I'm pretty opiate naive and have only done hydrocodone (10-20mg) and oxycodone (usually just 10mg, a couple times 15mg) a handful of times. I got my hands on some DHC recently, both in the IR and ER forms and I wanted to give them a try.
Acetyldihydrocodeine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- partial dose data
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- partial dose data
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Dhc, Df-118, Drocode, Parzone, Paramol
Summary
Acetyldihydrocodeine is a 6-acetyl ester prodrug of dihydrocodeine discovered in Germany in 1914. It is rapidly deacetylated to dihydrocodeine and subsequently O-demethylated via CYP2D6 to the more potent active metabolite dihydromorphine. Potency is approximately 1.2-1.5 times that of dihydrocodeine by weight.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-100mg | 100-150mg | - | 150-200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-2 hrs | 2-3 hrs | 3-4 hrs |
| Rectal | 15-45 min | 30-60 min | 1-2 hrs | 2-3 hrs | 3-4 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 2-3 hrs | 3-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
7.9
Intense
8/10
Strong euphoria and pain relief with moderate itching/nausea and sedation
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
mood lift
Analgesia
×2
8
pain relief
analgesia
Sedation / Relaxation
×1
6
sedation
muscle relaxation
dream potentiation
Itching / Nausea
×1
7
nausea
constipation
dry mouth
Add to PsychonautWiki Journal
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Name
Acetyldihydrocodeine
Unit
mg
Description
Acetyldihydrocodeine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 50-100 · common 100-150 · heavy 150-200+ Rectal dose (mg): threshold 5 Insufflated dose (mg): threshold 5 Oral duration: onset 0.33-1h · come-up 0.5-1h · peak 1-2h · offset 2-3h · total 3-4h · after-effects 1-3h Rectal duration: onset 15-45m · come-up 0.5-1h · peak 1-2h · offset 2-3h · total 3-4h · after-effects 1-3h Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-2h · offset 2-3h · total 3-4h · after-effects 1-3h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 125 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
5d
Half tolerance
10d
Baseline
~30d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Opioid tolerance builds rapidly with consecutive daily use; partial tolerance can develop within several days and may take weeks to substantially decay. Cross-tolerance is broad across µ-opioid agonists. Ceiling effects may occur due to CYP2D6 saturation, leading to diminishing analgesic returns but increased side-effect burden at higher doses.
Cross-Tolerances
Effects
Positive
- Physical euphoria
- Pain relief
- Cough suppression
- Muscle relaxation
- Analgesia
Negative
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Pupil constriction
- Difficulty urinating
- Relaxant
Positive
- Cognitive euphoria
- Anxiety suppression
- Dream potentiation
- Euphoria
- Mood lift
Negative
- Constipation
- Thought deceleration
- Compulsive redosing
- Dizziness
Negative
- Appetite suppression
- Decreased libido
- Orgasm suppression
- Double vision
- Cognitive dysphoria
- Dulled perception
- Internal hallucination
- Internal hallucinations
Combinations
Cross-Check Acetyldihydrocodeine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
Acetyldihydrocodeine's nerd page
Pharmacology, chemical data, effect profiles, and more
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