Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    5-APDI

    Aliases: Iap, 2-api, 5-iap, Indanametamine, Indanylamphetamine

    Psychedelic Stimulant Empathogen Research-chemical

    Summary TheDrug.Wiki Erowid TripSit

    5-APDI (IAP) is a potent but weakly selective serotonin-releasing agent with IC50 values of 82 nM for serotonin, 1,848 nM for dopamine, and 849 nM for norepinephrine. Users report empathogenic warmth, mental stimulation, and occasionally mild visuals, but also pronounced body-load including hyperthermia, profuse sweating, bowel urgency, bruxism, and insomnia. Onset is slow; premature redosing has produced serotonin syndrome-like reactions.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 15-25mg 25-50mg 50-75mg 75mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects
    Oral 30-90 min 2-5 hrs 3-6 hrs 1-6 hrs
    Insufflated 5-15 min 2-4 hrs 2-4 hrs 1-6 hrs
    Intravenous 1-5 min 2-4 hrs 2-4 hrs 1-6 hrs

    Effect Profile

    16 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 2.5
    Light 2/10

    Mild auditory effects with low visuals and body load

    Visual Intensity ×3
    3
    tracers visual enhancement
    Headspace Depth ×3
    0
    Auditory Effects ×1
    4
    music enhancement
    ⚠ Body Load / Somatic Effects ×1
    3
    teeth grinding sweating
    Empathogen 5.1
    Moderate+ 5/10

    Moderate stimulation with mild empathy, euphoria, and sensory enhancement

    Empathy / Social Openness ×3
    5
    empathy enhancement increased sociability
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    6
    stimulation wakefulness teeth grinding
    Sensory Enhancement ×1
    5
    music enhancement visual enhancement
    Stimulant 3.5
    Moderate 4/10

    Moderate anxiety/jitters with mild stimulation and euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    5
    euphoria mood lift
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    7
    anxiety teeth grinding sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 5-APDI
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~21d

    Rapid acute tolerance is frequently reported with SRAs; spacing of several weeks is prudent by analogy to MDMA. Estimates are heuristic and based on anecdotal patterns rather than formal PK/PD studies.

    Cross-Tolerances

    MDMA
    60%
    MDA
    60%
    Other serotonergic empathogens
    50%

    Effects Erowid

    Aggregated from 16 Erowid experience reports

    Positive Effects 8

    Euphoria 62.5% 70%
    Stimulation 62.5% 70%
    Empathy 50.0% 70%
    Color Enhancement 37.5% 70%
    Introspection 31.2% 70%
    Focus Enhancement 31.2% 70%
    Body High 31.2% 70%
    Music Enhancement 25.0% 70%

    Adverse Effects 6

    Confusion 37.5% 70%
    Anxiety 31.2% 70%
    Headache 25.0% 70%
    Pupil Dilation 25.0% 70%
    Nausea 25.0% 70%
    Jaw Clenching 18.8% 70%

    Combinations TripSit

    5-APDI's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki