3C-E
Aliases: 3c-escaline
Summary
3,5-Dimethoxy-4-ethoxyamphetamine (commonly known as 3C-E or 3C-Escaline) is a synthetic psychedelic compound of the amphetamine chemical class. Although it's name suggests it may be related to the 2C-x family, this is not the case. 3C-E has the structure of escaline, a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.
Perspectives
“This is certainly one of the most physically stimulating psychedelics I have taken, with the physical effects long outlasting any of the other effects. The nausea and stomach cramps were definitely prominent throughout the experience. There did not seem to be any empathogenic effects.”
“It developed into a strange and indefinable something. It is unworldly. I am very much in control, but with an undertone of unreality that is a little reminiscent of high doses of LSD. If there were a great deal of sensory input, I might not see it. And if I were in complete sensory quiet I would miss it, too. But just where I am, I can see it. Eerie state of awareness. And by the 8th hour I am sober, with no residue except for some slight teeth clenching, and pretty much disbelieving the whole thing.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-40mg | 40-60mg | 60-80mg | 80mg+ |
| Insufflated | 20-35mg | 35-60mg | 60-70mg | 70mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 30-90 min | 4-8 hrs | 3-6 hrs | 8.5-17.5 hrs |
| Insufflated | 5-90 min | 20-60 min | 4-7 hrs | 2-5 hrs | 6.4-14.5 hrs |
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals, headspace, auditory effects, and body load
Strong anxiety/jitters and euphoria with mild stimulation and focus
Tolerance
Tolerance Decay
Rapid, session‑immediate tolerance typical of serotonergic psychedelics; partial cross‑tolerance expected across classical psychedelics and psychedelic amphetamines. Values are heuristic and based on community practice (space 2–3 weeks between full experiences).
Cross-Tolerances
Effects
Aggregated from 3 Erowid experience reports
Positive Effects 2
Adverse Effects 1
Combinations
Trip Reports
PiHKAL / TiHKAL
“It developed into a strange and indefinable something. It is unworldly. I am very much in control, but with an undertone of unreality that is a little reminiscent of high doses of LSD. If there were a great deal of sensory input, I might not see it. And if I were in complete sensory quiet I would miss it, too. But just where I am, I can see it. Eerie state of awareness. And by the 8th hour I am sober, with no residue except for some slight teeth clenching, and pretty much disbelieving the whole thing.”