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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-Me-PCPy

    Aliases: M3ppy, Tolicyclidine

    Dissociative Stimulant Research-chemical

    Summary TheDrug.Wiki

    3-Me-PCPy (3-Methylrolicyclidine, also called Tolicyclidine) is the 3-methyl analogue of rolicyclidine (PCPy). Receptor binding studies show high affinity for the NMDA receptor (Ki ≈39 nM) while simultaneously acting as a potent triple reuptake inhibitor at DAT, NET, and SERT (Ki 5.6-52 nM), a unique pharmacological profile not shared by most arylcyclohexylamines. This combination produces pronounced stimulation alongside dissociation.

    Perspectives

    “If I had to describe 3-Me-PCPy as anything I would call it dissociative cocaine. It is short, fast, fun, stimulating, euphoric, hedonistic, reinforcing, and low-commitment.”

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-45 min 30-60 min 1-2 hrs 1-2 hrs 1-6 hrs
    Insufflated 4-19 min 19-45 min 1-2 hrs 1-2 hrs 1-6 hrs
    Rectal 3-15 min 19-40 min 1-2 hrs 1-2 hrs 1-6 hrs
    Smoked 0-3 min 4-15 min 30-90 min 1-2 hrs 1-6 hrs

    Effect Profile

    4 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 4.3
    Moderate 4/10

    Strong dissociative depth, mania, and motor impairment

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection visual disconnection spatial disorientation
    ⚠ Mania / Compulsion ×1
    10
    mania compulsive redosing delusions disinhibition stimulation
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection
    Stimulant 3.6
    Moderate 4/10

    Moderate euphoria with low stimulation and anxiety/jitters

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    6
    physical euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    2
    increased heart rate
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 3-Me-PCPy
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 1d Half tolerance 3d Baseline ~10d

    Anecdotal dissociative tolerance builds within 1–2 days of repeated exposure and decays over about 1–2 weeks; stimulant-like tolerance may build/resolve faster. Data derived from user reports of ACHs; no controlled studies.

    Cross-Tolerances

    3-MeO-PCP
    60%
    3-MeO-PCE
    60%
    ketamine-class dissociatives
    50%

    Effects Erowid

    Aggregated from 4 Erowid experience reports

    Positive Effects 4

    Euphoria 100.0% 70%
    Stimulation 100.0% 70%
    Focus Enhancement 75.0% 70%
    Tactile Enhancement 75.0% 70%

    Adverse Effects 1

    Confusion 75.0% 70%

    Combinations TripSit

    3-Me-PCPy's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 Bluelight 📖 PsychonautWiki