Summary
3C-E is the Ξ±-methyl homologue of escaline and sits pharmacologically between the 2C-series and the longer-acting DOx family. Street material has ranged from fluffy white powder to off-white crystals β always verify identity with Marquis/Mecke reagents and, ideally, FT-IR or GC-MS. Most users describe a 'bimodal' experience: colourful mescaline-like visuals and empathic warmth alongside noticeable peripheral stimulation (jaw tension, sweating, mild hypertension). Body-load is highly dose-dependent; doses β₯50 mg frequently produce tachycardia, nausea or vascular tightness. Start low, dose once, stay hydrated, and allocate 12-16 hours without responsibilities.
Perspectives
“It developed into a strange and indefinable something. It is unworldly. I am very much in control, but with an undertone of unreality that is a little reminiscent of high doses of LSD. If there were a great deal of sensory input, I might not see it. And if I were in complete sensory quiet I would miss it, too. But just where I am, I can see it. Eerie state of awareness. And by the 8th hour I am sober, with no residue except for some slight teeth clenching, and pretty much disbelieving the whole thing.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-40mg | 40-60mg | 60-80mg | 80mg+ |
| Insufflated | 20-35mg | 35-60mg | 60-70mg | 70mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 1-2 hrs | 30-90 min | 4-8 hrs | 3-6 hrs | 3-6 hrs | 480-0 min |
| Insufflated | 5-90 min | 20-60 min | 4-7 hrs | 2-5 hrs | 3-5 hrs | 480-0 min |
Tolerance
Effects
- Stimulation
- Physical Euphoria
- Mental/physical stimulation
- Nausea
- Increased Blood Pressure
- Increased Heart Rate
- Increased Perspiration
- Dry Mouth
- Temperature Regulation Suppression
- Teeth Grinding
- Pupil Dilation
- Vasoconstriction
- Restlessness
- Sweating/chills
- Muscle tension
- Insomnia
- Seizure
- Diarrhea
- Muscle twitching
- Muscle Contractions
- Difficulty Urinating
- Decreased appetite
- Spontaneous bodily sensations
- Increased salivation
- Brightness alteration
- Conceptual Thinking
- Thought Connectivity
- Analysis Enhancement
- Cognitive Euphoria
- Empathy Enhancement
- Emotion Enhancement
- Wakefulness
- Immersion Enhancement
- Euphoria
- Empathy
- Insight
- Empathy, affection and sociability enhancement
- Novelty enhancement
- Unity and interconnectedness
- Laughter fits
- Increased sense of humor
- Immersion intensification
- Memory Suppression
- Confusion
- Anxiety
- Paranoia
- Depth Perception Distortions
- Perspective Distortions
- Thought Acceleration
- Time Distortion
- Change in perception
- Ego softening
- Perspective distortion
- Personal bias suppression
- Existential self-realization
- Emotion intensification
- Bodily Control Enhancement
- Tactile Enhancement
- Colour Enhancement
- Pattern Recognition Enhancement
- Visual Acuity Enhancement
- Colour Shifting
- Tracers
- Increased Music Appreciation
- Synaesthesia
- Brightened colour
- Enhanced tactile sensation
- Increased libido
- Color enhancement
- Color shifting
- Auditory acuity enhancement
- Appetite Suppression
- Dehydration
- Spontaneous Physical Sensations
- Drifting
- Symmetrical Texture Repetition
- After Images
- Diffraction
- Internal Hallucinations
- Closed/Open eye visuals
- Auditory hallucination
- Auditory distortion
- Internal hallucination
- Autonomous entity
- Perspective hallucination
- Tactile intensification
Combinations
Trip Reports
PiHKAL / TiHKAL
“It developed into a strange and indefinable something. It is unworldly. I am very much in control, but with an undertone of unreality that is a little reminiscent of high doses of LSD. If there were a great deal of sensory input, I might not see it. And if I were in complete sensory quiet I would miss it, too. But just where I am, I can see it. Eerie state of awareness. And by the 8th hour I am sober, with no residue except for some slight teeth clenching, and pretty much disbelieving the whole thing.”