Acetyldihydrocodeine Encyclopedic

Encyclopedic

Typical encyclopedia coverage. Cross-reference for important decisions.

3 corroborating sources

partial dose data

duration data present

29 combo interactions documented

classified Research-chemical

dose data not in PW/TripSit (unverifiable)

Aliases: Dhc, Df-118, Drocode, Parzone, Paramol

Summary dose.wiki TripSit

Acetyldihydrocodeine is a 6-acetyl ester prodrug of dihydrocodeine discovered in Germany in 1914. It is rapidly deacetylated to dihydrocodeine and subsequently O-demethylated via CYP2D6 to the more potent active metabolite dihydromorphine. Potency is approximately 1.2-1.5 times that of dihydrocodeine by weight.

Dose Information source not identified

Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.

ROA	Light	Common	Heavy
Oral	50-100mg	100-150mg	150-200mg+

Light Common Heavy

Sources· no ladder identified

Oral

Dose ladder — source not identified

Onset, Duration & After-effects dose.wiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	20-60 min	30-60 min	1-2 hrs	2-3 hrs	1-3 hrs	3-4 hrs
Rectal	15-45 min	30-60 min	1-2 hrs	2-3 hrs	1-3 hrs	3-4 hrs
Insufflated	5-15 min	15-30 min	1-2 hrs	2-3 hrs	1-3 hrs	3-4 hrs

Effect Profile

Scores (0–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 7.9

Intense 8/10

Strong euphoria and pain relief with moderate itching/nausea and sedation

Euphoria / Warmth ×3

physical euphoria cognitive euphoria euphoria mood lift

Analgesia ×2

pain relief analgesia

Sedation / Relaxation ×1

sedation muscle relaxation dream potentiation

⚠ Itching / Nausea ×1

nausea constipation dry mouth

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.

No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

Cross-Tolerances

morphine

oxycodone

heroin/diacetylmorphine

hydromorphone

Effects dose.wiki TripSit

Positive

Negative

Neutral

Positive

Negative

Neutral

Combinations TripSit

Cross-Check Acetyldihydrocodeine with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Bluelight 1 thread 1 cautionary visit

Dhc 100mg First Time Stimulating Sedation W Hangover cautionary

I'm pretty opiate naive and have only done hydrocodone (10-20mg) and oxycodone (usually just 10mg, a couple times 15mg) a handful of times. I got my hands on some DHC recently, both in the IR and ER forms and I wanted to give them a try.

Acetyldihydrocodeine's nerd page Pharmacology, chemical data, effect profiles, and more

→

Helpful Links

📖 dose.wiki 📖 TripSit

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track Acetyldihydrocodeine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

Name

Acetyldihydrocodeine

Unit

Description

Acetyldihydrocodeine
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 50-100 · common 100-150 · heavy 150-200+

Oral duration: onset 0.33-1h · come-up 0.5-1h · peak 1-2h · offset 2-3h · total 3-4h · after-effects 1-3h
Rectal duration: onset 15-45m · come-up 0.5-1h · peak 1-2h · offset 2-3h · total 3-4h · after-effects 1-3h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-2h · offset 2-3h · total 3-4h · after-effects 1-3h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 125 mg (Oral).

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Acetyldihydrocodeine? Let us know. Reports are reviewed by moderators — this is not posted publicly.

Acetyldihydrocodeine Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 3 corroborating sources partial dose data duration data present 29 combo interactions documented classified Research-chemical dose data not in PW/TripSit (unverifiable)