5-APDI - Substance Search

Summary TheDrug.Wiki Erowid TripSit

5-APDI (IAP) is a potent but weakly selective serotonin-releasing agent with IC50 values of 82 nM for serotonin, 1,848 nM for dopamine, and 849 nM for norepinephrine. Users report empathogenic warmth, mental stimulation, and occasionally mild visuals, but also pronounced body-load including hyperthermia, profuse sweating, bowel urgency, bruxism, and insomnia. Onset is slow; premature redosing has produced serotonin syndrome-like reactions.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	15-25mg	25-50mg	50-75mg	75mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Peak	Offset	After Effects
Oral	30-90 min	2-5 hrs	3-6 hrs	1-6 hrs
Insufflated	5-15 min	2-4 hrs	2-4 hrs	1-6 hrs
Intravenous	1-5 min	2-4 hrs	2-4 hrs	1-6 hrs

Effect Profile

16 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 2.5

Light 2/10

Mild auditory effects with low visuals and body load

Visual Intensity ×3

3

tracers visual enhancement

Headspace Depth ×3

0

Auditory Effects ×1

4

music enhancement

⚠ Body Load / Somatic Effects ×1

3

teeth grinding sweating

Empathogen 5.1

Moderate+ 5/10

Moderate stimulation with mild empathy, euphoria, and sensory enhancement

Empathy / Social Openness ×3

5

empathy enhancement increased sociability

Euphoria / Mood Elevation ×2

5

euphoria mood lift

Stimulation ×1

6

stimulation wakefulness teeth grinding

Sensory Enhancement ×1

5

music enhancement visual enhancement

Stimulant 3.5

Moderate 4/10

Moderate anxiety/jitters with mild stimulation and euphoria

Stimulation / Energy ×3

5

stimulation wakefulness

Euphoria / Mood Lift ×2

5

euphoria mood lift

Focus / Productivity ×2

0

⚠ Anxiety / Jitters ×1

7

anxiety teeth grinding sweating

Based on reports from:

Erowid Experience Reports PsychonautWiki 5-APDI

Tolerance

Build-up develops over days to weeks of regular use

Reset 3–7 days for acute; 1–3 weeks for full reset

Tolerance Decay

Full tolerance 1d Half tolerance 7d Baseline ~21d

Rapid acute tolerance is frequently reported with SRAs; spacing of several weeks is prudent by analogy to MDMA. Estimates are heuristic and based on anecdotal patterns rather than formal PK/PD studies.

Cross-Tolerances

MDMA

60%

MDA

60%

Other serotonergic empathogens

50%

Effects Erowid

Aggregated from 16 Erowid experience reports

Positive Effects 8

Euphoria 62.5% 70%

Stimulation 62.5% 70%

Empathy 50.0% 70%

Color Enhancement 37.5% 70%

Introspection 31.2% 70%

Focus Enhancement 31.2% 70%

Body High 31.2% 70%

Music Enhancement 25.0% 70%

Adverse Effects 6

Confusion 37.5% 70%

Anxiety 31.2% 70%

Headache 25.0% 70%

Pupil Dilation 25.0% 70%

Nausea 25.0% 70%

Jaw Clenching 18.8% 70%

Combinations TripSit

Cross-Check 5-APDI with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

Erowid 8 reports 7 neutral 1 cautionary visit

Reading & TV Watching Become More Engrossing neutral exp #28260

I had recently acquired 100mg of IAP. One day while home alone, having nothing to do, I decided to try it out. I attempted to weigh out the material using the liquid measurement technique (which I had previously used with great success on 2C-I).

Almost Like I'm Just Starting to Roll neutral exp #34342

After reading several reports about IAP I decided to give the substance a try. The reports I read varied, describing it from totally a waste of time and money to slightly resembling MDMA in some aspects, but in a very mellow and minor sort of way.

Agreeable, Not Worth Repeating neutral exp #29239

Setting: Home, with girlfriend. Southern California, December 2003. 2:20 pm 40 mg IAP ingested, dissolved in vodka. After drinking our shot & a half of vodka, my partner & I sat down to smoke a couple of bowls of good cannabis.

IAP Runup Summary neutral exp #27688

- IAP (Indanylamphetamine) runup summary - I recently had the opportunity to sample this novel morsel and put it to the road test with some friends. I had read the initial glowing reports and praises, so had hopes but kinda figured the first reports would be highly subjective and somewhat inaccurate.

Not Quite MDMA, But Interesting neutral exp #26714

I've tried this substance a few times now... started at 20 mg, went to ~30, then 35-40mg. I plan to continue to go upwards a bit on the dosage, but I'm doubting any new revelations are to be had. I'm not going to give an in-depth trip report, just my thoughts on it so far.

Tri-linear Shifts neutral exp #27585

9:05pm- Diluted the white powder in soda and drank it down. Unusual taste that lingered for about 10 minutes. 9:15pm- Onset, light to deeper tingling sensation in the rear-middle of my brain. Get a glass of water and settle in for the ride.

Mr. Nice Guy neutral exp #24668

I have, for a while, been scouring the internet for different contacts in my endless search for knowledge and experience with research chemicals. As it stands, my drug experiences are not spectacular. I don't really do drugs that often, I just happen to find the subject incredibly interesting.

Super Anti-Depressant cautionary exp #32814

So this saturday night I was particularly depressed that my social anxiety denied me yet another possible social outing, which left me with a desire to get happy through chemicals. I was contemplating what to do when I remembered that lil baggie of IAP I had acquired some time ago but chickened out on doing.

Bluelight 5 threads 4 neutral 1 cautionary visit

Iap First Time Psychonauts Skip This One neutral

<-v IAP v-> buddy of mine ordered sum 2C-I from a reputable source we've used before.. they threw in a free sample of IAP .. .we had never heard of this before... interesting he he. after finding few research materials, mainly erowid, we decided 50mg would be about right.

Iap 2nd Time Kinda Cool neutral

Today I bit the bullet and took 115mg of IAP, my second time with this material. (See this thread for the history). 3:00pm - dose 4:15pm - my notes: -watery/blurry vision -twitching limbs -prickly heat in chest and head and behind eyes -mental processes ...

Iap 50mg 2nd Time Delightfull neutral

This being my second time with IAP left me puzzled, It was bit different from the first time (from the same batch). I dosed round 3:00 or so, and buy 3:30 I was starting to feel "off" not in a good way, uncomfortable and a bit nauseas. This continued as I watched T.v. for about another 45 minutes.

Iap Insufflated First Time Tony Montana Style neutral

IAP...Tony Montana Style 185 lb. Male Around 50mg IAP Insufflated A little over a week ago I snorted 50mg of IAP. There is not very much known about this drug. A few people I know have eaten about 50mg of IAP and didnt experience too much. So I decided to snort it after experiencing rollin for the first time.

Iap First Time Super Anti Depressent cautionary

So this saturday night I was particularly depressed that my Social anxiety denied me yet another possible social outing, which left me with a desire to get happy through chemicals. I was contemplating what to do when I remembered that lil baggie of IAP I had acquired some time ago but chickened out on doing.

5-APDI's nerd page Pharmacology, chemical data, effect profiles, and more

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5-APDI Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 4 corroborating sources 1 ROA with full dose ladder duration data present 20 combo interactions documented classified Tentative classified Research-chemical