Bufotenin - Substance Search

Summary TheDrug.Wiki Erowid PsychonautWiki

Bufotenin is a naturally occurring tryptamine found in Anadenanthera (Yopo/Cebil) seeds and in the parotoid glands of certain Bufo and Incilius toads. The Colorado River toad (Incilius alvarius) contains primarily 5-MeO-DMT, not bufotenin, and 'toad-licking' is extremely dangerous due to cardiotoxic bufadienolides in the venom. Pure bufotenin freebase vaporizes at approximately 160°C; use low-temperature glass pipes or e-mesh devices to minimize harshness.

Perspectives

“Within a minute (from the start of the injection) I had a tight feeling in my chest and my face felt as if it had been jabbed by nettles and this lasted for about 6 minutes. I had fleeting nausea.”

— Alexander Shulgin, TiHKAL (with 1 mg, intravenously, over a three minute period)

Dose Information TheDrug.Wiki PsychonautWiki

ROA	Light	Common	Strong	Heavy
Smoked	5-20mg	20-40mg	40-60mg	60mg+
Insufflated	~50-100mg(seeds,pulverized)	-	-	-

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects
Smoked	0-1 min	0-1 min	1-5 min	5-10 min	10-60 min
Insufflated	2-10 min	5-15 min	20-40 min	30-60 min	30-90 min
Sublingual	5 min	10-20 min	35-40 min	30-60 min	30-90 min
Oral	30-60 min	30-60 min	1-2 hrs	1-2 hrs	2-6 hrs

Effect Profile

4 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 7.0

Strong+ 7/10

Strong body load, visuals, headspace, and auditory effects

Visual Intensity ×3

8

color enhancement drifting color shifting environmental orbism visual acuity enhancement

Headspace Depth ×3

8

conceptual thinking recursion emotion enhancement thought loops time distortion

Auditory Effects ×1

8

auditory distortion auditory distortions

⚠ Body Load / Somatic Effects ×1

10

vasoconstriction temperature regulation suppression nausea bodily pressures stomach discomfort

Based on reports from:

TiHKAL TiHKAL #19: 5-HO-DMT Erowid Experience Reports PsychonautWiki Bufotenin

Tolerance

Build-up develops rapidly after a single use

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 0h Half tolerance 0d Baseline ~1d

Rapid acute tolerance is typical of short-acting tryptamines; sensitivity partially returns within hours but cross-tolerance to other psychedelics can persist into the next day. Data quality primarily anecdotal.

Cross-Tolerances

Psilocin

40%

DMT

40%

LSD

30%

Other serotonergic psychedelics

30%

Effects Erowid

Aggregated from 4 Erowid experience reports

Positive Effects 2

Euphoria 100.0% 70%

Color Enhancement 75.0% 70%

Adverse Effects 0

Combinations TripSit

PiHKAL / TiHKAL Shulgin

TiHKAL #19: 5-HO-DMT

“Within a minute (from the start of the injection) I had a tight feeling in my chest and my face felt as if it had been jabbed by nettles and this lasted for about 6 minutes. I had fleeting nausea.”

— Alexander Shulgin, TiHKAL (with 1 mg, intravenously, over a three minute period)

Bufotenin's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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