Summary
Very little modern clinical data exist. Early 1950s human studies suggested ฮฒ-meprodine is roughly equipotent to, or slightly less potent than, morphine by weight, while its stereoisomer ฮฑ-meprodine is several-fold stronger. Because ฮฒ-meprodine is Schedule I in the United States and internationally controlled, it is almost never encountered outside of research or illicit synthesis. All meperidine-type opioids can precipitate serotonin syndrome when combined with MAOIs or high-dose serotonergic drugs. Fatal respiratory depression has been reported at therapeutic doses in opioid-naive subjects.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 2-3 hrs | 1-3 hrs |
| Intramuscular | 1-5 min | 30-60 min | 2-3 hrs | 1-3 hrs |
| Intravenous | 1-5 min | 30-60 min | 2-3 hrs | 1-3 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Effects
Positive
- Physical euphoria
- Pain relief
- Cough suppression
- Stimulation
Negative
- Respiratory depression
- Nausea
- Abnormal heartbeat
- Sedation
- Pupil constriction
- Itchiness
Positive
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Euphoria
- Focus enhancement
- Motivation enhancement
- Memory enhancement
Negative
- Constipation
- Time distortion
- Thought acceleration
Positive
- Increased libido
Negative
- Appetite suppression
- Dehydration
- Light sensitivity
- Acuity Suppression
- Decreased Libido
- Appetite Suppression
- Orgasm Suppression
- Disinhibition
- Dulled perception