Wednesday, March 10, 2004 2,5-dimethoxy-4-methylphenethylamine (2C-D, LE-25) Here we go again. I am a guinea pig playing with an obscure psychedelic drug research chemical. But don't get me wrong, I find it very exciting; and love to discover new properties in psychedelic drugs.
2C-D
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 6 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 6 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: 2c-m, Le-25, 2cd, 2cm
Summary
2,5-Dimethoxy-4-methylphenethylamine (also known as 2C-M, LE-25 and more commonly as 2C-D) is a synthetic psychedelic of the phenethylamine chemical class that produces short-lived psychedelic effects when administered. Its sensory and cognitive effects profile has been described as being the most similar to that of mescaline among members of the 2C-x family, albeit with a significantly shorter duration. The synthesis of 2C-D was first published in 1970 by a team from the Texas Research Institute of Mental Sciences.
Perspectives
“There were two noteworthy things about this experience. The first was how instantly and intensely painful snorting the chemical was, more so than other 2Cβs Iβve dosed intranasally. The second was how short it was- it was fast, intense, pretty uncomfortable, but passed into nothing fairly quickly. Overall it felt very standard and inconsequential, just a brief foray into psychedelia with somewhat standard visuals.”
“There is something going on, but it is subtle. I find that I can just slightly redirect my attention so that it applies more exactly to what I am doing. I feel that I can learn faster. This is a βsmartβ pill!”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-25mg | 25-50mg | 50-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 19-40 min | 1.5-2.5 hrs | 30-90 min | 3.5-5 hrs |
| Insufflated | 4-15 min | 15-30 min | 1.5-2.5 hrs | 30-90 min | 3-5 hrs |
Effect Profile
72 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 72 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.8
Intense+
9/10
Strong visuals, headspace, auditory effects, and body load
Visual Intensity
×3
10
external hallucinations
internal hallucinations
color enhancement
autonomous entities
drifting
synaesthesia
+7 more
Headspace Depth
×3
10
conceptual thinking
thought connectivity
introspection
recursion
emotion enhancement
perspective alterations
+2 more
Auditory Effects
×1
10
auditory distortion
auditory enhancement
auditory hallucinations
auditory hallucination
synaesthesia
Body Load / Somatic Effects
×1
10
nausea
temperature regulation suppression
stomach discomfort
increased heart rate
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has 2C-D, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "2C-D (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Dose & duration (reference)
2C-D: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Insufflated dose (mg): threshold 1 Insufflated duration: onset 4-15m Β· come-up 15-30m Β· peak 1.5-2.5h Β· offset 0.5-1.5h Β· total 3-5h Β· after-effects 1-4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops rapidly after a single use
Reset
7β14 days for baseline
Tolerance Decay
Full tolerance
1d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Classic psychedelics exhibit rapid tolerance and crossβtolerance mediated by 5βHT2A signaling; typical advice is spacing experiences by 1β2 weeks for a βfreshβ response. Data are synthesized from historical and userβreported sources; formal human PK/PD tolerance studies for 2CβD are lacking.
Cross-Tolerances
Effects
Aggregated from 72 Erowid experience reports
Positive Effects 10
Color Enhancement
55.6%
70%
Stimulation
55.6%
70%
Tactile Enhancement
47.2%
70%
Music Enhancement
40.3%
70%
Empathy
38.9%
70%
Focus Enhancement
33.3%
70%
Euphoria
33.3%
70%
Introspection
29.2%
70%
Body High
22.2%
70%
Creativity Enhancement
13.9%
70%
Adverse Effects 10
Anxiety
50.0%
70%
Confusion
33.3%
70%
Nausea
29.2%
70%
Muscle Tension
20.8%
70%
Headache
19.4%
70%
Increased Heart Rate
13.9%
70%
Pupil Dilation
13.9%
70%
Sweating
8.3%
70%
Memory Suppression
8.3%
70%
Jaw Clenching
4.2%
70%
Combinations
Cross-Check 2C-D with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 1 positive 6 neutral 1 cautionary visit
Yesterday was my first experience with 2C-D. I have had prior experience with phenethylamines, such as 2C-I (toxic reaction), mescaline (wonderful, enlightening), Methylone , MDMA, and of course a host of tryptamines as well.
First a little background info about me. I am an experienced MDMA user for about 15 years now (wow, time is running...) and had so far only one psychedelic experience with magic mushrooms which I enjoyed but rather donΒt want to do again. Other than that I tried amphetamines and cocaine several times.
Revealing Tofu's Inner Light by Xorkoth The following is a compilation of my first two 2C-D trips at psychedelic levels. Trial #1 6-8-2019 - 35mg oral + 15mg booster at T+1 hour I didn't take any notes at the time for this trip so this is from memory (though it's been less than a week).
Last night I finally got to try the only phenethylamine that I still really had much interest in, 2C-D. I had nothing better to do and I asked two of my friends, J and K if they were down with tripping. I had only one 40mg dose of 2C-D saved and I had dibs on that.
December 16, 2006 50 milligrams of 2,5-dimethoxy-4-methylphenethylamine Prologue: Forgive me in advance dedicated readers for the brevity in this report, and lack of juicy details.
Substance: 2C-D HCl (2,5-dimethoxy-4-methylphenethylamine hydrochloride) Dosage: 30 mg, p.o., dissolved in water Age: mid 20s Weight: ~ 60 kg Intention: "psychedelic recalibration", having a nice hike, exploring the space of 2C-D further, search for direction in life.
Rapid onset with first alert felt at around T+4 or 5 minutes, rapidly elevating in intensity--an overwhelming psychedelic body rush. It is too much for me, I vomit from the intensity, then go lie down. I am enveloped by geometric shapes.
Bluelight 8 threads 7 neutral 1 cautionary visit
2CD - fifth time - wonderful thinking, wish it would last Had the day off. Some interesting intellectual work to do - writing about photographs - and a beautiful day outside and I thought I might garden. Had decided to take day off "sick". Woke up 7:30am or so. Got up read newspaper.
Wednesday, March 10, 2004 40mg of 2,5-dimethoxy-4-methylphenethylamine (2C-D, LE-25) Here we go again. I am a guinea pig playing with an obscure psychedelic drug research chemical. But donβt get me wrong, I find it very exciting; and love to discover new properties in psychedelic drugs.
Revealing Tofu's Inner Light by Xorkoth The following is a compilation of my first two 2C-D trips at psychedelic levels. Trial #1 6-8-2019 - 35mg oral + 15mg booster at T+1 hour β I didn't take any notes at the time for this trip so this is from memory (though it's been less than a week).
2C-D, First Two Times, Unique and Impressive as a Study Aid Well, I figured it's about time that I contribute a trip report here. Trip reports aren't really my thing, but there is precious little information about using 2C-D as a study aid (I find "smart drug" very misleading) so I figured I'd share my two experiences....
12/16/2006 50 milligrams of 2,5-dimethoxy-4-methylphenethylamine Prologue: Forgive me in advance dedicated readers for the brevity in this report, and lack of juicy details.
Substance: 2C-D HCl (2,5-dimethoxy-4-methylphenethylamine hydrochloride) Dosage: 30 mg, p.o., dissolved in water Age: mid 20s Weight: ~ 60 kg Intention: "psychedelic recalibration", having a nice hike, exploring the space of 2C-D further, search for direction in life.
2C-D - 2nd time - Much stronger then imagined! This is my first trip report so forgive me if I donβt do a good job. I got hold of some 2C-D not too long ago, and decided I would try some by my self just to see what is the nature of this molecule.
This is an account of the first time I did 2c-d. It was in July of this year. I never really got around to writing a report about it but I decided I probably should to warn people about the experience that me and my friend had with this compound.
Bluelight Reference Guide
Phenethylamines The Big & Dandy 2C-D Thread - Please Insert Second Disc
Welcome to the Big & Dandy 2C-D Thread (Part 2) External Information Links: Erowid 2C-D Vault (experience reports) 2C-D as a Smart Drug PIHKAL Entry on 2C-D Wikipedia entry Previous Big & Dandy Threads: Thread 1 [some posts from the previous thread:] twelvesevndi said: are you saying that because you've tried 2C-E and...
Read full thread on Bluelight βPiHKAL / TiHKAL
PiHKAL #23: 2C-D
“There is something going on, but it is subtle. I find that I can just slightly redirect my attention so that it applies more exactly to what I am doing. I feel that I can learn faster. This is a βsmartβ pill!”
2C-D's nerd page
Pharmacology, chemical data, effect profiles, and more
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