Do Not Try and Hole With Memantine 21 years of drug expierience. It all started with Dextromethorphan and then Methoxetamine, I fell in love with dissociatives. Since MXE is no longer around and I no longer get any good results from DXM, when I heard of high doses of memantine being similar to MXE or mushroomesque even...
Memantine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 6 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 6 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Aliases: Dmaa, Ebixa, Axura, D-145, Memaxa
Summary
Memantine is a dissociative substance of the adamantane class that produces long-lived dissociative effects when administered. It is a derivative of amantadine and is pharmacologically related to compounds like PCP, ketamine, and DXM, although its recreational use is comparatively rare. Memantine was first synthesized by Eli Lilly and Company in 1968 as a potential agent to treat diabetes.
Perspectives
“This drug is certainly fascinating. Not entirely enjoyable or fun, rather it just felt fundamentally and deeply neutral. Its essence was elusive and mysterious, it felt as though it was a drug that existed at the fringes of consciousness that simply was not meant to be understood.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-70mg | 70-110mg | 110-170mg | 170mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30 min | 2-3 hrs | 3-12 hrs | 5-24 hrs | 48-72 hrs |
Effect Profile
40 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 30 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.4
Strong
6/10
Strong dissociative depth, motor impairment, and mania with moderate insight
Dissociative Depth
×3
10
depersonalization
derealization
cognitive disconnection
visual disconnection
perception of bodily lightness
amnesia
+1 more
Mania / Compulsion
×1
8
mania
stimulation
Insight / Novel Thought
×2
6
conceptual thinking
introspection
creativity enhancement
Motor / Sensory Impairment
×1
9
motor control loss
visual disconnection
Stimulant
8.1
Intense
8/10
Strong stimulation and euphoria with moderate anxiety/jitters and focus
Stimulation / Energy
×3
10
stimulation
stamina enhancement
Euphoria / Mood Lift
×2
10
physical euphoria
cognitive euphoria
Focus / Productivity
×2
6
Anxiety / Jitters
×1
7
vasoconstriction
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2β4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
14d
Half tolerance
14d
Baseline
~28d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Anecdotal reports suggest tolerance builds with frequent or daily use and decays over weeks of abstinence; cross-tolerance among NMDA antagonists is commonly reported by users but lacks controlled human data. Given memantineβs long half-life, apparent tolerance may reflect persistent baseline plasma levels rather than receptor-level adaptations. Data quality: anecdotal.
Cross-Tolerances
Effects
Aggregated from 30 Erowid and 10 Bluelight experience reports
Positive Effects 37
Stimulation
57.5%
83%
Euphoria
47.5%
95%
Color Enhancement
45.0%
82%
Visual Distortions
42.5%
80%
Thought Acceleration
40.0%
81%
Focus Enhancement
40.0%
80%
Closed-Eye Visuals
37.5%
86%
Music Enhancement
32.5%
92%
Empathy
30.0%
70%
Tactile Enhancement
23.3%
70%
Introspection
22.5%
82%
Mood Elevation
20.0%
85%
Mystical Quality
20.0%
90%
Awe
20.0%
82%
Contentment
20.0%
80%
Open-Eye Visuals
17.5%
88%
Body High
12.5%
80%
Auditory Effects
12.5%
85%
Joy
10.0%
85%
Patterning
10.0%
95%
Adverse Effects 21
Confusion
40.0%
82%
Anxiety
32.5%
80%
Dizziness
30.0%
82%
Motor Impairment
30.0%
82%
Nausea
22.5%
75%
Body Temperature Change
20.0%
88%
Thought Disorganization
20.0%
75%
Insomnia
20.0%
78%
Headache
16.7%
70%
Memory Suppression
15.0%
85%
Social Anxiety
10.0%
80%
Paranoia
10.0%
75%
Urinary Retention
10.0%
90%
Pain Enhancement
10.0%
80%
Sadness
10.0%
80%
Loneliness
10.0%
80%
Tinnitus
10.0%
95%
Diarrhea
10.0%
80%
Vomiting
10.0%
85%
Appetite Suppression
10.0%
70%
Combinations
Cross-Check Memantine with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 1 positive 5 neutral 2 cautionary visit
My Most Recent Experience I had only been home for a few hours after my week long New Year's trip, I had been staying with friends, drinking and celebrating the beginning of 2017, before I knew I wanted to make my first voyage into the Memanverse that night.
I had only been home for a few hours after my week long New Year's trip, I had been staying with friends, drinking and celebrating the beginning of 2017, before I knew I wanted to make my first voyage into the Memanverse that night.
I am a relatively experienced DXM tripper, and was really bored, and I remembered that there was alot of samples of Namenda in the cupboard so I looked it up online and it sounded like it would be fun.
Disassociation with namenda Today is 11-10-2014. I am a 150 Lb male in good health, not taking any medications or supplements. I recently came acrost some 5 mg Namenda (Mamantine) pills. After some research showing that they were indeed psychoactive I decided to eat them and see what happens.
I wanted to contribute my experience with memantine/Namenda not as a recreational drug but as a nootropic and antidepressant. Obviously, for recreational/psychedelic purposes, memantine is not going to be anyoneΒs first choice, and I donΒt think this is a productive use of the compound.
Addendum: 15-month follow-up This disaster of a trip is largely my own fault. I did not heed any advice I read online, went into it under the worst possible conditions, and took a higher starting dose than recommended.
Citation: Lazyvegan. 'A Few Words of Caution'. The Entheogen Review . Winter Solstice 2003;12(4):132-4. In the interest of harm reduction, I feel compelled to write this report. I have determined that memantine is indeed a psychoactive substance.
Bluelight 7 threads 6 neutral 1 cautionary visit
Age: 21 Weight: 120 lbs Dosage: 150 mg oral Setting: My apartment T0:00-Fifteen 10 mg memantine pills ingested. A quick shower was taken. T0:30-First notes arise, a very slight feeling of dissociation and dizziness melding with a sense of joviality and euphoria.
Age: 26, Weight: 140lbs Dose: 150mg oral + 75mg oral redose at around T-09:15 My intentions with this experience are: to explore this compound further (in ascending dosages), to help me gain some insight into some current predicaments in my life, and also to take a nice mental vacation.
Excerpts from my log (will explain and continue further) T+0 Began from a very moody morning. Did 2.5mg Lorazepam, had a good meal at McDonalds, and T+20' later did 10mg Memantine with water. T+40' Did 20mg more Memantine with Coke, began to feel ... more aggressive? T+60' Did 20mg more Memantine with Coke.
A much overdue update on my experiment! Background: I'm a veteran dissociative user, having used NMDA antagonists fairly consistently for about 9 years now. Started with DXM then ketamine, then 4-MeO-PCP then MXE and dabbled with 3-MeO-PCP and 3-HO-PCP.
Stomach: almost empty. Have some Alprazolam and Clonidine in case I feel bad or too excited. T - 1.00: I take 75mg Lyrica T - 0.30: I take 100mg Modafinil T - 0.00: I take 30mg Memantine with a Red Bull. Smoked 2 cigarettes.
Greetings to all. I take memantine daily - 20 to 60 mg at the moment. Lately I've been trying not to exceed 40mg (20mg in the morning and afternoon) orally for many reasons.
MEMANTINE - First Time- A few words of caution...! Well this is the final version of this report includuding additional commentaries from my original posting in the 'Psychedelics' forum a few months back, so I figured this finished version deserved a place in 'this' forum for those you who may one day be searching for...
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