Preface: 3-Me-PCPy is an exciting development in the world of Arylcyclohexylamines! Once again IΒll give a brief chemistry/pharmacology primer to contextualize this drug, if thatΒs not of interest, just skip to the body of the report. And per usual, there is an overall summary of the compound at the end.
3-Me-PCPy
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
Aliases: M3ppy, Tolicyclidine
Summary
3-Me-PCPy (3-Methylrolicyclidine, also called Tolicyclidine) is the 3-methyl analogue of rolicyclidine (PCPy). Receptor binding studies show high affinity for the NMDA receptor (Ki β39 nM) while simultaneously acting as a potent triple reuptake inhibitor at DAT, NET, and SERT (Ki 5.6-52 nM), a unique pharmacological profile not shared by most arylcyclohexylamines. This combination produces pronounced stimulation alongside dissociation.
Perspectives
“If I had to describe 3-Me-PCPy as anything I would call it dissociative cocaine. It is short, fast, fun, stimulating, euphoric, hedonistic, reinforcing, and low-commitment.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-30mg | 30mg+ |
| Insufflated | 5-10mg | 10-20mg | 20-25mg | 25mg+ |
| Smoked | 5-10mg | 10-20mg | 20-25mg | 25mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 0.75-2 hrs | 2-3 hrs | 1-2 hrs | 4-8 hrs |
| Insufflated | 5-30 min | 45-90 min | 1.5-2 hrs | 45-60 min | 3-5 hrs |
| Rectal | 3-15 min | 19-40 min | 1-2 hrs | 1-2 hrs | - |
| Smoked | 0-3 min | 4-15 min | 30-90 min | 1-2 hrs | 0.75-2 hrs |
Effect Profile
4 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
4.3
Moderate
4/10
Strong dissociative depth, mania, and motor impairment
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
visual disconnection
spatial disorientation
Mania / Compulsion
×1
10
mania
compulsive redosing
delusions
disinhibition
stimulation
Insight / Novel Thought
×2
0
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
Stimulant
3.6
Moderate
4/10
Moderate euphoria with low stimulation and anxiety/jitters
Stimulation / Energy
×3
3
stimulation
Euphoria / Mood Lift
×2
6
physical euphoria
cognitive euphoria
Focus / Productivity
×2
0
Anxiety / Jitters
×1
2
increased heart rate
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2β4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
14d
Baseline
~28d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Anecdotal dissociative tolerance builds within 1β2 days of repeated exposure and decays over about 1β2 weeks; stimulant-like tolerance may build/resolve faster. Data derived from user reports of ACHs; no controlled studies.
Cross-Tolerances
Effects
Aggregated from 4 Erowid experience reports
Positive Effects 4
Euphoria
100.0%
70%
Stimulation
100.0%
70%
Focus Enhancement
75.0%
70%
Tactile Enhancement
75.0%
70%
Adverse Effects 1
Confusion
75.0%
70%
Combinations
Cross-Check 3-Me-PCPy with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 3 reports 3 neutral visit
1 gram of Tolicyclidine HCl (3-methylrolicyclidine, 3-Me-PCPy) found its way my way. I've quit drugs (last dose 2019) so the plan is, one session, discard the rest. I may use the leftovers to more precisely establish water solubility.
Making myself comfortable with the substance. 3-Me-PCPy comes as slightly off white, grainy cystalline powder. First time consuming 3-Me-PCPy. Potential tolerance: 3 Days prior I had taken a moderate amount of Ketamine. hh:mm t+ 00:00 5 mg insufflated. Very strong caustic burn.
Bluelight Reference Guide
Dissociatives The Small & Handy 3-Me-PCPy thread
Oh yay I get to start one of these myself finally An interesting arylcyclohexylamine that is purported to be hitting the markets soon PCPy analogues haven't really been seen on the online rc market- 3-MeO-PCPy existed for a bit long ago but not too much information on it came out.
Read full thread on Bluelight β
3-Me-PCPy's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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