Oxazepam - Substance Search

Summary TheDrug.Wiki TripSit

Oxazepam is an intermediate-acting benzodiazepine with slow onset used for anxiety, alcohol withdrawal, and insomnia. It is the active metabolite of diazepam, prazepam, and temazepam. Oxazepam has a slower onset than most benzodiazepines and is considered less sedating than alprazolam or lorazepam at therapeutic doses.

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	5-10mg	10-30mg	30-45mg	45mg+

Light Common Strong Heavy

Benzo Equivalence Calculator

Convert from

mg

Convert to

20.0 mg Oxazepam

=

— mg Diazepam

⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	0.5-2 hrs	30-60 min	2-4 hrs	4-8 hrs	12-12 hrs	7-15 hrs

Effect Profile

5 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Benzodiazepine 7.3

Strong+ 7/10

Strong anxiolysis and cognitive impairment with moderate sedation and euphoria

Anxiolysis ×3

10

anxiety suppression anxiolytic muscle relaxation muscle relaxant

Sedation / Relaxation ×2

7

sedation drowsiness muscle relaxation

⚠ Motor / Cognitive Impairment ×1

9

motor control loss cognitive impairment memory suppression double vision

Euphoria / Mood Lift ×1

6

physical euphoria disinhibition

Based on reports from:

Erowid Experience Reports PsychonautWiki Oxazepam

Tolerance

Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance

Reset weeks to months depending on half-life and duration of use; taper recommended

Tolerance Decay

Full tolerance 14d Half tolerance 7d Baseline ~28d

Dependence and tolerance can emerge within weeks with daily or near‑daily use; cross‑tolerance extends across GABA-A positive allosteric modulators. Data are mixed and largely based on class-level evidence and clinical practice rather than oxazepam-specific prospective trials.