Mazindol
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Sanorex, Mazanor, Teronac, Terenac, Dimagrir
Summary
Mazindol is a tricyclic anorexigenic agent approved for short-term obesity treatment and off-label narcolepsy management. Unlike amphetamines, it produces primarily dysphoric rather than euphoric effects, reducing abuse potential. Its dual mechanism targeting both monoamine reuptake and orexin-2 receptors makes it unique among stimulants.
Dose Information
Dose basis. Dose ranges reflect historical prescription use; recreational use is not medically supported. Prefer morning dosing to reduce insomnia. Taking 1 hour before meals is typical; taking with food may lessen GI upset per product information and may modestly delay onset. Avoid frequent redosing due to long half-life and cumulative sympathomimetic load. Sources include regulatory product data aggregated by DrugBank; user reports are sparse. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1mg | 1-2mg | 2-3mg | 3mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 30-90 min | 2-4 hrs | 4-8 hrs | 7-14.5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria, mild focus, low stimulation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Mazindol there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Mazindol Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.5 · light 0.5-1 · common 1-2 · strong 2-3 · heavy 3+ Oral duration: onset 0.5-1h · come-up 0.5-1.5h · peak 2-4h · offset 4-8h · total 7-14.5h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance appears to build over 1–2 weeks of daily use and decays over 1–2 weeks of abstinence, consistent with other therapeutic stimulants; data quality is limited and largely extrapolated from clinical practice and user reports rather than controlled trials.
Cross-Tolerances
Effects
- Increased alertness
- Physical Euphoria
- Muscle relaxation
- Restlessness
- Insomnia
- Dry mouth
- Increased heart rate
- Motor impairment
- Sedation
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Cognitive euphoria
- Anxiety
- Dysphoria
- Dizziness
- Drowsiness
- Motor control loss
- Confusion
- Appetite suppression
- Light sensitivity
- Disinhibition
- Acuity suppression
- Decreased Libido
- Visual acuity suppression
- Dulled perception
- Internal Hallucination
- Perception of bodily heaviness
Helpful Links
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