Summary
Morphine is a potent naturally-occurring opioid analgesic extracted from the opium poppy, used for moderate to severe pain management. Overdose can result in fatal respiratory depression, especially when combined with other CNS depressants. Long-acting formulations exist for extended pain relief. Morphine is metabolized primarily via glucuronidation to M3G and M6G, with M6G being a more potent active metabolite. Use extreme caution with compromised respiratory function or liver impairment.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA 35%-40% | 10-15mg | 15-20mg | 20-30mg | 30mg+ |
| Intravenous BA ~100% | 3.33-5mg | 5-7.5mg | 7.5-10mg | 10mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 10-30 min | 20-40 min | 2-3 hrs | 1-2 hrs | 6-12 hrs | 240-0 min |
| Intravenous | 0-1 min | 2-5 min | 1.5-2.5 hrs | 60-90 min | 6-12 hrs | - |
| Intramuscular | 10-30 min | 20-40 min | 1-2 hrs | 2-4 hrs | 6-12 hrs | - |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Cross-tolerance
Effects
Positive
- Physical euphoria
- Pain relief
- Cough suppression
- Muscle relaxation
- Analgesia
Negative
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Pupil constriction
- Difficulty urinating
- Relaxant
Positive
- Cognitive euphoria
- Anxiety suppression
- Euphoria
- Mood lift
- Cognitive Euphoria
- Dream potentiation
Negative
- Constipation
- Thought deceleration
- Compulsive redosing
- Dizziness
Positive
- Visual geometry
Negative
- Double vision
- Appetite suppression
- Decreased Libido
- Appetite Suppression
- Spatial disorientation
- Internal hallucination
- Internal hallucinations
- Dulled perception
- Visual and auditory hallucinations