Below is a summary of my experiences with the new RC known as 25H-NBOMe. It is a currently unscheduled alternative to the powerful and popular primary NBOMe series (25i, 25c, 25b). A little about me: Previous psychedelics used: 25I-Nbome, 25B-Nbome, LSD, shrooms, LSA.
25H-NBOMe
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 25h, 2c-h-nbome, Nbome-2c-h, 25-h-nbome
Summary
25H-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-H. Compared with halogenated NBOMes (25I/25C/25B), it shows drastically weaker 5-HT2A potency (approximately 675-fold lower than 25I-NBOMe in vitro) and a pronounced adrenergic/vasoconstrictive profile. Because of low psychedelic potency, users may attempt multi-milligram doses, greatly increasing peripheral toxicity risk (tachycardia, hypertension, vasospasm).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Sublingual | 1-3mg | 3-6mg | 6-10mg | 10mg+ |
| Insufflated | 0.5-1.5mg | 1.5-3mg | 3-5mg | 5mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Sublingual | 15-45 min | 1-3 hrs | 2-4 hrs | 4-8 hrs |
| Insufflated | - | 1-3 hrs | 2-4 hrs | 4-8 hrs |
Effect Profile
1 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
5.2
Moderate+
5/10
Strong body load and visuals with moderate headspace
Visual Intensity
×3
8
colour enhancement
drifting
pattern recognition enhancement
brightened colour
visual acuity enhancement
Headspace Depth
×3
6
conceptual thinking
emotion enhancement
confusion
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
10
vasoconstriction
temperature regulation suppression
nausea
muscle tension
increased heart rate
Stimulant
3.6
Moderate
4/10
Strong anxiety/jitters with mild stimulation and focus, low euphoria
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
3
euphoria
Focus / Productivity
×2
4
analysis enhancement
thought acceleration
Anxiety / Jitters
×1
10
anxiety
restlessness
paranoia
increased heart rate
vasoconstriction
muscle tension
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Tolerance Decay
Half tolerance
7d
Baseline
~14d
Cross‑tolerance among serotonergic psychedelics is expected due to 5‑HT2A receptor desensitization. Many users report markedly blunted effects if re‑dosing within 1–2 weeks after NBOMe exposure; some describe longer cross‑tolerance windows with higher doses. Data remain anecdotal and variable.
Cross-Tolerances
Effects
Positive
- Stimulation
- Mental/physical stimulation
Negative
- Pupil dilation
- Increased heart rate
- Increased blood pressure
- Vasoconstriction
- Temperature regulation suppression
- Muscle tension
- Nausea
- Restlessness
- Sweating/chills
- Insomnia
- Mouth numbing
- Decreased appetite
Positive
- Analysis enhancement
- Conceptual thinking
- Emotion enhancement
- Wakefulness
- Euphoria
- Empathy
- Insight
Negative
- Thought deceleration
- Anxiety
- Paranoia
- Confusion
- Memory suppression
- Thought acceleration
- Time distortion
- Change in perception
- Ego softening
Positive
- Perception of bodily lightness
- Visual acuity enhancement
- Colour enhancement
- Pattern recognition enhancement
- Increased music appreciation
- Brightened colour
- Enhanced tactile sensation
- Drifting
- Internal hallucination
- Closed/Open eye visuals
Combinations
Cross-Check 25H-NBOMe with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 1 report 1 neutral visit
25H-NBOMe's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 25H-NBOMe? Let us know. Reports are reviewed by moderators — this is not posted publicly.