Acetyldihydrocodeine
Aliases: Dhc, Df-118, Drocode, Parzone, Paramol
Categories
Summary
Acetyldihydrocodeine is a 6-acetyl ester prodrug of dihydrocodeine discovered in Germany in 1914. It is rapidly deacetylated to dihydrocodeine and subsequently O-demethylated via CYP2D6 to the more potent active metabolite dihydromorphine. Potency is approximately 1.2-1.5 times that of dihydrocodeine by weight. CYP2D6 poor metabolizers may experience reduced effects, while ultrarapid metabolizers face greater overdose risk. Start with lower doses if opioid-naive.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-100mg | 100-150mg | - | 150-200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-2 hrs | 2-3 hrs | 1-3 hrs | 180-0 min |
| Rectal | 15-45 min | 30-60 min | 1-2 hrs | 2-3 hrs | 1-3 hrs | 180-0 min |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 2-3 hrs | 1-3 hrs | 180-0 min |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Physical euphoria
- Pain relief
- Cough suppression
- Muscle relaxation
- Analgesia
Negative
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Pupil constriction
- Difficulty urinating
- Relaxant
Positive
- Cognitive euphoria
- Anxiety suppression
- Dream potentiation
- Euphoria
- Mood lift
- Cognitive Euphoria
Negative
- Constipation
- Thought deceleration
- Compulsive redosing
- Dizziness
Positive
Negative
- Appetite suppression
- Decreased libido
- Orgasm suppression
- Double vision
- Decreased Libido
- Appetite Suppression
- Cognitive dysphoria
- Dulled perception
- Internal hallucination
- Internal hallucinations