Mazindol
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Sanorex, Mazanor, Teronac, Terenac, Dimagrir
Summary
Mazindol is a tricyclic anorexigenic agent approved for short-term obesity treatment and off-label narcolepsy management. Unlike amphetamines, it produces primarily dysphoric rather than euphoric effects, reducing abuse potential. Its dual mechanism targeting both monoamine reuptake and orexin-2 receptors makes it unique among stimulants.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1mg | 1-2mg | 2-3mg | 3mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 30-60 min | 2-4 hrs | 4-8 hrs | 8-12 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and anxiety/jitters with mild focus, low stimulation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance appears to build over 1–2 weeks of daily use and decays over 1–2 weeks of abstinence, consistent with other therapeutic stimulants; data quality is limited and largely extrapolated from clinical practice and user reports rather than controlled trials.
Cross-Tolerances
Effects
- Increased alertness
- Physical Euphoria
- Muscle relaxation
- Physical euphoria
- Restlessness
- Insomnia
- Dry mouth
- Increased heart rate
- Motor impairment
- Sedation
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Cognitive euphoria
- Anxiety
- Dysphoria
- Dizziness
- Drowsiness
- Motor control loss
- Confusion
- Appetite suppression
- Light sensitivity
- Disinhibition
- Acuity suppression
- Decreased Libido
- Acuity Suppression
- Visual acuity suppression
- Dulled perception
- Internal Hallucination
- Perception of bodily heaviness
Helpful Links
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