In my now 5 years long period of drug use, I have tested and abused a LARGE variety of substances, ranging from psychedelics to opiates and all sorts of stimulants and niche drugs. But there is a class that stuck to me as the most profound in nature; dissociatives.
Deschloroketamine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Aliases: 2'-oxo-pcm, 2-oxo-pcm, dck, dxe, o-pcm, opcm
Summary
2'-Oxo-PCM (also known as deschloroketamine, O-PCM, DXE, and DCK) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic and hallucinogenic effects when administered.
Perspectives
“This stuff is great. It is a beautiful colorful adventure space like MXE, where I can to a degree create a world of my own design. I feel like with more trials and more focused meditation I can totally control this.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated BA ~50% | 10-15mg | 15-25mg | 25-40mg | 40mg+ |
| Oral BA ~40% | 10-20mg | 20-30mg | 30-50mg | 50mg+ |
| Smoked | 5-10mg | 10-20mg | 20-40mg | 40mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 6-12 min | 30-60 min | 1.5-2.5 hrs | 1-2 hrs | 3-6 hrs |
| Oral | 12-30 min | 30-60 min | 1.5-2.5 hrs | 1-2 hrs | 3-6 hrs |
| Smoked | - | - | - | - | 3-6 hrs |
Effect Profile
31 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 31 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
5.7
Strong
6/10
Strong dissociative depth, motor impairment, and mania with mild insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
spatial disorientation
+2 more
Mania / Compulsion
×1
8
disinhibition
stimulation
Insight / Novel Thought
×2
4
conceptual thinking
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
+1 more
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2β4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
2d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Anecdotal data suggest marked acute tolerance after a day or two of consecutive dosing, partial decay after several days, and nearβbaseline after 1β2 weeks; crossβtolerance is common across NMDAβantagonist dissociatives. Data quality is low and individualized.
Cross-Tolerances
Effects
Aggregated from 31 Erowid experience reports
Positive Effects 10
Stimulation
54.8%
70%
Music Enhancement
48.4%
70%
Color Enhancement
41.9%
70%
Euphoria
38.7%
70%
Empathy
35.5%
70%
Tactile Enhancement
25.8%
70%
Introspection
25.8%
70%
Focus Enhancement
16.1%
70%
Body High
12.9%
70%
Creativity Enhancement
12.9%
70%
Adverse Effects 8
Anxiety
38.7%
70%
Confusion
32.3%
70%
Motor Impairment
22.6%
70%
Nausea
22.6%
70%
Psychosis
12.9%
70%
Memory Suppression
9.7%
70%
Increased Heart Rate
9.7%
70%
Pupil Dilation
9.7%
70%
Combinations
Cross-Check Deschloroketamine with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 2 positive 5 neutral 1 cautionary visit
Deschloroketamine... Kind of disappointed. Not the real deal, sadly. After being unable to procure real ketamine for almost a decade, I decided to give this a shot.
Substance: Deschloroketamine (2Β-Oxo-PCM, DCK) Dose: 15mg, 30mg (Separate Occasions) R.O.A: Oral Person: 21/M, Height: 5Β9, Weight: 8 stone (112 lbs) Setting: My Bedroom/student house, London, Night time.
I took live notes during this one. They are incoherent. You can read them here: [url deleted / text pasted at end of report] I tried to incorporate them into the report as best I could but a good chunk of them I just don't remember and a lot of it just isn't even words.
PREVIOUS EXPERIENCE WITH DRUGS: Weed, alcohol, cocaine, amphetamines, methamphetamine, MDMA, Etizolam, Xanax, Modafinil. INTRO: For a long time I wanted to try and explore psychedelic drugs like LSD, something that would give me the ΒeyesΒ to see reality in a completely different manner, though I always felt scared of...
Context Deschlorketamine (nasal spray), Weed (inhaled) Date - 6.10.2021 Male, 19, 75kg Weed user on weekly basis Previous experiences - 1P-LSD, 1cP-LSD, 2C-C, 2-FDCK, 3-MMC, N-Ethyl-hexedrone, N-Ethyl-pentedrone, Psylocibin mushrooms, Deschlorketamine Had a few experiences with dissociatives, but only light doses, neve...
[Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects.
I have found Deschloroketamine to be one of the most versatile substances that I have worked with to date. And it works in a way that many other things do not, simply put, it works very well. As we are all aware, every person will undoubtedly have a different experience with this molecule.
Bluelight 2 threads 2 neutral visit
Age: 26 Weight: 130 lbs Dosage: 600 mg intranasal Setting: My house Preface: So of course I was super excited when I first saw this compound on the market. This was the first brominated arylcyclohexylamine to hit the market, and its activity would help us answer some questions about the role of different halogens on th...
510 MG OF DESCHLOROKETAMINE, A MILLIGRAM SCALE, A RECTAL SYRINGE... OK here is the report: It began with a miracle of modern service! I had ordered 500mg O-PCM with a vendor and had opted for a mail service.
Bluelight Reference Guide
Dissociatives The Big & Dandy Deschloroketamine Thread
2-(Methylamino)-2-phenylcyclohexanone Not totally novel, but there was no dedicated thread for it and it seems to be around again. Quote from adder in 2011: Well, 2-(methylamino)-2-phenylcyclohexanone actually existed (not sure if it's still an impurity in ketamine or not, or if it is/was sold as ketamine anywhere, I'm...
Read full thread on Bluelight β
Deschloroketamine's nerd page
Pharmacology, chemical data, effect profiles, and more
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