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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-MAPB Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Stimulant Research-chemical

    Summary TheDrug.Wiki

    Very limited human data exist. 2-MAPB appears pharmacologically similar to MDMA based on rodent studies. Potency varies between vendors; always reagent-test samples.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 20-60mg 60-110mg 110-140mg 140mg+
    Insufflated 10-25mg 25-50mg 50-80mg 80mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-80 min 1.5-3 hrs 2-3 hrs 2-24 hrs 5-8 hrs
    Insufflated 30-80 min 1.5-3 hrs 2-3 hrs 2-24 hrs 5-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 6.3
    Strong 6/10

    Moderate empathy, stimulation, and sensory enhancement with mild euphoria

    Empathy / Social Openness ×3
    7
    empathy enhancement sociability enhancement increased sociability
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    6
    tactile enhancement visual acuity enhancement increased libido
    Stimulant 3.6
    Moderate 4/10

    Strong anxiety/jitters with mild stimulation and euphoria, low focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    5
    euphoria mood lift
    Focus / Productivity ×2
    2
    thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety bruxism increased heart rate teeth grinding vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 2-MAPB
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 14d Baseline ~35d

    Extrapolated from MDMA/benzofuran user patterns: acute tolerance rises rapidly within a session and decays over weeks; spacing ≥4–6 weeks helps restore baseline response. Data quality is anecdotal; no controlled human tolerance studies for 2‑MAPB identified.

    Cross-Tolerances

    MDMA
    50%
    MDA
    50%
    5-APB / 6-APB
    50%
    Other MAPB/APB analogues
    50%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    Negative
    • Pupil dilation
    • Bruxism
    • Vasoconstriction
    • Increased heart rate
    • Increased blood pressure
    • Insomnia
    • Nausea
    • Teeth grinding
    Neutral
    • Difficulty urinating
    Positive
    • Empathy enhancement
    • Euphoria
    • Sociability enhancement
    • Wakefulness
    • Increased sociability
    • Mood lift
    Negative
    • Anxiety
    • Thought deceleration
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Tactile enhancement
    • Music appreciation
    • Visual acuity enhancement
    • Increased music appreciation
    • Bodily control enhancement
    • Increased libido
    • Tracers
    Negative
    • Light sensitivity
    Neutral
    • Auditory hallucination
    • Auditory distortion

    Combinations TripSit

    Cross-Check 2-MAPB with another substance

    2-MAPB's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki