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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    5-MAPB

    Aliases: 5mapb

    Psychedelic Stimulant Empathogen Research-chemical

    Summary TheDrug.Wiki TripSit PsychonautWiki

    5-MAPB is a potent non-selective monoamine releaser with approximately 3-5 times the potency of MDMA at serotonin and norepinephrine transporters. It functions as a full 5-HT2B receptor agonist, which suggests potential cardiac valve toxicity with repeated use; spacing sessions at least 4-6 weeks apart is strongly advised. Significant batch-to-batch variability in potency has been documented; always use reagent testing and start with a low dose.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 40-60mg 60-80mg 80-100mg 100mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-60 min 45-90 min 2-4 hrs 1.5-3 hrs 6-48 hrs 5-8 hrs
    Insufflated 4-19 min 19-40 min 2-4 hrs 1.5-3 hrs 6-48 hrs 5-8 hrs
    Rectal 15-40 min 30-60 min 2-4 hrs 1.5-3 hrs 6-48 hrs 5-8 hrs
    Intramuscular 10-30 min 19-40 min 2-4 hrs 1.5-3 hrs 6-48 hrs 5-8 hrs

    Effect Profile

    36 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 21 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.0
    Moderate+ 5/10

    Strong auditory effects, body load, and visuals with low headspace

    Visual Intensity ×3
    8
    colour enhancement visual acuity enhancement
    Headspace Depth ×3
    2
    time distortion
    Auditory Effects ×1
    10
    music enhancement
    ⚠ Body Load / Somatic Effects ×1
    10
    vasoconstriction nausea teeth grinding increased heart rate sweating
    Empathogen 10.0
    Extreme 10/10

    Strong empathy, euphoria, stimulation, and sensory enhancement

    Empathy / Social Openness ×3
    10
    empathy enhancement empathy, affection and sociability enhancement increased sociability
    Euphoria / Mood Elevation ×2
    10
    cognitive euphoria euphoria mood lift
    Stimulation ×1
    10
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    10
    tactile enhancement music enhancement colour enhancement visual acuity enhancement
    Stimulant 8.8
    Intense+ 9/10

    Strong stimulation, euphoria, focus, and anxiety/jitters

    Stimulation / Energy ×3
    10
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    10
    cognitive euphoria euphoria mood lift motivation enhancement
    Focus / Productivity ×2
    10
    analysis enhancement memory enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate vasoconstriction sweating
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 5-MAPB
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~28d

    Empathogen tolerance builds quickly and decays over weeks; spacing sessions by ≥4–6 weeks is prudent (anecdotal/user‑consensus; limited formal data).

    Cross-Tolerances

    MDMA
    60%
    5‑APB
    50%
    6‑APB
    50%
    Other serotonin releasers
    40%

    Effects Erowid Bluelight

    Aggregated from 21 Erowid and 15 Bluelight experience reports

    Positive Effects 36

    Euphoria 75.0% 94%
    Empathy 72.2% 88%
    Stimulation 66.7% 86%
    Music Enhancement 58.3% 85%
    Focus Enhancement 42.9% 70%
    Sociability Enhancement 40.0% 90%
    Visual Distortions 38.9% 70%
    Tactile Enhancement 33.4% 92%
    Lightness 33.3% 84%
    Contentment 33.3% 84%
    Color Enhancement 33.3% 80%
    Body High 27.8% 85%
    Tingling 26.7% 84%
    Motor Enhancement 20.0% 87%
    Introspection 14.3% 70%
    Group Bonding 13.3% 82%
    Mood Increase 6.7% 85%
    Genital Sensitivity Change 6.7% 75%
    Insight 6.7% 70%
    Love 6.7% 85%

    Adverse Effects 15

    Anxiety 57.1% 70%
    Jaw Clenching 44.5% 85%
    Insomnia 40.0% 79%
    Body Temperature Change 26.7% 79%
    Nausea 22.2% 76%
    Muscle Tension 19.0% 70%
    Increased Heart Rate 14.3% 70%
    Sweating 13.9% 88%
    Chills 6.7% 80%
    Ataxia 6.7% 75%
    Communication Suppression 6.7% 80%
    Dry Mouth 6.7% 80%
    Distractibility 6.7% 75%
    Diarrhea 6.7% 80%
    Emotional Blunting 6.7% 75%

    Combinations TripSit

    5-MAPB's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 Bluelight 📖 PsychonautWiki