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    Disclaimer
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25H-NBOMe Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 4 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: 25h, 2c-h-nbome, Nbome-2c-h, 25-h-nbome

    Psychedelic Stimulant Research-chemical

    Summary dose.wiki TripSit

    25H-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-H. Compared with halogenated NBOMes (25I/25C/25B), it shows drastically weaker 5-HT2A potency (approximately 675-fold lower than 25I-NBOMe in vitro) and a pronounced adrenergic/vasoconstrictive profile. Because of low psychedelic potency, users may attempt multi-milligram doses, greatly increasing peripheral toxicity risk (tachycardia, hypertension, vasospasm).

    Dose Information dose.wiki TripSit Drugs.Wiki

    Dose basis. Sparse human data; numbers below are aggregated from scattered anecdotal reports and should not be treated as targets. Because NBOMes can be active at sub‑milligram levels and weighing errors are common, volumetric dosing (dissolving a precisely weighed amount into a known volume) is strongly recommended. Avoid redosing within the same session due to delayed peaks and vasoconstriction risk. Do not swallow expecting inactivity; some NBOMes show uncertain oral bioavailability. Insufflation markedly increases adverse effects and overdose risk with NBOMes (rapid spike, intense vasoconstriction, severe local irritation). Many harm‑reduction groups advise against this ROA for NBOMes; avoid if possible. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Sublingual 1-3mg 3-6mg 6-10mg 10mg+ (NOT RECOMMENDED)
    Insufflated 0.5-1.5mg 1.5-3mg 3-5mg 5mg+ (NOT RECOMMENDED)
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 15-45 min 30-60 min 1-3 hrs 2-4 hrs 2-6 hrs 3-5 hrs
    Insufflated 5-15 min 15-30 min 1-3 hrs 2-4 hrs 2-6 hrs 3-5 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.2
    Moderate+ 5/10

    Strong body load and visuals with moderate headspace

    Visual Intensity ×3
    8
    colour enhancement drifting pattern recognition enhancement brightened colour visual acuity enhancement
    Headspace Depth ×3
    6
    conceptual thinking emotion enhancement confusion time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    10
    vasoconstriction temperature regulation suppression nausea muscle tension increased heart rate
    Stimulant 3.6
    Moderate 4/10

    Strong anxiety/jitters with mild stimulation and focus, low euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    3
    euphoria
    Focus / Productivity ×2
    4
    analysis enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness paranoia increased heart rate vasoconstriction muscle tension
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25H-NBOMe there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "25H-NBOMe (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    25H-NBOMe
    Unit
    mg
    Description 
    25H-NBOMe
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (mg): threshold 0.5 · light 1-3 · common 3-6 · strong 6-10 · heavy 10+ (NOT RECOMMENDED)
Insufflated dose (mg): threshold 0.2 · light 0.5-1.5 · common 1.5-3 · strong 3-5 · heavy 5+ (NOT RECOMMENDED)

Sublingual duration: onset 15-45m · come-up 0.5-1h · peak 1-3h · offset 2-4h · total 3-5h · after-effects 2-6h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-3h · offset 2-4h · total 3-5h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 4.5 mg (Sublingual).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~14d

    Cross‑tolerance among serotonergic psychedelics is expected due to 5‑HT2A receptor desensitization. Many users report markedly blunted effects if re‑dosing within 1–2 weeks after NBOMe exposure; some describe longer cross‑tolerance windows with higher doses. Data remain anecdotal and variable.

    Cross-Tolerances

    LSD
    60%
    Psilocybin
    60%
    Other NBOMes
    80%
    2C-x
    50%
    DOx
    50%

    Effects dose.wiki TripSit

    Positive
    • Stimulation
    • Mental/physical stimulation
    Negative
    • Pupil dilation
    • Increased heart rate
    • Increased blood pressure
    • Vasoconstriction
    • Temperature regulation suppression
    • Muscle tension
    • Nausea
    • Restlessness
    • Sweating/chills
    • Insomnia
    Neutral
    • Mouth numbing
    • Decreased appetite
    Positive
    • Analysis enhancement
    • Conceptual thinking
    • Emotion enhancement
    • Wakefulness
    • Euphoria
    • Empathy
    • Insight
    Negative
    • Thought deceleration
    • Anxiety
    • Paranoia
    • Confusion
    • Memory suppression
    Neutral
    • Thought acceleration
    • Time distortion
    • Change in perception
    • Ego softening
    Positive
    • Perception of bodily lightness
    • Visual acuity enhancement
    • Colour enhancement
    • Pattern recognition enhancement
    • Increased music appreciation
    • Brightened colour
    • Enhanced tactile sensation
    Neutral
    • Drifting
    • Internal hallucination
    • Closed/Open eye visuals

    Combinations TripSit

    Cross-Check 25H-NBOMe with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 1 report 1 neutral visit
    Nothing Special neutral exp #102545

    Below is a summary of my experiences with the new RC known as 25H-NBOMe. It is a currently unscheduled alternative to the powerful and popular primary NBOMe series (25i, 25c, 25b). A little about me: Previous psychedelics used: 25I-Nbome, 25B-Nbome, LSD, shrooms, LSA.

    RD · 1 hit buccal / 1 hit buccal / smoked / 1 hit buccal
    25H-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 TripSit 📖 PsychonautWiki