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    Disclaimer
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Hydromorphone

    Aliases: Exalgo, Dilaudid, Jurnista, Diluadid, Palladone

    Depressant Opioid

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Hydromorphone is approximately 5-8 times more potent than morphine. It has low oral bioavailability and is most commonly administered intravenously in medical settings. Intranasal bioavailability is approximately 52-58%, while rectal bioavailability is lower at around 36% with high variability.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral BA ~24% 1-2mg 2-4mg 4-8mg 8mg+
    Intravenous 1-2mg 2-4mg 4-6mg 6mg+
    Insufflated BA 52-58% 1-2mg 2-4mg 4-8mg 8mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-30 min 1-2 hrs 2-4 hrs 30-60 min 1-12 hrs
    Intravenous 1-5 min 5-10 min 30-60 min 2-4 hrs 1-12 hrs
    Insufflated 4-5 min 10-20 min 30-90 min 1-2 hrs 1-2 hrs
    Rectal 15-30 min - 1-2 hrs 2-3 hrs 12-12 hrs

    Opioid MME Calculator

    ⚠ Citation & Disclaimer: Conversion factors sourced from the NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025), the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain, and the MDCalc MME Calculator. These are approximate equianalgesic ratios for educational reference only. Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration. This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.
    mg
    2 mg Hydromorphone
    ≈
    — mg Morphine

    ⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.

    Effect Profile

    91 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 70 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 8.3
    Intense 8/10

    Strong euphoria, pain relief, itching/nausea, and sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria mood lift
    Analgesia ×2
    10
    pain relief analgesia
    Sedation / Relaxation ×1
    8
    sedation dream potentiation
    ⚠ Itching / Nausea ×1
    10
    nausea constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Hydromorphone
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 7d Half tolerance 3d Baseline ~14d

    Tolerance builds rapidly with daily use and decays over days to weeks; incomplete cross‑tolerance is typical when switching opioids or routes. Values above are indicative, synthesized from clinical practice norms and user reports rather than controlled PK/PD studies.

    Cross-Tolerances

    Morphine
    80%
    Oxycodone
    70%
    Heroin (diacetylmorphine)
    80%

    Effects Erowid Bluelight

    Aggregated from 70 Erowid and 21 Bluelight experience reports

    Positive Effects 29

    Euphoria 56.1% 90%
    Contentment 42.9% 84%
    Sedation 37.3% 89%
    Empathy 25.7% 70%
    Anxiety Suppression 24.2% 80%
    Body High 20.9% 89%
    Tactile Enhancement 20.0% 70%
    Pain Relief 19.8% 89%
    Stimulation 19.8% 78%
    Thought Suppression 19.0% 76%
    Focus Enhancement 15.4% 85%
    Muscle Relaxation 14.3% 88%
    Heaviness 14.3% 83%
    Sociability Enhancement 14.3% 80%
    Tingling 14.3% 83%
    Music Enhancement 14.3% 75%
    Color Enhancement 9.9% 75%
    Peace 9.5% 85%
    Vivid Dreams 9.5% 85%
    Joy 9.5% 85%

    Adverse Effects 24

    Nausea 28.5% 78%
    Dizziness 14.3% 75%
    Flushing 14.3% 82%
    Pupil Dilation 10.0% 70%
    Confusion 10.0% 70%
    Emotional Blunting 9.5% 80%
    Dry Mouth 9.5% 82%
    Thought Disorganization 9.5% 70%
    Muscle Tension 7.1% 70%
    Sweating 6.6% 85%
    Increased Heart Rate 5.7% 70%
    Jaw Clenching 5.7% 70%
    Restlessness 4.8% 85%
    Dysphoria 4.8% 70%
    Clammy Skin 4.8% 70%
    Paranoia 4.8% 70%
    Urinary Retention 4.8% 85%
    Headache 4.8% 75%
    Constipation 4.8% 85%
    Irritability 4.8% 90%

    Combinations TripSit

    Pill Identifiers

    11 known pill identifiers on record — view imprints, colors, shapes, and images
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    Hydromorphone's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki