Over the past two weeks, my wife and I have been in Portugal for an annual music and arts festival called Waking Life. We were working as part of a group called Avozinha, or 'Little Grandmother' in Portuguese, helping to provide support for people who may have used drugs, were in need of psychedelic support, mental hea...
DMXE
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
Aliases: 3d-mxe, Warm-k, 3-me-2'-oxo-pce
Summary
DMXE emerged in October 2020 as an MXE replacement following MXE's global ban. Batches vary significantly in purity - tan/sandy powder often benefits from acetone recrystallization to reduce impurities and minimize hangover effects. Visual geometry tends toward blue-violet tessellated patterns.
Perspectives
“Oh what a lovely substance! There is so much this drug has to offer and I am excited to see it explored further. I will start with the negatives though, and I can only think of two- the short duration and the high dosage.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 5-20mg | 20-35mg | 35-60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 5-15 min | 30-90 min | 1-3 hrs | 1-2 hrs | 2-6 hrs |
| Oral | 19-40 min | 30-60 min | 30-90 min | 2-3 hrs | 3.32-6.17 hrs |
Effect Profile
14 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
5.7
Strong
6/10
Strong dissociative depth and motor impairment with moderate mania, low insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
visual disconnection
spatial disorientation
amnesia
Mania / Compulsion
×1
6
disinhibition
stimulation
euphoria
Insight / Novel Thought
×2
3
conceptual thinking
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
Based on reports from:
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The PsychonautWiki Journal logging app doesn't include every substance. To track DMXE there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "DMXE (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
DMXE
Unit
mg
Description
DMXE Source: SubstanceSearch (substancesearch.com) Insufflated dose (mg): threshold 5 ยท light 5-20 ยท common 20-35 ยท strong 35-60 ยท heavy 60+ Oral dose (mg): threshold 30-50 Insufflated duration: onset 5-15m ยท come-up 0.5-1.5h ยท peak 1-3h ยท offset 1-2h ยท total 2-6h ยท after-effects 1-2h Oral duration: onset 19-40m ยท come-up 0.5-1h ยท peak 0.5-1.5h ยท offset 2-3h ยท total 3.32-6.17h ยท after-effects 1-2h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 27.5 mg (Insufflated).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2โ4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
14d
Baseline
~28d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Acute tolerance rises within a session and across days; many users report unpredictability and diminished effects with frequent use. Long washouts (โฅ4 weeks) are commonly used to restore baseline response. Estimates are anecdotal and inferred from MXE/ketamine patterns and community reports on DMXE.
Cross-Tolerances
Effects
Aggregated from 14 Erowid experience reports
Positive Effects 9
Music Enhancement
78.6%
70%
Stimulation
64.3%
70%
Euphoria
57.1%
70%
Empathy
57.1%
70%
Color Enhancement
50.0%
70%
Focus Enhancement
50.0%
70%
Tactile Enhancement
42.9%
70%
Body High
35.7%
70%
Introspection
28.6%
70%
Adverse Effects 7
Anxiety
35.7%
70%
Confusion
35.7%
70%
Muscle Tension
21.4%
70%
Sweating
21.4%
70%
Motor Impairment
21.4%
70%
Memory Suppression
21.4%
70%
Nausea
21.4%
70%
Combinations
Cross-Check DMXE with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 1 positive 5 neutral 2 cautionary visit
For the impatient seeking one answer: Is this like MXE? In some ways yes, but it is hardly a perfect imitation. It is in fact something delightful and exciting entirely of its own and certainly worthwhile to explore further.
This trip is being documented as I experience it. The writing style reflects my mental state. Prior: 6ft 140lb male. My tolerance is fairly baseline. I've used a dissociative on average once a month this year. I've used the "new" batch of MXE (renowned for its lacklusterness) twice and both times were underwhelming.
Boofing 50mg DMXE and Watching Madoka Magica Trip Report Introduction I decided to boof 50mg of DMXE, a novel dissociative RC that I ordered online, and watch Madoka Magica, a popular anime series, in the evening after a stressful day. I had experience with 2fdck before, but this was my first time trying DMXE.
120mg live report: ROA: oral Goal: An experience similar to a K-hole. Hoping for psychedelic effects, as my previous experiences only have had dissociative effects. Tolerance: Slight tolerance due to prior DMXE use, though Iยm very sensitive to substances. 20mg was quite intense for me, so keep that in mind.
Dosed 90mg of 2-FDCK approx. 14 hours ago, all effects faded and I had a good 7 hours of sleep in that time, but I would presume it had an effect on my dissociative tolerance.
Iยve been self-medicating for about 25 years to manage what I later discovered in my late 30s was undiagnosed ADHD. The most effective treatment for me has always been full-psychedelic doses of psilocybin mushrooms.
This is more of a vague retrospective than a coherent trip report due to the nature of the drug in question and my own stupidity. Perhaps you can learn something from my mistakes, or just gawk at the sheer idiocy of the indomitable human spirit.
Bluelight 1 thread 1 neutral visit
Age: 25 Weight: 130 lbs Dosage: 70 mg intranasal Setting: My house Preface: For the impatient seeking one answer: Is this like MXE? In some ways yes, but it is hardly a perfect imitation. It is in fact something delightful and exciting entirely of its own and certainly worthwhile to explore further.
Bluelight Reference Guide
Dissociatives The Big & Dandy DMXE (3-me-2โฒ-oxo-PCE, deoxymethoxetamine) Thread
so the reptilian people have announced the release of DMXE, supposedly the best MXE replacement to date. im not big on dissos, but I would try MXE and this if its similar....please someone experienced on dissos chime in!!!
Read full thread on Bluelight โ
DMXE's nerd page
Pharmacology, chemical data, effect profiles, and more
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