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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-Me-PCPy Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical

    Aliases: M3ppy, Tolicyclidine

    Dissociative Stimulant Research-chemical

    Summary dose.wiki

    3-Me-PCPy (3-Methylrolicyclidine, also called Tolicyclidine) is the 3-methyl analogue of rolicyclidine (PCPy). Receptor binding studies show high affinity for the NMDA receptor (Ki β‰ˆ39 nM) while simultaneously acting as a potent triple reuptake inhibitor at DAT, NET, and SERT (Ki 5.6-52 nM), a unique pharmacological profile not shared by most arylcyclohexylamines. This combination produces pronounced stimulation alongside dissociation.

    Perspectives

    “If I had to describe 3-Me-PCPy as anything I would call it dissociative cocaine. And this isn’t just because it supposedly shares a portion of its pharmacology with cocaine. It is short, fast, fun, stimulating, euphoric, hedonistic, reinforcing, and low-commitment.”

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-20mg 20-30mg 30mg+
    Insufflated 5-10mg 10-20mg 20-25mg 25mg+
    Smoked 5-10mg 10-20mg 20-25mg 25mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-90 min 0.75-2 hrs 2-3 hrs 1-2 hrs 4-48 hrs 4-8 hrs
    Insufflated 5-30 min 45-90 min 1.5-2 hrs 45-60 min 4-48 hrs 3-5 hrs
    Rectal 3-15 min 19-40 min 1-2 hrs 1-2 hrs 1-6 hrs 2.37-4.92 hrs
    Smoked 0-3 min 4-15 min 30-90 min 1-2 hrs 1-6 hrs 0.75-2 hrs

    Effect Profile

    4 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 4.3
    Moderate 4/10

    Strong dissociative depth, mania, and motor impairment

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection visual disconnection spatial disorientation
    ⚠ Mania / Compulsion ×1
    10
    mania compulsive redosing delusions disinhibition stimulation
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection
    Stimulant 3.6
    Moderate 4/10

    Moderate euphoria with low stimulation and anxiety/jitters

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    6
    physical euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    2
    increased heart rate
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 3-Me-PCPy
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3-Me-PCPy there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "3-Me-PCPy (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    3-Me-PCPy
    Unit
    mg
    Description 
    3-Me-PCPy
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5 Β· light 5-10 Β· common 10-20 Β· strong 20-30 Β· heavy 30+
Insufflated dose (mg): threshold 5 Β· light 5-10 Β· common 10-20 Β· strong 20-25 Β· heavy 25+
Rectal dose (mg): threshold 1
Smoked dose (mg): threshold 2 Β· light 5-10 Β· common 10-20 Β· strong 20-25 Β· heavy 25+

Oral duration: onset 0.5-1.5h Β· come-up 0.75-2h Β· peak 2-3h Β· offset 1-2h Β· total 4-8h Β· after-effects 4-48h
Insufflated duration: onset 5-30m Β· come-up 0.75-1.5h Β· peak 1.5-2h Β· offset 0.75-1h Β· total 3-5h Β· after-effects 4-48h
Rectal duration: onset 3-15m Β· come-up 19-40m Β· peak 1-2h Β· offset 1-2h Β· total 2.37-4.92h Β· after-effects 1-6h
Smoked duration: onset 0-3m Β· come-up 4-15m Β· peak 0.5-1.5h Β· offset 1-2h Β· total 0.75-2h Β· after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 1d Half tolerance 14d Baseline ~28d

    Anecdotal dissociative tolerance builds within 1–2 days of repeated exposure and decays over about 1–2 weeks; stimulant-like tolerance may build/resolve faster. Data derived from user reports of ACHs; no controlled studies.

    Cross-Tolerances

    3-MeO-PCP
    60%
    3-MeO-PCE
    60%
    ketamine-class dissociatives
    50%

    Effects Erowid

    Aggregated from 4 Erowid experience reports

    Positive Effects 4

    Euphoria 100.0% 70%
    Stimulation 100.0% 70%
    Focus Enhancement 75.0% 70%
    Tactile Enhancement 75.0% 70%

    Adverse Effects 1

    Confusion 75.0% 70%

    Combinations

    Cross-Check 3-Me-PCPy with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 3 reports 3 neutral visit
    Revelers Fire neutral exp #115645

    Preface: 3-Me-PCPy is an exciting development in the world of Arylcyclohexylamines! Once again IΒ’ll give a brief chemistry/pharmacology primer to contextualize this drug, if thatΒ’s not of interest, just skip to the body of the report. And per usual, there is an overall summary of the compound at the end.

    nervewing · 20 mg insufflated
    Taking Two for the Team neutral exp #115504

    1 gram of Tolicyclidine HCl (3-methylrolicyclidine, 3-Me-PCPy) found its way my way. I've quit drugs (last dose 2019) so the plan is, one session, discard the rest. I may use the leftovers to more precisely establish water solubility.

    Asante · 5 mg rectal / 5 mg rectal
    Low Dose Explorations neutral exp #118619

    Making myself comfortable with the substance. 3-Me-PCPy comes as slightly off white, grainy cystalline powder. First time consuming 3-Me-PCPy. Potential tolerance: 3 Days prior I had taken a moderate amount of Ketamine. hh:mm t+ 00:00 5 mg insufflated. Very strong caustic burn.

    Zirconium · 5 - 10 mg insufflated

    Bluelight Reference Guide Bluelight

    Dissociatives The Small & Handy 3-Me-PCPy thread

    Oh yay I get to start one of these myself finally An interesting arylcyclohexylamine that is purported to be hitting the markets soon PCPy analogues haven't really been seen on the online rc market- 3-MeO-PCPy existed for a bit long ago but not too much information on it came out.

    Read full thread on Bluelight β†’
    3-Me-PCPy's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    πŸ“˜ Experience Reports πŸ“– dose.wiki πŸ“– Bluelight πŸ“– PsychonautWiki