I'm pretty opiate naive and have only done hydrocodone (10-20mg) and oxycodone (usually just 10mg, a couple times 15mg) a handful of times. I got my hands on some DHC recently, both in the IR and ER forms and I wanted to give them a try.
Acetyldihydrocodeine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- partial dose data
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- partial dose data
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Dhc, Df-118, Drocode, Parzone, Paramol
Summary
Acetyldihydrocodeine is a 6-acetyl ester prodrug of dihydrocodeine discovered in Germany in 1914. It is rapidly deacetylated to dihydrocodeine and subsequently O-demethylated via CYP2D6 to the more potent active metabolite dihydromorphine. Potency is approximately 1.2-1.5 times that of dihydrocodeine by weight.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-100mg | 100-150mg | - | 150-200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-2 hrs | 2-3 hrs | 3-4 hrs |
| Rectal | 15-45 min | 30-60 min | 1-2 hrs | 2-3 hrs | 3-4 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 2-3 hrs | 3-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
7.9
Intense
8/10
Strong euphoria and pain relief with moderate itching/nausea and sedation
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
mood lift
Analgesia
×2
8
pain relief
analgesia
Sedation / Relaxation
×1
6
sedation
muscle relaxation
dream potentiation
Itching / Nausea
×1
7
nausea
constipation
dry mouth
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
5d
Half tolerance
10d
Baseline
~30d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Opioid tolerance builds rapidly with consecutive daily use; partial tolerance can develop within several days and may take weeks to substantially decay. Cross-tolerance is broad across µ-opioid agonists. Ceiling effects may occur due to CYP2D6 saturation, leading to diminishing analgesic returns but increased side-effect burden at higher doses.
Cross-Tolerances
Effects
Positive
- Physical euphoria
- Pain relief
- Cough suppression
- Muscle relaxation
- Analgesia
Negative
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Pupil constriction
- Difficulty urinating
- Relaxant
Positive
- Cognitive euphoria
- Anxiety suppression
- Dream potentiation
- Euphoria
- Mood lift
- Cognitive Euphoria
Negative
- Constipation
- Thought deceleration
- Compulsive redosing
- Dizziness
Negative
- Appetite suppression
- Decreased libido
- Orgasm suppression
- Double vision
- Decreased Libido
- Appetite Suppression
- Cognitive dysphoria
- Dulled perception
- Internal hallucination
- Internal hallucinations
Combinations
Cross-Check Acetyldihydrocodeine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
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