increased libido
    • Tracers
    Negative
    • Light sensitivity
    Neutral
    • Auditory hallucination
    • Auditory distortion

    Combinations

    Cross-Check 2-MAPB with another substance

    2-MAPB's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki