2C-D
Aliases: 2c-m, Le-25, 2cd, 2cm
Summary
2,5-Dimethoxy-4-methylphenethylamine (also known as 2C-M, LE-25 and more commonly as 2C-D) is a synthetic psychedelic of the phenethylamine chemical class that produces short-lived psychedelic effects when administered. Its sensory and cognitive effects profile has been described as being the most similar to that of mescaline among members of the 2C-x family, albeit with a significantly shorter duration. The synthesis of 2C-D was first published in 1970 by a team from the Texas Research Institute of Mental Sciences.
Perspectives
“There were two noteworthy things about this experience: how instantly and intensely painful snorting the chemical was, and how short it was—fast, intense, pretty uncomfortable, but passed into nothing fairly quickly. Overall it felt very standard and inconsequential.”
“There is something going on, but it is subtle. I find that I can just slightly redirect my attention so that it applies more exactly to what I am doing. I feel that I can learn faster. This is a ‘smart’ pill!”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-25mg | 25-50mg | 50-100mg | 100mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 19-40 min | 1.5-2.5 hrs | 30-90 min | 3.5-5 hrs |
| Insufflated | 4-15 min | 15-30 min | 1.5-2.5 hrs | 30-90 min | 3-5 hrs |
Effect Profile
72 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 72 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals, headspace, auditory effects, and body load
Tolerance
Tolerance Decay
Classic psychedelics exhibit rapid tolerance and cross‑tolerance mediated by 5‑HT2A signaling; typical advice is spacing experiences by 1–2 weeks for a ‘fresh’ response. Data are synthesized from historical and user‑reported sources; formal human PK/PD tolerance studies for 2C‑D are lacking.
Cross-Tolerances
Effects
Aggregated from 72 Erowid experience reports
Positive Effects 10
Adverse Effects 10
Combinations
Trip Reports
PiHKAL / TiHKAL
“There is something going on, but it is subtle. I find that I can just slightly redirect my attention so that it applies more exactly to what I am doing. I feel that I can learn faster. This is a ‘smart’ pill!”