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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Hydromorphone

    Aliases: Exalgo, Dilaudid, Jurnista, Diluadid, Palladone

    Categories

    Depressant Opioid
    Hydromorphone structure

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Hydromorphone is approximately 5-8 times more potent than morphine. It has low oral bioavailability and is most commonly administered intravenously in medical settings. Intranasal bioavailability is approximately 52-58%, while rectal bioavailability is lower at around 36% with high variability. Fatal overdose risk increases dramatically when combined with other CNS depressants. Unlike many opioids, hydromorphone is primarily metabolized by glucuronidation rather than cytochrome P450 enzymes.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral BA ~24% 1-2mg 2-4mg 4-8mg 8mg+
    Intravenous 1-2mg 2-4mg 4-6mg 6mg+
    Insufflated BA 52-58% 1-2mg 2-4mg 4-8mg 8mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-30 min 1-2 hrs 2-4 hrs 30-60 min 1-12 hrs
    Intravenous 1-5 min 5-10 min 30-60 min 2-4 hrs 1-12 hrs
    Insufflated 4-5 min 10-20 min 30-90 min 1-2 hrs 1-2 hrs
    Rectal 15-30 min - 1-2 hrs 2-3 hrs 12 hrs

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
    Cross-tolerance
    Morphine Heroin Oxycodone Fentanyl Codeine Tramadol Kratom Methadone

    Effects TheDrug.Wiki TripSit

    Positive
    • Physical euphoria
    • Pain relief
    • Cough suppression
    • Analgesia
    Negative
    • Respiratory depression
    • Nausea
    • Skin flushing
    • Dry Mouth
    Neutral
    • Sedation
    • Difficulty urinating
    • Itchiness
    • Pupil constriction
    • Relaxant
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Dream potentiation
    • Euphoria
    • Mood lift
    • Cognitive Euphoria
    • Anxiety Suppression
    Negative
    • Constipation
    • Compulsive redosing
    • Dizziness
    Positive
    • Visual geometry
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Decreased Libido
    • Appetite Suppression
    • Spatial disorientation
    Neutral
    • Dulled perception
    • Internal hallucinations
    • Internal hallucination
    • Visual and auditory hallucinations

    Combinations TripSit

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