Summary
Oxycodone (also known under brand names including Roxicodone, OxyContin, Percocet, Oxecta, OxyIR, Endone, Oxynorm, and OxyNEO) is a semi-synthetic opioid synthesized from poppy-derived thebaine. It is a narcotic analgesic within the morphinan chemical class and is generally indicated for relief of moderate to severe pain. It was developed in 1916 in Germany as one of several new semi-synthetic opioids in an attempt to improve on the existing opioids.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 2.5-7.5mg | 7.5-15mg | 15-25mg | 25mg+ |
| Oral | 2.5-10mg | 10-25mg | 25-40mg | 40mg+ |
| Intravenous | 2.5-5mg | 7.5-10mg | 12.5-15mg | 15mg+ |
| Smoked | 1.5-8mg | 8-20mg | 20-35mg | 30mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Insufflated | 0-6 min | 18-42 min | 1.5-4 hrs | 0.8-2 hrs | 60-0 min | - |
| Oral | 18-42 min | 1-2 hrs | 4-6 hrs | 0-2 hrs | 60-0 min | 240-0 min |
| Intravenous | 0 min | - | 3-5 hrs | - | 60-0 min | - |
| Smoked | - | - | - | - | 60-0 min | - |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Cross-tolerance
Effects
Positive
- Pain relief
- Cough suppression
- Physical euphoria
Negative
- Respiratory depression
- Nausea
- Stomach cramps
- Sedation
- Difficulty urinating
- Itchiness
- Pupil constriction
Positive
- Euphoria
- Anxiety suppression
- Dream potentiation
- Cognitive euphoria
- Mood lift
- Cognitive Euphoria
- Anxiety Suppression
Negative
- Constipation
- Compulsive redosing
- Dizziness
Positive
- Visual geometry
Negative
- Decreased libido
- Appetite suppression
- Decreased Libido
- Appetite Suppression
- Spatial disorientation
- Internal hallucinations
- Dulled perception
- Internal hallucination
- Visual and auditory hallucinations