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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    5-MeO-AMT Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 5 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 17 combo interactions documented
    • classified Research-chemical

    Aliases: Alpha, Alpha-o, Ξ‘,o-dms, Ξ‘,o-dimethylserotonin, 5meoamt, 5-MeO-Ξ±MT

    Psychedelic Stimulant Empathogen Research-chemical

    Summary TheDrug.Wiki Erowid TripSit

    One of the most potent psychedelic tryptamines known, requiring extreme caution with dosing. Highly dose-sensitive with medical emergencies reported at doses as low as 8 mg oral. Has been misrepresented as LSD on blotter and gelatin tabs, leading to multiple hospitalizations and deaths.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 1-2mg 2-4mg 4-6mg 6mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 0.5-2 hrs 1-2 hrs 3-8 hrs 3-6 hrs 4-24 hrs
    Insufflated 4-19 min 19-40 min 3-8 hrs 3-6 hrs 4-24 hrs
    Rectal 4-19 min 30-60 min 3-8 hrs 3-6 hrs 4-24 hrs

    Effect Profile

    144 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 136 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.5
    Strong 6/10

    Strong visuals, auditory effects, and body load with mild headspace

    Visual Intensity ×3
    10
    color enhancement pattern recognition enhancement brightened colour
    Headspace Depth ×3
    4
    confusion
    Auditory Effects ×1
    10
    auditory enhancement
    ⚠ Body Load / Somatic Effects ×1
    10
    temperature regulation suppression nausea muscle tension jaw clenching
    Empathogen 9.4
    Intense+ 9/10

    Strong empathy, stimulation, sensory enhancement, and euphoria

    Empathy / Social Openness ×3
    10
    empathy enhancement empathy sociability enhancement
    Euphoria / Mood Elevation ×2
    8
    euphoria mood elevation
    Stimulation ×1
    10
    physical stimulation mental stimulation restlessness
    Sensory Enhancement ×1
    10
    tactile enhancement enhanced tactile sensation color enhancement
    Stimulant 5.8
    Strong 6/10

    Strong anxiety/jitters, stimulation, and euphoria with low focus

    Stimulation / Energy ×3
    8
    physical stimulation mental stimulation
    Euphoria / Mood Lift ×2
    8
    euphoria mood elevation
    Focus / Productivity ×2
    3
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness jaw clenching muscle tension
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 5-MeO-AMT
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~10d

    Animal data show rapid tolerance to head-twitch with repeated dosing; users commonly report diminished effects for several days after use with partial recovery by ~3 days and near-baseline after ~10–14 days. Cross-tolerance with classic psychedelics is expected given shared 5‑HT2A agonism, but human quantification is lacking.

    Cross-Tolerances

    LSD
    50%
    Psilocybin
    50%
    DMT
    40%

    Effects Erowid Bluelight

    Aggregated from 136 Erowid and 8 Bluelight experience reports

    Positive Effects 32

    Visual Distortions 74.3% 80%
    Brightness Enhancement 37.5% 87%
    Melting/flowing 37.5% 83%
    Thought Acceleration 37.5% 80%
    Surface Breathing 37.5% 85%
    Patterning 37.5% 83%
    Stimulation 35.4% 81%
    Euphoria 32.6% 86%
    Music Enhancement 31.2% 90%
    Color Enhancement 30.5% 84%
    Tactile Enhancement 27.1% 80%
    Visual Trails 25.0% 88%
    Joy 25.0% 80%
    Geometric Imagery 25.0% 82%
    Awe 25.0% 78%
    Auditory-Visual Synesthesia 25.0% 82%
    Focus Enhancement 18.7% 75%
    Empathy 18.7% 80%
    Body High 15.3% 85%
    Tessellation 12.5% 80%

    Adverse Effects 45

    Body Load 62.5% 81%
    Nausea 57.0% 87%
    Anxiety 41.6% 78%
    Vomiting 37.5% 92%
    Diarrhea 37.5% 82%
    Insomnia 37.5% 88%
    Dizziness 25.0% 90%
    Depersonalization 25.0% 82%
    Confusion 21.3% 70%
    Headache 20.2% 75%
    Auditory Effects 18.7% 90%
    Open-Eye Visuals 13.2% 75%
    Muscle Tension 13.2% 70%
    Dry Mouth 12.5% 75%
    Stomach Cramps 12.5% 75%
    Thought Disorganization 12.5% 75%
    Body Temperature Change 12.5% 70%
    Chills 12.5% 80%
    Focus Suppression 12.5% 80%
    Sociability Suppression 12.5% 75%

    Combinations TripSit

    Cross-Check 5-MeO-AMT with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Bluelight 1 thread 1 neutral visit
    Alpha Bromalose An Undiscovered Beauty neutral

    After synthesizing a sample of (5ΞΎ)-1,2-O-[2,2,2-Tribromoethylidene]- Ξ± -xylo-hexofuranose (Otherwise called 'bromalose', a brominated acetal derivative of glucose, I set about testing this molecule on myself.

    scraped 2026-03-14

    Bluelight Reference Guide Bluelight

    The Big & Dandy 5-MeO-AMT Thread

    Anyone got any tips on how to prevent diarrhea/intestinal problems with 5-MeO-AMT?

    Read full thread on Bluelight β†’
    5-MeO-AMT's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    πŸ“˜ Experience Reports πŸ“– TheDrug.Wiki πŸ“– Bluelight πŸ“– PsychonautWiki