Memantine
Aliases: Dmaa, Ebixa, Axura, D-145, Memaxa
Categories
Summary
Memantine is FDA-approved for moderate-to-severe Alzheimer's disease at therapeutic doses of 5-20 mg daily. Recreational use is rare due to extremely long duration (18-36+ hours with residual effects up to 72 hours) and slow onset. The 60-80 hour half-life causes multi-day accumulation; doses should be spaced by at least 72 hours to prevent dangerous buildup. High doses can cause prolonged dissociation, cognitive impairment, and mania lasting days. More clear-headed but less euphoric than ketamine or MXE.
Perspectives
“This drug is certainly fascinating. Not entirely enjoyable or fun, rather it just felt fundamentally and deeply neutral. Its essence was elusive and mysterious, it felt as though it was a drug that existed at the fringes of consciousness that simply was not meant to be understood.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-70mg | 70-110mg | 110-170mg | 170mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30 min | 2-3 hrs | 3-12 hrs | 5-24 hrs | 8-72 hrs | 2880-0 min |
Tolerance
Effects
- Stimulation
- Physical euphoria
- Stamina enhancement
- Creativity enhancement
- Stamina Enhancement
- Muscle Relaxation
- Nausea
- Headache
- Vasoconstriction
- Increased Blood Pressure
- Cognitive euphoria
- Introspection
- Conceptual thinking
- Anxiety suppression
- Depersonalization
- Derealization
- Motor control loss
- Amnesia
- Memory suppression
- Cognitive disconnection
- Mania
- Dizziness
- Constipation
- Dissociation
- Time distortion
- Perception of bodily lightness
- Bodily control enhancement
- Visual acuity enhancement
- Increased music appreciation
- After images
- Drifting
- Environmental cubism
- Environmental orbism
- Scenery slicing
- Internal hallucination
- Visual disconnection