I use to live a life to die for, everything a normal seventeen year old could ask for I had... Beautiful girlfriend, loving parents and siblings, money, and an enjoyable life. This all changed on my seventeenth birthday when I first injected Dilaudid.
Hydromorphone
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Aliases: Exalgo, Dilaudid, Jurnista, Diluadid, Palladone
Summary
Hydromorphone (Dilaudid) is an opioid. It acts as an opioid agonist that binds to different types of opioid receptors, with its analgesic effect attributed mainly to the mu-opioid receptors and minor affinity for the delta and kappa receptors. It is approximately 5-8 times more potent than morphine. It has low oral bioavailability and is most commonly administered intravenously in medical settings; intranasal bioavailability is approximately 52-58%, while rectal bioavailability is lower at around 36% with high variability.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~24% | 1-2mg | 2-4mg | 4-8mg | 8mg+ |
| Intravenous | 1-2mg | 2-4mg | 4-6mg | 6mg+ |
| Insufflated BA 52-58% | 1-2mg | 2-4mg | 4-8mg | 8mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 15-30 min | 1-2 hrs | 2-4 hrs | 30-60 min |
| Intravenous | 1-5 min | 5-10 min | 30-60 min | 2-4 hrs |
| Insufflated | 4-5 min | 10-20 min | 30-90 min | 1-2 hrs |
| Rectal | 15-30 min | - | 1-2 hrs | 2-3 hrs |
Opioid MME Calculator
⚠ Citation & Disclaimer:
Conversion factors sourced from the
NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025),
the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain,
and the MDCalc MME Calculator.
These are approximate equianalgesic ratios for educational reference only.
Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration.
This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.
mg
2
mg
Hydromorphone
≈
—
mg
Morphine
| Substance | Equivalent Dose | MME Factor |
|---|
⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
91 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 70 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
8.3
Intense
8/10
Strong euphoria, pain relief, itching/nausea, and sedation
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
mood lift
Analgesia
×2
10
pain relief
analgesia
Sedation / Relaxation
×1
8
sedation
dream potentiation
Itching / Nausea
×1
10
nausea
constipation
dry mouth
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
7d
Half tolerance
7d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance builds rapidly with daily use and decays over days to weeks; incomplete cross‑tolerance is typical when switching opioids or routes. Values above are indicative, synthesized from clinical practice norms and user reports rather than controlled PK/PD studies.
Cross-Tolerances
Effects
Aggregated from 70 Erowid and 21 Bluelight experience reports
Positive Effects 29
Euphoria
56.1%
90%
Contentment
42.9%
84%
Sedation
37.3%
89%
Empathy
25.7%
70%
Anxiety Suppression
24.2%
80%
Body High
20.9%
89%
Tactile Enhancement
20.0%
70%
Pain Relief
19.8%
89%
Stimulation
19.8%
78%
Thought Suppression
19.0%
76%
Focus Enhancement
15.4%
85%
Muscle Relaxation
14.3%
88%
Heaviness
14.3%
83%
Sociability Enhancement
14.3%
80%
Tingling
14.3%
83%
Music Enhancement
14.3%
75%
Color Enhancement
9.9%
75%
Peace
9.5%
85%
Vivid Dreams
9.5%
85%
Joy
9.5%
85%
Adverse Effects 24
Nausea
28.5%
78%
Dizziness
14.3%
75%
Flushing
14.3%
82%
Pupil Dilation
10.0%
70%
Confusion
10.0%
70%
Emotional Blunting
9.5%
80%
Dry Mouth
9.5%
82%
Thought Disorganization
9.5%
70%
Muscle Tension
7.1%
70%
Sweating
6.6%
85%
Increased Heart Rate
5.7%
70%
Jaw Clenching
5.7%
70%
Restlessness
4.8%
85%
Dysphoria
4.8%
70%
Clammy Skin
4.8%
70%
Paranoia
4.8%
70%
Urinary Retention
4.8%
85%
Headache
4.8%
75%
Constipation
4.8%
85%
Irritability
4.8%
90%
Combinations
Cross-Check Hydromorphone with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 2 positive 4 neutral 2 cautionary visit
I'm 38. Frequent weed smoker. Have experience with acid when much younger, but have spent most of my 30s dabbling in pharms. Mostly extracting codeine from pain meds. This is my first time experiencing with this particular drug.
I have been toying with idea of trying Intravenous Injection, but I was bit 'anti-needles' and stuff because of that notorious 'needle stimga' if you get my drift. After endless hours of researching dilaudid and dosages, I looked into the negative side of dilaudid's addictive properties.
I had never used needles before. I am an opiate addict, and I would say I have about a tolerance of twice what the normal person would. I have only done dilaudid once, I snorted an 8mg one and it did little to NOTHING, just took my withdrawl symptoms away.
To start off, Id consider myself a rather well seasoned opiate user but have never had a sincere habit or addiction that lasted more than a month or two. I have used orally, intravenously, intramuscularly, subcutaneously and insufflated opiates such as oxycodone, hydrocodone, codeine, dihydrocodeine, morphine, methado...
I have been enjoying a dalliance with Dilaudid for the past 2 years or so. It's a drug with effects quite different than those of other drugs I tried, and one with both significant benefits and drawbacks.
[Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects.
Hey All, I thought I'd sumbit a report on my hydromorphone addiction, because of it's expensive street price people dont really support an addiction of it purely, but when you get perscriptions like I did you can easily become addicted.
Bluelight 8 threads 2 positive 5 neutral 1 cautionary visit
some people have recently called me out as a drug racist! no names, (phrozen)! but even though my birthday is this month I'll do What phrozen wants! this months substance of the month is Hydromorpnone! Its one of my favorite Opioids. And I love opioids. Even though it does not last long, I still love the Euphoria.
6mg Dilaudid (Hydromorphone) IV – Second Attempt – Euphoric Paralysis Okay a little background on the author. I’m a 20 year old make college student living the United States.
8mg Dilaudid - Hydromorphone IV - First Time - Dreamy Bliss of Nothing 8mg Dilaudid - Hydromorphone IV - First Time - Dreamy Bliss of Nothing After endless hours of researching on dilaudid and expereinces and dosages, as I have been toying with idea to try Intravenous Injection method as I have never tired intravenousl...
Okay about a year ago I started snorting Dilaudid off and on. I'm 21 years old, male, 5'8 140. I never really let it get too bad out of hand. I would stop for a month or a few weeks here and here ect. But lets cut to the chase. A couple months ago I went to jail over some bullshit I didnt do. After 46 days I got out.
Substance: IV Hydromorphone, 2mg. Exp: First Time. Height/Weight: 5'11", 120lbs, slim/slender. So I've been trying to get off of hydromorphone, and I tried to avoid IV'ing it, always snorting it. I never really had the chance to IV it anyway, but I ran across a wrapped sterile syringe (trusted source) last night.
ave a had an fucking awesome week lads. On saturday I had my first experience with 2C-I, a 20mg dose which a friend of a friend gave to myself, and the same he gave to my best friend. It is a drug I had wanted to try for years but was lacking connections for.
I tried hydromorphone (diluaudid) recently and thought I would write a somewhat detailed report on it, since it's now my absolute favorite opiate, and I've done a LOT (oxycontin, hydrocodone, oxycodone, codeine, methadone, tramadol, opium). I am a small chick - four foot eleven and 85 pounds.
This is actually a very delayed trip report but I find it interesting and hopefully amusing to anyone who reads it. This is all took place about 3 years ago while at home and while hospitalized with an infection in my spine.
Pill Identifiers
11
known pill identifiers on record — view imprints, colors, shapes, and images
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Helpful Links
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