Summary
3-Me-PCPy (3-Methylrolicyclidine, also called Tolicyclidine) is the 3-methyl analogue of rolicyclidine (PCPy). Receptor binding studies show high affinity for the NMDA receptor (Ki ≈39 nM) while simultaneously acting as a potent triple reuptake inhibitor at DAT, NET, and SERT (Ki 5.6-52 nM), a unique pharmacological profile not shared by most arylcyclohexylamines. This combination produces pronounced stimulation alongside dissociation. Reports describe lucid, often manic psychostimulation with euphoria, pressured thought, and elevated cardiovascular parameters. The compound is exceptionally caustic when insufflated.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 1.0-2.0 hrs | 1.0-2.0 hrs | 1.0-6.0 hrs |
| Insufflated | 4-19 min | 19-45 min | 1.0-2.0 hrs | 1.0-2.0 hrs | 1.0-6.0 hrs |
| Rectal | 3-15 min | 19-40 min | 1.0-2.0 hrs | 1.0-2.0 hrs | 1.0-6.0 hrs |
| Smoked | 0-3 min | 4-15 min | 30-90 min | 1.0-2.0 hrs | 1.0-6.0 hrs |
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Cross-tolerance
Effects
Positive
- Physical euphoria
- Stimulation
Negative
- Increased heart rate
- Increased blood pressure
- Nystagmus
- Insomnia
- Numbness
- Loss of balance
- Physical disconnection
- Sedation
Positive
- Cognitive euphoria
- Anxiety suppression
Negative
- Depersonalization
- Derealization
- Compulsive redosing
- Mania
- Delusions
- Motor control loss
- Dissociation
- Time distortion
Positive
- Tactile enhancement
- Increased music appreciation
- Auditory enhancement
- Increased libido
Negative
- Disinhibition
- Tactile suppression
- Spatial disorientation
- Dehydration
- Visual distortion
- Visual disconnection
- Auditory distortion