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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Deschloroketamine

    Aliases: 2'-oxo-pcm, 2-oxo-pcm, dck, dxe, o-pcm, opcm

    Dissociative

    Summary PsychonautWiki

    2'-Oxo-PCM (also known as deschloroketamine, O-PCM, DXE, and DCK) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic and hallucinogenic effects when administered.

    Perspectives

    “This stuff is great. It is a beautiful colorful adventure space like MXE, where I can to a degree create a world of my own design. I feel like with more trials and more focused meditation I can totally control this.”

    Dose Information PsychonautWiki TripSit

    ROA Light Common Strong Heavy
    Insufflated BA ~50% 10-15mg 15-25mg 25-40mg 40mg+
    Oral BA ~40% 10-20mg 20-30mg 30-50mg 50mg+
    Smoked 5-10mg 10-20mg 20-40mg 40mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects PsychonautWiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Insufflated 6-12 min 30-60 min 1.5-2.5 hrs 1-2 hrs 3-24 hrs 3-6 hrs
    Oral 12-30 min 30-60 min 1.5-2.5 hrs 1-2 hrs 3-24 hrs 3-6 hrs

    Effect Profile

    31 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 31 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 5.7
    Strong 6/10

    Strong dissociative depth, motor impairment, and mania with mild insight

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection cognitive disconnection visual disconnection spatial disorientation +2 more
    ⚠ Mania / Compulsion ×1
    8
    disinhibition stimulation
    Insight / Novel Thought ×2
    4
    conceptual thinking
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Based on reports from:
    Effect Index Encased in Stone Effect Index Lucid and Comfortable Sedation Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki Deschloroketamine
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Cross-Tolerances

    Ketamine
    70%
    O-PCE
    60%
    MXE
    60%
    DXM
    30%
    Other arylcyclohexylamines
    60%

    Effects Erowid

    Aggregated from 31 Erowid experience reports

    Positive Effects 10

    Stimulation 54.8% 70%
    Music Enhancement 48.4% 70%
    Color Enhancement 41.9% 70%
    Euphoria 38.7% 70%
    Empathy 35.5% 70%
    Tactile Enhancement 25.8% 70%
    Introspection 25.8% 70%
    Focus Enhancement 16.1% 70%
    Body High 12.9% 70%
    Creativity Enhancement 12.9% 70%

    Adverse Effects 8

    Anxiety 38.7% 70%
    Confusion 32.3% 70%
    Motor Impairment 22.6% 70%
    Nausea 22.6% 70%
    Psychosis 12.9% 70%
    Memory Suppression 9.7% 70%
    Increased Heart Rate 9.7% 70%
    Pupil Dilation 9.7% 70%

    Combinations TripSit

    Trip Reports Effect Index

    Encased in Stone nervewing Lucid and Comfortable Sedation froggie
    Deschloroketamine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 PsychonautWiki 📖 TripSit 📖 Bluelight