5-APB
Aliases: Nrg-3, 6-apb, Benzofury, Head candy, 5apb, 6apb
Categories
Summary
6-APB acts as a potent serotonin-norepinephrine-dopamine releasing agent and is a high-efficacy full agonist at the 5-HT2B receptor (Ki = 3.7 nM), making chronic or frequent use a theoretical driver of drug-induced valvular heart disease. Users who dose more than once monthly should consider periodic cardiac monitoring. Multiple salt forms exist with significantly different potencies: freebase is approximately 20% stronger than HCl and 65% stronger than succinate. Oral onset can exceed one hour; premature redosing is the leading cause of overdose. Strong doses produce MDA-like closed-eye visuals, pronounced vasoconstriction, bruxism, mydriasis, and hyperthermia.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-60mg | 60-80mg | 80-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 19-60 min | 45-90 min | 2.0-4.0 hrs | 1.5-3.0 hrs | 6.0-48.0 hrs | 7.0-8.0 hrs |
| Insufflated | 4-15 min | 19-40 min | 2.0-4.0 hrs | 1.5-3.0 hrs | 4.0-24.0 hrs | 7.0-8.0 hrs |
| Rectal | 10-30 min | 45-90 min | 2.5-4.0 hrs | 2.0-3.0 hrs | 6.0-24.0 hrs | 7.0-8.0 hrs |
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Cross-tolerance
Effects
Positive
- Stimulation
- Physical euphoria
- Creativity enhancement
Negative
- Increased heart rate
- Increased perspiration
- Teeth grinding
- Jaw clenching
- Nausea
- Temperature regulation suppression
- Temporary erectile dysfunction
- Pupil dilation
- Increased blood pressure
- Nystagmus
- Vasoconstriction
- Sweating
- Insomnia
- Abnormal heartbeat
- Seizure
- Dry mouth
- Difficulty urinating
- Muscle contractions
- Stimulation and sedation
- Increased bodily temperature
- Sedative
- Sometimes stimulating effects
- Spontaneous bodily sensations
- Excessive yawning
- Sedation
- Stamina intensification
Positive
- Euphoria
- Empathy enhancement
- Sociability enhancement
- Cognitive euphoria
- Anxiety suppression
- Affection enhancement
- Emotion enhancement
- Increased sense of humor
- Motivation enhancement
- Novelty enhancement
- Personal meaning enhancement
- Focus enhancement
- Increased sociability
- Empathy
- Feelings of empathy
- Empathy, affection and sociability enhancement
- Memory enhancement
- Analysis enhancement
- Wakefulness
- Dream potentiation
- Mindfulness
- Unity and interconnectedness
- Laughter fits
- Immersion intensification
Negative
- Memory suppression
- Anxiety
- Paranoia
- Thought deceleration
- Depression
- Irritability
- Compulsive redosing
- Cognitive fatigue
- Motivation depression
- Delusion
- Thought disorganization
- Brain zaps
- Derealization
- Suicidal ideation
- Time distortion
- Thought acceleration
- Focus intensification
- Peripheral information misinterpretation
- Existential self-realization
- Emotion intensification
- Personal meaning intensification
Positive
- Increased music appreciation
- Mild visual enhancement
- Tactile enhancement
- Increased libido
- Music appreciation
- Color enhancement
- Pattern recognition enhancement
- Tracers
- Visual geometry
- Bodily control enhancement
- Auditory acuity enhancement
Negative
- Disinhibition
- Appetite suppression
- Dehydration
- Spontaneous physical sensations
- Symmetrical texture repetition
- Auditory hallucination
- Auditory distortion
- Vibrating vision
- External hallucination
- Internal hallucination
- Autonomous entity
- Perspective hallucination
- Tactile intensification