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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Acetyldihydrocodeine

    Aliases: Dhc, Df-118, Drocode, Parzone, Paramol

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki TripSit

    Acetyldihydrocodeine is a 6-acetyl ester prodrug of dihydrocodeine discovered in Germany in 1914. It is rapidly deacetylated to dihydrocodeine and subsequently O-demethylated via CYP2D6 to the more potent active metabolite dihydromorphine. Potency is approximately 1.2-1.5 times that of dihydrocodeine by weight.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-150mg - 150-200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-60 min 30-60 min 1-2 hrs 2-3 hrs 1-3 hrs 3.8-7 hrs
    Rectal 15-45 min 30-60 min 1-2 hrs 2-3 hrs 1-3 hrs 3.8-6.8 hrs
    Insufflated 5-15 min 15-30 min 1-2 hrs 2-3 hrs 1-3 hrs 3.3-5.8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.9
    Intense 8/10

    Strong euphoria and pain relief with moderate itching/nausea and sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria mood lift
    Analgesia ×2
    8
    pain relief analgesia
    Sedation / Relaxation ×1
    6
    sedation muscle relaxation dream potentiation
    ⚠ Itching / Nausea ×1
    7
    nausea constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Acetyldihydrocodeine
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Cross-Tolerances

    morphine
    90%
    oxycodone
    90%
    heroin/diacetylmorphine
    90%
    hydromorphone
    90%

    Effects TheDrug.Wiki TripSit

    Positive
    • Physical euphoria
    • Pain relief
    • Cough suppression
    • Muscle relaxation
    • Analgesia
    Negative
    • Respiratory depression
    • Nausea
    • Dry Mouth
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    • Difficulty urinating
    • Relaxant
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Dream potentiation
    • Euphoria
    • Mood lift
    • Cognitive Euphoria
    Negative
    • Constipation
    • Thought deceleration
    • Compulsive redosing
    • Dizziness
    Negative
    • Appetite suppression
    • Decreased libido
    • Orgasm suppression
    • Double vision
    • Decreased Libido
    • Appetite Suppression
    • Cognitive dysphoria
    Neutral
    • Dulled perception
    • Internal hallucination
    • Internal hallucinations

    Combinations TripSit

    Acetyldihydrocodeine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki