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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Pregabalin

    Aliases: Lyrica, Nervalin, Pregablin

    Categories

    Depressant Opioid
    Pregabalin structure

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Pregabalin has greater than 90% oral bioavailability and is eliminated renally as unchanged drug with a mean half-life of 6.3 hours in normal renal function. Dose reductions required in chronic kidney disease. While overdose alone is rarely fatal, severe respiratory depression and coma occur when combined with opioids or other CNS depressants. UK MHRA and US FDA warnings highlight these risks. Recreational users report warm euphoria, sociability, and alcohol-like motor incoordination at 300-600 mg, with tolerance developing rapidly.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 50-225mg 225-600mg 600-900mg 900mg+
    Rectal 40-200mg 200-450mg 450-600mg 600mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-60 min 1-2 hrs 4-6 hrs 4-8 hrs 4-10 hrs 240-0 min
    Insufflated 15-30 min 0.5-2 hrs 2-3 hrs 3-5 hrs 6-12 hrs 360-0 min
    Rectal 12-30 min 0.5-2 hrs 2-3 hrs 3-5 hrs 6-12 hrs 360-0 min

    Tolerance

    Build-up develops over 1–2 weeks of daily use
    Reset 1–2 weeks of abstinence
    Cross-tolerance
    Gabapentin Phenibut

    Effects TheDrug.Wiki TripSit

    Positive
    • Physical euphoria
    • Muscle relaxation
    • Pain relief
    • Anxiolytic
    • Muscle Relaxant
    • Seizure suppression
    Negative
    • Muscle spasms
    • Respiratory depression
    Neutral
    • Sedation
    • Spontaneous bodily sensations
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Empathy, affection, and sociability enhancement
    • Motivation enhancement
    • Empathy, love, and sociability enhancement
    Negative
    • Motor control loss
    • Dizziness
    • Analysis suppression
    • Thought deceleration
    • Amnesia
    • Information processing suppression
    Positive
    • Increased music appreciation
    • Perception of bodily lightness
    • Tactile enhancement
    • Tracers
    • Acuity enhancement
    • Auditory enhancement
    • Colour enhancement
    Negative
    • Disinhibition
    • Double vision
    • Visual acuity suppression
    Neutral
    • After images
    • Internal hallucinations

    Combinations TripSit

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