*Through this report,* I consume a total of 65-70mg of 3C-E insufflated until the very last 20mg-25mg which was taken orally. It measured out at either 30mg or 15mg and split into little bumps to avoid burn or discomfort. I am a 22 yr old male, I am out of shape but dieting recently. I weigh about 275lbs.
3C-E
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 20 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 20 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Aliases: 3c-escaline
Summary
3,5-Dimethoxy-4-ethoxyamphetamine (commonly known as 3C-E or 3C-Escaline) is a synthetic psychedelic compound of the amphetamine chemical class. Although it's name suggests it may be related to the 2C-x family, this is not the case. 3C-E has the structure of escaline, a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.
Perspectives
“This is certainly one of the most physically stimulating psychedelics I have taken, with the physical effects long outlasting any of the other effects. The nausea and stomach cramps were definitely prominent throughout the experience. There did not seem to be any empathogenic effects.”
“It developed into a strange and indefinable something. It is unworldly. I am very much in control, but with an undertone of unreality that is a little reminiscent of high doses of LSD. If there were a great deal of sensory input, I might not see it. And if I were in complete sensory quiet I would miss it, too. But just where I am, I can see it. Eerie state of awareness. And by the 8th hour I am sober, with no residue except for some slight teeth clenching, and pretty much disbelieving the whole thing.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-40mg | 40-60mg | 60-80mg | 80mg+ |
| Insufflated | 20-35mg | 35-60mg | 60-70mg | 70mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 30-90 min | 4-8 hrs | 3-6 hrs | 8-14 hrs |
| Insufflated | 5-90 min | 20-60 min | 4-7 hrs | 2-5 hrs | 8-14 hrs |
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.8
Intense+
9/10
Strong visuals, headspace, auditory effects, and body load
Visual Intensity
×3
10
internal hallucinations
colour enhancement
drifting
tracers
synaesthesia
pattern recognition enhancement
+6 more
Headspace Depth
×3
10
conceptual thinking
thought connectivity
emotion enhancement
perspective distortions
personal bias suppression
time distortion
+1 more
Auditory Effects
×1
10
auditory distortion
auditory hallucination
synaesthesia
Body Load / Somatic Effects
×1
10
nausea
temperature regulation suppression
vasoconstriction
muscle tension
teeth grinding
increased heart rate
Stimulant
5.1
Moderate+
5/10
Strong anxiety/jitters and euphoria with mild stimulation and focus
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
9
physical euphoria
cognitive euphoria
euphoria
Focus / Productivity
×2
4
analysis enhancement
thought acceleration
Anxiety / Jitters
×1
10
anxiety
restlessness
paranoia
increased heart rate
teeth grinding
vasoconstriction
+1 more
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Half tolerance
7d
Baseline
~14d
Rapid, session‑immediate tolerance typical of serotonergic psychedelics; partial cross‑tolerance expected across classical psychedelics and psychedelic amphetamines. Values are heuristic and based on community practice (space 2–3 weeks between full experiences).
Cross-Tolerances
Effects
Aggregated from 3 Erowid experience reports
Positive Effects 2
Color Enhancement
100.0%
70%
Music Enhancement
100.0%
70%
Adverse Effects 1
Nausea
100.0%
70%
Combinations
Cross-Check 3C-E with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 1 report 1 neutral visit
Bluelight 3 threads 3 neutral visit
Age: 21 Weight: 120 lbs Dosage: 50 mg oral in gel cap Setting: My apartment T0:00-Dose taken. At my house with friends over, two of them on acid and one of a combination of MXP and DXM. T0:20-First notes begin to manifest, a bit of chills and shaking with some abdominal discomfort.
Background: I'm middle aged and have taken several dozen classical and research psychedelics over the last few decades. Set: I shouldn't have any psychedelic tolerance at the moment, since it's been several weeks since my last experience. I've been on a course of memantine.
3C-E - 3rd Time - ~17mg semi-sublingually NOTE ON DOSAGE: So the dose could be quite a bit off here. The scale was acting up, but all measurments taken were between 11-17mg. The final several measurements hovered between 16-17mg, though. SETTING: It was a beautiful, cool, crisp fall morning.
PiHKAL / TiHKAL
PiHKAL #25: 3C-E
“It developed into a strange and indefinable something. It is unworldly. I am very much in control, but with an undertone of unreality that is a little reminiscent of high doses of LSD. If there were a great deal of sensory input, I might not see it. And if I were in complete sensory quiet I would miss it, too. But just where I am, I can see it. Eerie state of awareness. And by the 8th hour I am sober, with no residue except for some slight teeth clenching, and pretty much disbelieving the whole thing.”
3C-E's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 3C-E? Let us know. Reports are reviewed by moderators — this is not posted publicly.