Oxycodone - Substance Search

Summary PsychonautWiki

Oxycodone (also known under brand names including Roxicodone, OxyContin, Percocet, Oxecta, OxyIR, Endone, Oxynorm, and OxyNEO) is a semi-synthetic opioid synthesized from poppy-derived thebaine. It is a narcotic analgesic within the morphinan chemical class and is generally indicated for relief of moderate to severe pain. It was developed in 1916 in Germany as one of several new semi-synthetic opioids in an attempt to improve on the existing opioids.

Dose Information TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Insufflated	2.5-7.5mg	7.5-15mg	15-25mg	25mg+
Oral	2.5-10mg	10-25mg	25-40mg	40mg+
Intravenous	2.5-5mg	7.5-10mg	12.5-15mg	15mg+
Smoked	1.5-8mg	8-20mg	20-35mg	30mg+

Light Common Strong Heavy

Onset, Duration & After-effects TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Insufflated	0-6 min	18-42 min	1.5-4 hrs	0.8-2 hrs	1-24 hours	-
Oral	18-42 min	1-2 hrs	4-6 hrs	0-2 hrs	1-24 hours	5.3-10.7 hrs

Opioid MME Calculator

⚠ Citation & Disclaimer: Conversion factors sourced from the NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025), the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain, and the MDCalc MME Calculator. These are approximate equianalgesic ratios for educational reference only. Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration. This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.

Convert from

mg

Convert to

6.7 mg Oxycodone

≈

— mg Morphine

⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.

Effect Profile

445 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 350 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 7.0

Strong+ 7/10

Strong euphoria and itching/nausea with moderate sedation and pain relief

Euphoria / Warmth ×3

10

physical euphoria euphoria cognitive euphoria mood lift

Analgesia ×2

6

pain relief

Sedation / Relaxation ×1

7

sedation dream potentiation

⚠ Itching / Nausea ×1

10

nausea constipation

Based on reports from:

Erowid Experience Reports PsychonautWiki Oxycodone The Drug Users Bible Oxycodone

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 5d Half tolerance 4d Baseline ~14d

Opioid tolerance to euphoria/analgesia builds within days of daily use and decays over 1–4 weeks of abstinence; tolerance to constipation and pupillary effects lags. Tolerance to respiratory depression may not keep pace with loss of subjective sedation—risk rises after breaks or when switching products. Values are approximate and synthesis‑based (clinical/anecdotal).

Cross-Tolerances

Morphine

80%

Hydrocodone

80%

Heroin (diacetylmorphine)

80%

Fentanyl

60%

Hydromorphone

80%

Effects Erowid Bluelight

Aggregated from 350 Erowid and 95 Bluelight experience reports

Positive Effects 50

Contentment 60.0% 86%

Euphoria 54.2% 92%

Empathy 39.4% 70%

Sedation 34.3% 88%

Anxiety Suppression 28.0% 79%

Stimulation 26.5% 81%

Drowsiness 26.0% 87%

Sociability Enhancement 24.0% 85%

Body High 22.5% 91%

Thought Deceleration 22.0% 80%

Music Enhancement 20.5% 85%

Numbness 18.0% 84%

Warmth 14.0% 90%

Tingling 14.0% 85%

Tactile Enhancement 14.0% 85%

Focus Enhancement 12.8% 82%

Peace 12.0% 84%

Bliss 12.0% 89%

Joy 12.0% 87%

Pressure 10.0% 84%

Adverse Effects 51

Nausea 34.2% 85%

Ataxia 14.0% 80%

Confusion 14.0% 70%

Dry Mouth 12.0% 83%

Vomiting 12.0% 92%

Auditory Effects 11.0% 82%

Headache 10.3% 70%

Body Load 10.0% 74%

Dizziness 10.0% 85%

Sweating 8.5% 83%

Irritability 8.0% 75%

Body Temperature Change 6.0% 78%

Fear 6.0% 85%

Amnesia 6.0% 82%

Muscle Tension 4.6% 70%

Increased Heart Rate 4.3% 70%

Blurred Vision 4.0% 82%

Dysphoria 4.0% 85%

Tremor 4.0% 80%

Emotional Blunting 4.0% 82%

Combinations TripSit

Pill Identifiers

48 known pill identifiers on record — view imprints, colors, shapes, and images

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Oxycodone's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

💊 Pill Identifier 📘 Experience Reports 📖 TripSit 📖 PsychonautWiki 📖 The Drug Users Bible