Morphine
Aliases: M, Morpho, Monkey, Dreamer, Roxanol
Summary
Morphine is a potent naturally-occurring opioid analgesic extracted from the opium poppy, used for moderate to severe pain management. Overdose can result in fatal respiratory depression, especially when combined with other CNS depressants. Long-acting formulations exist for extended pain relief.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA 35%-40% | 10-15mg | 15-20mg | 20-30mg | 30mg+ |
| Intravenous BA ~100% | 3.33-5mg | 5-7.5mg | 7.5-10mg | 10mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 10-30 min | 20-40 min | 2-3 hrs | 1-2 hrs | 3.5-6.2 hrs |
| Intravenous | 0-1 min | 2-5 min | 1.5-2.5 hrs | 60-90 min | - |
| Intramuscular | 10-30 min | 20-40 min | 1-2 hrs | 2-4 hrs | - |
Opioid MME Calculator
| Substance | Equivalent Dose | MME Factor |
|---|
⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
147 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 137 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong pain relief and itching/nausea with moderate euphoria and sedation
“Preparing your shot in a warm environment may assist as well as things like wearing a warm hat (beanie etc) and jumpers, tracksuits.”
“The guide on here says use 10 to 20 mls of warm water.”
“– Morphine is a highly potent opiate analgesic psychoactive drug, is the principal active ingredient in Papaver somniferum (opium), is considered to be the prototypical opioid.”
“and i usually plug all of it except 30mgs, which i put up my nose*(even though the B/A isnt great), it just seems like having the powder in my nose satisfies the urgent need to get high and then a...”
“Withdrawals are like most other drugs of this class; nausea, tearing, yawning, chills, body aches, insomnia, loss of appetite, dysphoria and excessive sweating, etc lasting anywhere up to a week or...”
“What could be done to prevent a strong nausea/stomach cramping from taking a 30mg generic MS Contin as prescribed?”
User Experience
Tolerance
Tolerance Decay
Opioid tolerance builds rapidly to euphoric/sedative effects, more slowly to analgesia, and poorly to constipation. After cessation, appreciable tolerance decay typically takes several days, but returns to near‑baseline can require 1–2+ weeks depending on prior dose/duration; re‑initiation after a break must account for lost tolerance to avoid overdose. Opioid‑induced hyperalgesia (OIH) may coexist with tolerance and can present as worsening pain despite escalating doses.
Cross-Tolerances
Effects
Aggregated from 137 Erowid and 10 Bluelight experience reports