Home
    Disclaimer
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25H-NBOMe

    Aliases: 25h, 2c-h-nbome, Nbome-2c-h, 25-h-nbome

    Psychedelic Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    25H-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-H. Compared with halogenated NBOMes (25I/25C/25B), it shows drastically weaker 5-HT2A potency (approximately 675-fold lower than 25I-NBOMe in vitro) and a pronounced adrenergic/vasoconstrictive profile. Because of low psychedelic potency, users may attempt multi-milligram doses, greatly increasing peripheral toxicity risk (tachycardia, hypertension, vasospasm).

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Sublingual - - - 10mg+(NOTRECOMMENDED)+
    Insufflated - - - 5mg+(NOTRECOMMENDED)+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 15-45 min 30-60 min 1-3 hrs 2-4 hrs 2-6 hrs 3.8-8.8 hrs
    Insufflated 5-15 min 15-30 min 1-3 hrs 2-4 hrs 2-6 hrs 3.3-7.8 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.2
    Moderate+ 5/10

    Strong body load and visuals with moderate headspace

    Visual Intensity ×3
    8
    colour enhancement drifting pattern recognition enhancement brightened colour visual acuity enhancement
    Headspace Depth ×3
    6
    conceptual thinking emotion enhancement confusion time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    10
    vasoconstriction temperature regulation suppression nausea muscle tension increased heart rate
    Stimulant 3.6
    Moderate 4/10

    Strong anxiety/jitters with mild stimulation and focus, low euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    3
    euphoria
    Focus / Productivity ×2
    4
    analysis enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness paranoia increased heart rate vasoconstriction muscle tension
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25H-NBOMe
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 0h Half tolerance 3d Baseline ~14d

    Cross‑tolerance among serotonergic psychedelics is expected due to 5‑HT2A receptor desensitization. Many users report markedly blunted effects if re‑dosing within 1–2 weeks after NBOMe exposure; some describe longer cross‑tolerance windows with higher doses. Data remain anecdotal and variable.

    Cross-Tolerances

    LSD
    60%
    Psilocybin
    60%
    Other NBOMes
    80%
    2C-x
    50%
    DOx
    50%

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Mental/physical stimulation
    Negative
    • Pupil dilation
    • Increased heart rate
    • Increased blood pressure
    • Vasoconstriction
    • Temperature regulation suppression
    • Muscle tension
    • Nausea
    • Restlessness
    • Sweating/chills
    • Insomnia
    Neutral
    • Mouth numbing
    • Decreased appetite
    Positive
    • Analysis enhancement
    • Conceptual thinking
    • Emotion enhancement
    • Wakefulness
    • Euphoria
    • Empathy
    • Insight
    Negative
    • Thought deceleration
    • Anxiety
    • Paranoia
    • Confusion
    • Memory suppression
    Neutral
    • Thought acceleration
    • Time distortion
    • Change in perception
    • Ego softening
    Positive
    • Perception of bodily lightness
    • Visual acuity enhancement
    • Colour enhancement
    • Pattern recognition enhancement
    • Increased music appreciation
    • Brightened colour
    • Enhanced tactile sensation
    Neutral
    • Drifting
    • Internal hallucination
    • Closed/Open eye visuals

    Combinations TripSit

    25H-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki